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how to take cbd oil sublingually

How to Take CBD Oil: Ingestion, Sublingual, Topical and Inhalation Options

With more research discovering new potential wellness and therapeutic applications for cannabidiol ( CBD ), the demand and availability of CBD products continues to increase. The greater variety of products gives patients more choices to find a CBD option and method of consumption that aligns with their health and lifestyle needs.

In general, there are four primary methods for taking CBD oil to choose from:

  • Ingestion
  • Sublingual
  • Topical
  • Inhalation

Here we explore each of those four methods and discuss the advantages of each so that you can select a product that’s best for you or your family member.

Ingestion Options

Perhaps the most common way to take CBD oil is to ingest it orally. When you ingest CBD oil, it passes through the digestive system and is metabolized by the liver, eventually sending its active compounds to your bloodstream. This form of administration is exactly how vitamins and other daily supplements are most typically taken.

Common ingestible CBD oil products include capsules , edibles, and beverages. Capsules can be easily swished down with a mouthful of water and are among the most efficient ways to take CBD. CBD oil can be infused into a wide variety of edibles and beverages, including coffee.

Sublingual Options

When CBD oil is administered sublingually, it’s held under the tongue for up to 90 seconds so that the mucus membranes in the mouth can absorb the oil’s active ingredients. The benefit of consuming CBD oil sublingually is that the absorption process bypasses the digestive system and liver metabolization, allowing the compounds to reach your bloodstream and interact with the endocannabinoid system more quickly. For those looking for quick effects, a sublingual CBD oil product is ideal.

Pure CBD oil, as well as tinctures and concentrates, are CBD products that are designed for the sublingual method of application. They can easily be held in the mouth to give the active ingredients time to be absorbed by the capillaries in the mouth before being swallowed.

Topical Options

Some CBD oil products are designed to be applied directly onto the skin. The active ingredients in these topical CBD products are absorbed through the skin so that they can interact with cells that are nearby the surface without ever entering the bloodstream. Topical CBD oil products are ideal for those looking for isolated pain relief or to address skin conditions because they can be applied directly to where they are needed most.

The CBD oil topical products currently on the market primarily include lotions and salves. These products are more applicable for potentially addressing pain or serious skin issues . For daily skin health care, some companies also produce a collection of CBD oil bath and body care products, such as body wash, shampoo, conditioner, and moisturizing lotions.

Inhalation Options

Finally, CBD can also be inhaled by vaporizing. A vaporizer heats CBD oil just enough to release its active compounds, avoiding the harmful byproducts that are created with combustion. During vaporization, CBD enters your lungs and diffuses directly into your bloodstream. Because it doesn’t have to make its way through the digestive system or liver, the CBD enters your circulation faster. Also, less CBD is lost during vaporizing compared to the ingestion method. Vaporizing CBD is typically a consumption option recommended for adults.

CBD oil products designed for vaporization include CBD e-liquid, which contains CBD oil infused with vegetable glycerin (VG), or high-CBD concentrate. Vaporizers range in size from tabletop, plug-in powered units to small, battery-powered portable pens.

Here we explore each of the four common methods for consuming CBD and discuss the advantages of each so you can find the product that's right for you.

How to Take CBD Oil Sublingually

Green Roads CBD oil

For recreational users, smoking and vaping are the preferred methods of consuming cannabis or CBD products. These methods allow cannabinoids to rush directly to the lungs. Smoking and vaping are very efficient methods and can increase bioavailability to 50% or above. Bioavailability determines the percentage of drugs or substances that becomes available to the target tissue after administration. This means that up to 50% of the cannabis content that you inhale when you smoke or vape is available for your body. In contrast, CBD edibles fall between 4-20% bioavailability rate.

However, smoking, and vaping are not everybody’s cup of tea. Some just don’t like the idea of smoking or vaping in general. There are also those who find it inconvenient since it limits their use to their homes. Although vaping, and smoking equipment are portable, some areas prohibit smoking and vaping in public places; both indoors and outdoors. In addition, there are also those with existing lung conditions who cannot smoke or vape.

Sublingually taking CBD oil is a convenient alternative to smoking or vaping. The word sublingual means under the tongue. In this method, the user applies a few drops of CBD oil or cannabis tincture under the tongue. This method is different from directly swallowing the tincture or oil.

