CBD vs. THC: What’s the difference?
Cannabis consumers have long prized potency (a high THC content) as one of the main factors that makes a particular strain more desirable. Though traditional demand for THC has caused an oversaturation of high-potency products, many consumers are starting to prefer less intense products that are lower in THC and higher in the non-intoxicating compound called CBD (cannabidiol).
What’s the difference between CBD and THC?
THC and CBD are both cannabinoids derived from the cannabis plant, but they’re different in many ways that may influence your next dispensary purchase.
An easy way to think about it is that THC is defined by what cannabis makes you feel, while the effects of CBD can’t be felt. The important distinction is that, unlike THC, CBD will not intoxicate you. It also addresses one of the most common reasons people choose to use CBD—pain management.
CBD can also block some of the intoxicating effects of THC. By binding to cannabinoid receptors, it will keep THC from activating those receptors. This translates to a less intense psychoactive effect, which is why products with a mix of CBD and THC are great for first-time consumers.
This does not mean that CBD, by itself, cannot offer an effect. High doses of CBD often produce a profoundly relaxing experience. Like stepping out of a hot tub, your body may feel tingly and relaxed, and your brain may be clear.
CBD vs. THC: legality
With the passing of the Farm Bill in December 2018, industrial hemp became a legal agricultural commodity in all 50 states. While the DEA still considers CBD to be a Schedule I controlled substance, it clarified in a memo that trace amounts of CBD found in hemp stalks or seeds were legal.
However, the legality of hemp-derived CBD may vary from state to state, so it’s important to check your state’s laws before stocking up on hemp-derived CBD products.
Cannabis strains that have a high CBD:THC ratio are legal only in states with legal, regulated cannabis markets.
What are the medicinal effects of CBD?
The list of conditions CBD may help with is ever-expanding. More research is needed to better understand the efficacy and range of CBD’s benefits, but it’s popularly used to manage the following symptoms and conditions:
- Epilepsy and seizure disorders
- Pain and inflammation
- PTSD and anxiety
- Crohn’s disease
- Multiple sclerosis
- Opioid withdrawal
Though clinical and anecdotal evidence suggests CBD can help manage different conditions, CBD became most famous for treating a rare and debilitating form of pediatric epilepsy.
Dravet’s Syndrome is notoriously resistant to current treatment methods. People with the condition are plagued by seizures, often up to hundreds a day, and they usually worsen as people age and can be life-threatening. Currently, treatment methods include having a child wear an eyepatch, specialized diets, and brain surgery, but all have mixed success rates.
One of the earliest success stories involves a young girl named Charlotte who was given an ingestible oil derived from Charlotte’s Web , a CBD strain that was specifically developed to provide her with all the benefits of the drug without the high.
In less than two years, Charlotte went from a monthly seizure count of 1,200 to about three. Other success stories followed and more parents have begun to speak out, particularly parents desperate for access to this life-saving treatment.
CBD has no lethal dose or known serious side effects. The idea of using cannabis-derived compounds for pediatric conditions remains a touchy subject in a culture where cannabis has been stigmatized.
If you would like to know more about the benefits of CBD, check out our CBD Guide.
Although THC is best known for its mind-altering euphoria, it too has important medical benefits. There’s some overlap in what CBD and THC can treat, but THC is particularly effective in relieving nausea, appetite loss, insomnia, among other symptoms. Many patients find that a balance of CBD and THC offers the best symptom relief as the two work together synergistically.
What are some high-CBD strains I can try?
CBD is typically the second-most abundant cannabinoid in cannabis, but this isn’t always the case. A strain may deliver CBD and THC in the following ratios:
- High THC, low CBD (e.g.,10-30% THC, trace amounts of CBD)
- Balanced CBD/THC (e.g., 5-15% THC and 5-15% CBD)
- High CBD, low THC (e.g., 5-20% CBD, THC under 5%)
(The Cannabiz Agency/iStock)
High-CBD strains tend to deliver very clear-headed, functional effects without the euphoric high associated with high-THC strains. They’re typically preferred by consumers who are extremely sensitive to the side effects of THC (e.g., anxiety, paranoia, dizziness).
A high-CBD strain would also be a great choice for someone needing to medicate throughout the day to control pain, inflammation, anxiety, or other chronic conditions.
Balanced CBD/THC strains will be a little more euphoric than CBD-dominant strains, though they’re much less likely to induce anxiety, paranoia, and other negative side effects. Strains like these tend to be the most effective for pain relief, and they’re also well-suited for THC-sensitive consumers who’d like a mellow buzz.
