Can cannabis help with glaucoma?
Glaucoma is a common eye condition that often causes optical nerve damage and when left untreated can lead to blindness. In the US, about three million Americans live with glaucoma; globally, the figure is close to 60 million. Glaucoma is recognized as one of the leading causes of irreversible blindness.
Since 1980, surgical procedures and treatments have improved significantly, cutting the risk of developing blindness nearly in half. Nonetheless, while treatment has improved, the number of effective topical drugs remains limited.
Almost universally recognized in medical marijuana states as a qualifying condition, increasing numbers of people have turned to cannabis to help their condition. But is marijuana actually good for glaucoma?
Given the improvement of existing glaucoma treatments, do the benefits of medical cannabis outweigh the potential side effects or risks? Likewise, given the vital role the body’s endocannabinoid system (ECS) plays in disease, what promise does the future hold for developing cannabinoid-derived medications to help with glaucoma?
What causes glaucoma?
Evidence increasingly suggests glaucoma—now widely considered to be a neurodegenerative condition—has a connection to other neurodegenerative diseases like Alzheimer’s disease. Glaucoma appears to be a significant predictor of Alzheimer’s. A precise cause of glaucoma, however, remains a mystery and continues to elude the scientific community.
Current glaucoma treatment options
Because intraocular pressure (IOP) influences the onset and progression of glaucoma, ophthalmologists prescribe treatments that target intraocular pressure. In fact, the only way to prevent vision loss or eventual blindness is to lower IOP levels.
Depending on the severity and progression, ophthalmologists may treat glaucoma with medications such as prescription eye drops, or, if necessary, surgery.
Can marijuana be used for glaucoma treatment?
Going back to the 1970s, studies have shown that cannabinoids can alleviate glaucoma-related symptoms because they lower intraocular pressure (IOP) and have neuroprotective actions. For example, this 1971 study found that ingestion of cannabis lowers IOP by 25-30%.
Despite the findings from early research, few ophthalmologists support the use of medical marijuana for patients with early to mid-stage glaucoma. The main issue ophthalmologists have is that potential adverse effects —particularly when smoking weed—might outweigh short-term benefits. For example, smoking can lead to unstable intraocular pressure, thereby increasing the risk of permanent vision loss.
Further, because its therapeutic effects on glaucoma are short-term, patients would have to consume cannabis frequently—once every three to four hours.
Doctors claim that because glaucoma needs to be treated 24 hours a day, patients would need to consume cannabis six to eight times over the course of a day to achieve consistently lowered IOP levels. Such frequency is hard to maintain and could increase the risk of developing a cannabis use disorder.
However, when it comes to late-stage glaucoma, ophthalmologists are more inclined to embrace cannabis to help with the condition. In later stages of glaucoma, it’s less about directly targeting glaucoma and more about alleviating the accompanying symptoms.
According to ophthalmologist Andrew Bainnson, MD, “We’ve known for some time that medical marijuana is very effective for treating nausea and pain, but not so much for glaucoma. There are some patients with end-stage pain and nausea who may benefit [from medical marijuana], but not from the glaucoma point of view.”
Can cannabis-based treatments play a greater role in the future?
The body’s endocannabinoid system (ECS), is one of our most important physiological systems. Nearly every aspect of our health—including inflammation, immune response, neuroprotection, and pain modulation—are all dependent on the ECS. Given the vital role of the ECS, particularly in neuroprotection and inflammation, cannabinoid-based medications could be immensely useful in treating and preventing glaucoma.
Cannabinoid receptors are prominent in ocular tissues responsible for regulating intraocular pressure. Cannabinoid-derived medications could be developed to serve two roles: lower IOP and protect retinal cells.
Evidence suggests two cannabinoid agonists—WIN55212-2 and anandamide—and several cannabinoids, including CBD and CBG, may be good candidates to develop as therapeutic agents, particularly because even when administered topically (directly to the eye), they are well tolerated.
Challenges with treating glaucoma with cannabis
However, challenges persist: Oral preparations are not good because bioavailability is poor and absorption unpredictable. Inhalation isn’t ideal because effects don’t last long enough.
That leaves topical preparations. But cannabis eye drops—while superior to oral and inhalation administration—do a poor job penetrating intraocular tissues.
The future of medical marijuana and glaucoma
While cannabis, as it is administered today, may not be an ideal treatment for glaucoma, the development of cannabinoid-derived medications represent a promising future direction. And, whether or not cannabis is an ideal glaucoma treatment, there are some people who swear by it as a godsend for their condition, while others consume it as an adjunct to therapy, but not as their primary treatment.
If you or someone you know has successfully used cannabis to treat glaucoma, share your experience with us in the comments section.
This post was originally published on September 22, 2016. It was most recently updated on March 13, 2020.
Glaucoma is a serious eye condition affecting over 3 million Americans. Learn more about marijuana being used as a potential treatment option.
Glaucoma, Marijuana, & CBD Oil
As marijuana use becomes more accepted and increasingly legalized, glaucoma patients frequently ask if marijuana can really treat glaucoma. We need to explain some truths and dispel some myths.
Marijuana is legal for medical use in 30 US states and for recreational use in 9 US States. It’s legal across Canada for recreational use. Despite the relaxed attitude around marijuana, it is still classified by the federal Drug Enforcement Agency as a Schedule I controlled substance (the same category as heroin and LSD ).
Does Marijuana Lower Intraocular Pressure?
Marijuana’s ability to lower intraocular pressure (IOP) was discovered in the 1970s. Elevated IOP is the major risk factor for developing glaucoma and for the progression of glaucoma. Treatment is focused solely on reducing IOP. Many have wondered whether marijuana could be used as a therapy to lower IOP and prevent glaucoma from getting worse or causing blindness.
While marijuana does lower IOP, it has major drawbacks as a treatment for a chronic, long-term, disease like glaucoma:
- First, unlike glaucoma eyedrops (some of which are effective for up to 24 hours), smoking THC reduces eye pressure for only 3-4 hours. Marijuana would require 8-10 doses per day.
- This would cost more than typical glaucoma treatment
- The physical and mental side-effects of frequent marijuana use would reduce one’s productivity.
- Marijuana also impairs judgment and coordination, increases paranoia, elevates heart rate, and irritates the eyes.
Are There Long-Term Side Effects of Marijuana?
Marijuana can cause permanent lung damage when smoked, and possible permanent adverse effects on cognition and mental health. With regular use, tolerance to the eye pressure-lowering effects develops, meaning that increasing drug levels would be required to prevent progression of glaucoma. Moreover, lack of regulation and quality control makes efficacy and safety of marijuana unpredictable. Research efforts to develop THC eyedrops that can effectively lower eye pressure while minimizing side effects are being studied, but have not yet been successful.
What About CBD (cannabidiol) Oil?
New evidence has emerged showing that parts of the cannabis plant, specifically cannabidiol (CBD), the non-intoxicating, trendy component, may actually worsen glaucoma symptoms. Researchers at Indiana University published a study in the journal Investigative Ophthalmology & Visual Science that shows CBD increases pressure in the eye. This is problematic, they say, considering that CBD has become such a household name in American culture that many people, some of which may have or be at risk for glaucoma, are using it haphazardly as a natural, harmless medicine. But in reality, CBD could be destroying their overall eye health.
The Final Verdict
For these reasons, smoking marijuana or using CBD oil is not recommended as a medical treatment for glaucoma. If you use marijuana or CBD oil, let your ophthalmologist know since it may have an impact on your eye pressure readings. Also, it is very important to continue the glaucoma treatment recommended by your ophthalmologist. This treatment and regular monitoring can help you maintain your vision for the rest of your life.