What are the advantages of taking CBD Oil sublingually?

Better Bioavailability. Most users who take CBD oil sublingually experience the health benefits of CBD oil within 20 minutes?. This makes it the perfect method for those who use CBD products for pain relief of chronic pain. Those who suffer from neuropathic pain caused by arthritis will also benefit from the fast relief brought about by sublingually taking CBD oil. Arthritis-related pain can flare up any moment and although you can relieve it by using other CBD products, CBD oil through sublingual delivery is still the best method to deliver immediate relief.

Why is the effect so fast? This might be due to the fact that you’re not digesting the oil. Sublingual products don’t go through the digestive tract. When you swallow a CBD edible or capsules, it goes through your digestive system and it needs to undergo digestion before you can feel its effect. In contrast, CBD oil or cannabis tincture taken sublingually gets absorbed directly into the bloodstream. The increased bioavailability can also be attributed to the fact that sublingual consumption of CBD Oil bypasses the first-pass effect in the liver which happens when you digest edibles.

It is a discreet method. You can sublingually take CBD oil in a very discreet manner. Unlike smoking or vaping CBD, you can do it in a quiet corner without anybody noticing. It doesn’t emit any smoke or smell that can draw attention to one’s self. This method also doesn’t require any prep work on the user’s end. The dropper bottles used in this method are very small and you can easily conceal them in your purse or even your pocket. Although a vaporizer and a bottle of vape oil is easy to conceal, a bottle of CBD oil is still smaller in comparison

How do I take CBD oil sublingually?

Taking CBD Oil sublingually is a pretty straightforward process. You just need to use the dropper that usually comes with the CBD Oil to take a few drops of CBD. Put a few drops of your preferred CBD Oil under your tongue. You need to hold the oil under your tongue for at least a minute or two. This will ensure that the oil gets absorbed through your sublingual tissues so it can enter your bloodstream. You can then swallow any excess oil left behind.

Some users who take CBD Oil sublingually take an extra step before swallowing the oil. You can also swish the remaining oil around your mouth. This will distribute the oil to your cheek tissues or even into your gums. This method of taking CBD Oil through the cheek tissues is called Buccal. If you’ve tried oil-pulling before then this is something similar.

Although this is not a requirement, it increases the contact between the oil and the capillaries in your mouth. This means you also increase the chances of getting as much CBD oil to your bloodstream as possible. If there is still oil left after swishing the oil around your mouth, then you can just swallow the rest.

What kind of carrier oil is best for taking CBD oil sublingually?

Pure CBD oil by itself is easily absorbed by the human body. However, its absorbency by the body gets improved when you use it with a carrier oil. Hemp oil products like THC and CBD from the cannabis plant are fat-soluble. This means that they increase their bioavailability when you infuse them in saturated fat.

Hemp Seed Oil. Despite its name, Hemp Seed Oil doesn’t contain cannabinoids. Hemp seed oil is a product derived by cold-pressing hemp seeds and not the hemp plant. What’s great about hemp seed oil is it contains a unique 3:1 essential fatty acids ratio. Hemp seed oil is also tastier. It has a slightly nutty flavor which makes it more tolerable if you intend to take CBD oil sublingually.

Olive Oil. Olive oil is a very popular cooking ingredient. People drizzle it over salads, use in making pasta, or as a dip for pieces of bread. It has a vegetable flavor and is ideal for those who like the taste of Olive Oil. Olive Oil also contains LCTs or long-chain triglycerides. LCT translates into higher bioavailability compared to medium-chain triglycerides (MCTs) which makes it more efficient as a carrier oil.

Coconut Oil. This MCT oil has long been acknowledged for its health benefits. This is the perfect carrier oil for those who have heart conditions because coconut oil has high lipid content. The saturated fat content of coconut oil won’t clog up your arteries.

How much CBD Oil should I use?

This is a question that many have asked. Unfortunately, there is no definite answer. The Food and Drug Administration (FDA) is the government arm responsible for providing a Recommended Daily Intake (RDI) but they haven’t released an official RDI for daily CBD servings. If you don’t know what RDI is, it is the daily levels of a nutrient that meets the requirements of 97-98 percent of individuals in the United States. You usually find RDI information on any supplement you purchase.