CBD strains can be consumed just as you would THC strains. You can smoke or vaporize CBD-rich flower, eat a CBD-infused edible, swallow a CBD oil capsule, apply a CBD lotion, or use a CBD tincture sublingually. Hemp products also contain CBD, though it is a less efficient source and lacks the beneficial chemical diversity of cannabis-derived CBD products (more on that here).
Keep in mind that CBD levels may vary from crop to crop—even from plant to plant. We also recommend checking with dispensaries about the specifics of their strains’ CBD levels. It’s always a good idea to purchase only lab-tested products that clearly state the CBD/THC levels so you know what kind of experience to expect.
This post was originally published on July 3, 2018. It was most recently updated on April 1, 2020.
CBD and THC are both derived from cannabis plants, but they’re very different. Learn the difference between CBD and THC.
CBD vs. THC: What’s the Difference?
In this Article
- Chemical Structure
- How CBD and THC Affect the Body
- Medical Benefits
- Side Effects
- What’s Legal?
YouвЂ™re probably hearing a lot about cannabis and marijuana products as they become legal in more and more states. Two natural compounds are getting the most attention: CBD and THC.
Cannabis is a plant that makes a thick substance full of compounds called cannabinoids. There are more than 100 of these chemicals in cannabis. They cause drug-like reactions in your body.
CBD (cannabidiol) and THC (tetrahydrocannabinol) are the most common cannabinoids found in cannabis products.
THC and CBD are in both marijuana and hemp. Marijuana contains much more THC than hemp, while hemp has a lot of CBD.
CBD and THC have the same chemical formula — 21 carbon atoms, 30 hydrogen atoms, and two oxygen atoms. The difference lies in the way the atoms are arranged. That gives CBD and THC different chemical properties, and they affect your body differently.
Both CBD and THC work with receptors that release neurotransmitters in your brain. They can affect things like pain, mood, sleep, and memory.
How CBD and THC Affect the Body
THC is the main psychoactive compound in marijuana. It’s what makes people feel “high.”
We have two types of cannabinoid receptors in our bodies. THC binds with receptors — mostly in the brain — that control pain, mood, and other feelings. That’s why THC can make you feel euphoric and give you that so-called high.
CBD doesn’t cause that high. Instead, it’s thought to work with other elements in the body linked to feelings of well-being.
People take CBD products to help with everything from arthritis and Crohn’s disease to diabetes and multiple sclerosis. Some say it helps with anxiety, insomnia, and chronic pain. So far, there’s little evidence that CBD helps with any of these.
The FDA has approved one CBD-based drug. Epidiolex is a treatment for several severe forms of rare childhood epilepsy.
CBD is a hot topic for researchers. The National Institutes of Health clinical trials database shows more than 160 trials involving CBD that are either active or recruiting.
As part of medical marijuana, THC helps ease things like:
- Problems with concentration
Side effects from CBD can include:
- Upset stomach
- Low blood pressure
CBD can also change the way some medicines work. Talk with your doctor about it.
Laws are changing all the time on cannabis. Many states allow medical marijuana, containing THC, for several uses, but it is still illegal under federal law. Some states have made recreational marijuana with THC legal for personal use. But it’s also illegal under U.S. law.
As part of the Farm Bill in December 2018, Congress legalized hemp. But there are still rules about where and how you can sell products that contain CBD. You canвЂ™t sell some across state lines, for example. All CBD products are illegal if theyвЂ™re sold with the promise of medical benefits.
Check your state’s laws before buying products with CBD or THC.
National Cancer Institute: “Cannabis and Cannabinoids (PDQ) — Patient Version.”
Dialogues in Clinical Neuroscience: “Cannabis, cannabinoids, and health.”
Echo Connection: “4 Differences Between CBD and THC,” “What Are the Differences Between CBD and THC?”
American Council on Science and Health: “CBD And THC – The Only Difference Is One Chemical Bond.”
Harvard Health Publishing: “Answers to the top questions about cannabis extract,” “Medical marijuana.”
FDA: “FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy.”
U.S. National Library of Medicine ClinicalTrials.gov: “CBD.”
UW Health: вЂњDo You Vomit When You Smoke Pot? HereвЂ™s Why.вЂќ
Alcohol and Drug Foundation: “Medical cannabis.”
National Center for Complementary and Integrative Health: “Marijuana and Cannabinoids.”
THC and CBD both come from cannabis, but they have different effects on the body and mind, and they aren’t always legal. Learn more.