So, how do you formulate a dosage for CBD oil? Treat CBD as you would any new supplement that you might take. Start with small doses. This way, you completely avoid going over the level that might be too much for you. Remember that it can take up to an hour for you to feel the effects of CBD oil taken sublingually so you need to be patient and wait for the effects to your body. Once you’ve felt the effects and they are not enough for you, then you can gradually increase the dosage of the following intake.

If you know someone else who takes CBD oil sublingually, do not assume that the dosage that works for them will also work for you. The effects of CBD are different for each individual. In the absence of an FDA RDI, it will be best to determine on your own the right dosage based on what works for you.

Another thing to take note of is the potency of the CBD oil that you’re taking. Different oils have different potencies. If you decide to switch to another CBD oil then you need to take potency into consideration. If you switch to a more potent oil, lower the dosage you are taking and then gradually increase it. If you’re switching to a less potent oil, go with the same dosage you’re previously using and work your way up.

This is not an exact science yet. However, until the FDA comes up with an RDI for cannabis products, these are sensible and the safest you can get.

Genetics and CBD Dosages

Genetics also play a huge role in how a user decides on an appropriate dosage. Some users have mutations on their CNR1 gene. If you have an issue with your CNR1 gene, it can result in a poorly functioning endocannabinoid system. For example, THC can increase the activity of CB1 receptors. On the other hand, alcohol can increase its expression. This means that smoking cannabis and drinking alcohol can increase the effects of CBD because of their interaction with cannabinoid receptors.

Can I overdose on CBD oil if I take it sublingually?

As of this writing, authorities haven’t determined yet a lethal dose of CBD. Even doses of up to 1500 mg per day are safe for humans?. However, it is also important to consult with your physician before taking CBD oil sublingually, or through any other method for that matter. However, there are still some slight risks associated with the use of CBD in high doses or for extended periods. These include:

  • Mild Low Blood Pressure
  • Dry Mouth
  • Lightheadedness
  • Sluggishness

These side effects are possible on worst case scenarios. The use of CBD and other hemp products are still safe.

Sublingual CBD oil provides greater bioavailability than most other methods of consumption. Place a few drops underneath your tongue to feel the effects.

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cbd oil delaware

CBD in Delaware

November 7, 2019

CBD in Delaware

CBD oil has been on Delaware store shelves for a few years now, but where did it come from and what benefits does it have for consumers? NuLeaf Naturals wants to provide you with what you need to know about CBD oil including its legality and where to find CBD oil in Delaware.

Is CBD in Delaware Legal?

Under Delaware Senate Bill 17 (DE Medical Marijuana Act), Delaware residents must obtain a certification from their doctor and meet certain requirements to qualify for its medical marijuana program. Medical marijuana qualified patients can use any CBD products if they contain at least 15% CBD and less than 0.7% THC.

CBD oil Delaware

What is CBD?

Cannabidiol (CBD) is a cannabinoid that interacts without the body’s own endocannabinoid system. When CBD is ingested it binds to our body’s endocannabinoid system which is believed to cause several therapeutic benefits.

CBD Oil Terms You Should Know

Consumers can easily get confused by all the different terms and jargon when it comes to CBD. Use this glossary to differentiate between different types of CBD oil.

  • Full Spectrum: Full spectrum indicates the entire plant was used to manufacture the CBD. Legal full spectrum CBD oil contains a negligible amount of THC.
  • Broad Spectrum: Broad spectrum indicates the entire plant was used to manufacture the CBD, but that all THC has been removed. Broad spectrum CBD oil may lose other helpful compounds during production.
  • CBD Isolate: CBD in its purest form. CBD isolate has fallen out of favor to full spectrum CBD.
  • Hemp Oil: CBD oil derived from cannabis sativa (industrial hemp.) Hemp oil containing less than 0.3% THC is federally legal.
  • Cannabis Oil: CBD oil derived from non-hemp sources is better known as cannabis CBD oil or cannabis oil.

Where to Buy CBD in Delaware

Consumers can find NuLeaf Naturals full spectrum CBD oil at several reputable outlets. Use our store finder to find a NuLeaf Naturals retailer near you. We only partner with reputable suppliers who can give you on-the-spot help in answering your questions.

If you’d rather not leave your home and still have CBD questions or need help finding the right product call our experts at 720-372-4842. If you’re ready to order CBD oil now, navigate to our shop page for more information on our CBD products and how to buy now.

CBD oil is federally legally so long as it contains less than 0.3% THC, as mandated by the 2018 Farm Bill. It may not be legal at a state, county, or local level. Check your local laws and regulations before buying CBD oil.

This guide may not be up to date on the current legislation at the state or local level. We recommend you do your research to understand the legalities surrounding CBD oil where you live.

Can you buy CBD in Delaware? Is it legal to possess? Read the NuLeaf Naturals guide to CBD oil in The First State and get started with changing your life for the better.

Where to Buy CBD Oil in Delaware in 2020

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If you are trying to find the best deals on legal CBD oil in Delaware, this is the article for you.

Although Delaware historically doesn’t have the most friendly marijuana laws, there are still options for purchasing CBD oil online and in-store.

It’s usually easiest to shop for your products online rather than driving around town from store to store. You can find many of the same products online that you would find locally but the deals are often much better.

Shopping online also allows you to research the products quickly, which is important. The laws in Delaware regarding CBD oil can change significantly depending on how the CBD oil was made.

Table of Contents
  • Buy CBD Oil in Delaware:
  • Is CBD Legal in Delaware?
    • Medical Marijuana Law in Delaware
      • Eligible medical conditions for medical marijuana in Delaware:
  • Industrial-Hemp CBD Oil in Delaware
  • How to Buy CBD Oil in Delaware
    • Online Shops
    • Local Stores in Delaware
  • What Is CBD Oil? Why Is It So Popular?
  • Recommended CBD Retailers in Delaware
    • Wilmington
    • Dover
    • Newark
    • Middletown
  • Final Notes on Buying CBD Oil in Delaware

Buy CBD Oil in Delaware:

  • Royal CBD Oil— Best CBD Oil Overall
  • Gold Bee CBD Gummies— Best CBD Gummies
  • CBDistillery THC-Free Pure CBD Oil— Best CBD Isolate Oil
  • Industrial Hemp Farms— Best CBD Flower
  • Honest Paws CBD Oil For Dogs— Best CBD Oil For Dogs

Is CBD Legal in Delaware?

Yes, CBD oil is legal to purchase in Delaware, but you need to be aware of the law to avoid any trouble with the authorities.

Depending on whether or not your CBD oil contains THC, the legal circumstances can change.

Let’s examine the Delaware law regarding medical marijuana to see if you may be eligible to purchase CBD oil with a higher THC content.

Medical Marijuana Law in Delaware

In 2011, Delaware became the 16th state to legalize the use of medical marijuana.

Under the Delaware Medical Marijuana Act, residents of Delaware may apply for a medical marijuana license with the recommendation of a physician.

Additionally, you will need to pay a one-time $125 application fee and prove that you have an eligible condition.

Eligible medical conditions for medical marijuana in Delaware:
  1. Cancer
  2. HIV/AIDS
  3. Decompensated Cirrhosis
  4. Amyotrophic Lateral Sclerosis
  5. Crohn’s disease
  6. Autism
  7. Alzheimer’s disease
  8. Cachexia or Wasting Syndrome
  9. Severe/debilitating pain that has not responded to previously prescribed medication or surgical measures for more than three months or for which other treatment options produced serious side effects
  10. Severe nausea
  11. Seizures
  12. Severe and persistent muscle spasms
  13. Post-traumatic stress disorder (PTSD)
  14. Terminal illness

Strangely, this law doesn’t prevent an arrest for marijuana possession. It simply provides a legal defense if prosecuted.

If you are arrested for possession with a medical marijuana license, you may have a legal defense if you can satisfy the following conditions:

  1. You were in possession of no more than six ounces of marijuana and no plants.
  2. You possessed marijuana solely to treat or alleviate the patient’s severe or debilitating medical condition.
  3. Your physician has stated that you are likely to receive therapeutic benefit from marijuana to treat or alleviate your serious or debilitating medical condition.
  4. You didn’t possess marijuana on school grounds, on a school bus, in state-funded health care or treatment facility
  5. You weren’t smoking marijuana in a public place or in any form of transportation.

If you are under the age of 18, you may be able to apply for a medical marijuana license if you are suffering from one or more of the following conditions:

  1. Intractable epilepsy
  2. A chronic or debilitating disease or medical condition where they have failed treatment involving one or more of the following symptoms
    1. Cachexia or wasting syndrome
    2. Intractable nausea
    3. Severe, painful and persistent muscle spasms

Delaware recent passed “Rylie’s Law”, which permits caregivers to administer CBD oil to children with debilitating health conditions on school buses and school grounds.

Once you have obtained a medical marijuana license, you may be able to legally purchase CBD oil products through a local dispensary or easily find them online.

What if you don’t have a medical marijuana license?

Industrial-Hemp CBD Oil in Delaware

If you aren’t able to get a medical marijuana license, don’t worry. You can still legally purchase your favorite industrial-hemp products online and in-state.

Industrial hemp products are treated differently than those derived from flowering marijuana plants.

In 2014, the Federal government took hemp off of the Controlled Substances Act. This meant that farmers were legally allowed to grow hemp for paper, clothing, fuel, food, and research.

Luckily for those of you who are looking to buy CBD oil in Delaware, this small change means that industrial-hemp extracts are completely legal.

CBD oil derived from industrial hemp doesn’t typically contain enough THC (normally less than 0.3%) to get the user high. Using these products will get you all the benefits of CBD without the buzz.

You can find CBD oil in many different forms. It can be purchased as a tincture, cream, balm, wax, vape juice, and there are even products available for your pets.

Whether you decide to pick up your products online or in-store, there are a few things you should do to protect yourself from sketchy companies.

Read our guide below for finding quality CBD oils from a trustworthy supplier.

How to Buy CBD Oil in Delaware

As the laws and regulation around CBD evolve, it can be difficult to find quality products at a good price.

Some companies are advertising CBD oil as a miracle drug or selling items that contain significantly less CBD than they should.

You have come to the right place for finding quality CBD oil in Delaware. Follow these simple steps to protect yourself against sketchy companies.

  1. Always ensure that the CBD oils you purchase are double-checked by a third-party lab. These labs can test for unwanted chemicals or heavy metals and make sure the CBD content matches what the company is advertising.
  2. Another good sign is if the company’s industrial-hemp products manufactured using the CO2 extraction method. Producing CBD oil by CO2 extraction doesn’t require any additional solvents or heat. This means that your CBD will be pure and potent.
  3. Above everything else, make sure the company you choose doesn’t make wild claims about the potential of CBD. If a company is claiming that their product cures cancer, it’s a very good sign that they should be avoided. CBD oils have many health benefits, but they are not a miracle drug.

If you follow the advice above, you’re on the right track to finding a trustworthy source for your CBD needs. This advice applies to any product sold online or in-store.

Online Shops

Purchasing CBD oil online is by far the most convenient method in Delaware. It allows you to choose and compare many different products within a matter of minutes.

Why leave the comfort of your own home when you can get quality CBD products delivered straight to your door?

Another benefit of online stores is they often allow you to take advantage of bulk discounts or special offers that local shops wouldn’t be able to match.

Most importantly, shopping online gives you valuable information about the companies and products they offer that may be difficult to obtain in a local shop.

Driving from store to store to compare products takes time. If you are more comfortable shopping in person, there may be a local retailer with CBD oil near you.

Take a look at our list below for stores in Delaware who can help you with your CBD needs.

Local Stores in Delaware

Delaware does have a limited number of dispensaries who can help those with medical marijuana licenses.

If you don’t have a medical marijuana license, you will have to see if your local vape stores, head shops, and natural health retail outlets carry industrial-hemp products.

There are hundreds of product available in-stores. Remember to double-check the source of your CBD oil so that you know your CBD oil is legal.

Follow the advice above to make sure you are getting a quality product.

What Is CBD Oil? Why Is It So Popular?

In the United States, CBD oil is a brand new and exploding industry. In 2017, over $190 million worth of CBD oil products were sold. There is a huge market for CBD oil as a health supplement.

Many states have been changing their marijuana laws. As of November 2018, 33 states have successfully implemented medical marijuana programs, and eleven have legalized marijuana for recreational use.

People slowly realize that marijuana products don’t cause “reefer madness” and it has many different medical applications.

CBD is a chemical compound found in marijuana and hemp plants that has several health benefits. It has been shown to treat seizures, inflammation, pain, and anxiety.

It can be extracted from both flowering marijuana plants and industrial hemp plants; this is an important distinction because the law views the two products differently.

CBD oil extracted from flowering marijuana plants contains higher levels of THC (tetrahydrocannabinol); this is the chemical in marijuana that causes the user to feel high.

On the other hand, Industrial-hemp derived CBD oil contains very little THC (usually no more than 0.3%) and therefore doesn’t cause the high usually associated with marijuana.

This means that you can take advantage of all the health benefits of CBD oil without getting stoned.

Recommended CBD Retailers in Delaware

Wilmington

  1. First State Compassion Center
  2. Nature’s Way Medicine
  3. Canna Care Docs
  4. VapeEscape
  5. Your CBD Store

Dover

  1. Puffster
  2. Blue Monkey Vapes
  3. Crystal Dragon Fine Smoking Accessories
  4. Maxed Out Vape
  5. First State Vape

Newark

  1. First State Compassion Center
  2. Delaware Vapor
  3. VapeEscape
  4. All in One Smoke Shop

Middletown

  1. RISE Dispensary
  2. Unreal Vapors
  3. Wesley’s Vape Shop

All of these stores should have helpful and knowledgeable employees who can point you in the right direction.

Final Notes on Buying CBD Oil in Delaware

Although Delaware has had trouble getting marijuana legalized, you shouldn’t have too many issues getting CBD oils in the state.

If you aren’t eligible for medical marijuana, you can still legally purchase industrial-hemp derived CBD oil without any concern from the authorities. There are a limited number of retail locations in the state who stock industrial-hemp derived CBD oil, so your best bet is to shop with a reliable online supplier.

Make sure you take the time to educate yourself about CBD because there are a lot of companies out there selling nothing but snake oil. Don’t get taken advantage of, do your research and buy online.

Although Delaware historically doesn’t have the most friendly marijuana laws, there are still options for purchasing CBD oil online.

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is cbd oil safe for pregnancy

U.S. Food and Drug Administration

What You Should Know About Using Cannabis, Including CBD, When Pregnant or Breastfeeding

FDA strongly advises against the use of cannabidiol (CBD), tetrahydrocannabinol (THC), and marijuana in any form during pregnancy or while breastfeeding.

A mother holding an infant, a pregnant woman holding baby shoes, a marijuana leaf and the letters CBD and the word WARNING

Cannabis and Cannabis-derived products have become increasingly available in recent years, with new and different types of products appearing all the time. These products raise questions and concerns for many consumers. And if you are pregnant or breastfeeding, you might have even more questions about whether these products are safe for you.

FDA strongly advises against the use of cannabidiol (CBD), tetrahydrocannabinol (THC), and marijuana in any form during pregnancy or while breastfeeding.

What are cannabis, marijuana, hemp, THC and CBD?

Cannabis is a plant of the Cannabaceae family and contains more than eighty biologically active chemical compounds. The most commonly known compounds are THC and CBD. One type of cannabis plant is marijuana, which contains varying levels of THC, the compound that produces the “high” that is often associated with marijuana. Another type of cannabis plant is hemp. Hemp plants contain extremely low amounts of THC. CBD, which does not produce a “high,” can be derived from either marijuana or hemp.

We are now seeing CBD-containing products everywhere. CBD can be found in many different products, like drugs, foods, products marketed as dietary supplements, and cosmetics. These products often make questionable health promises about CBD.

FDA wants you to know there may be serious risks to using cannabis products, including those containing CBD, if you are pregnant or breastfeeding.

What do we know about the effects of marijuana use during pregnancy and while breastfeeding?

There are many potential negative health effects from using marijuana and other products containing THC during pregnancy and while breastfeeding. In fact, the U.S. Surgeon General recently advised consumers that marijuana use during pregnancy may affect fetal brain development, because THC can enter the fetal brain from the mother’s bloodstream. The Surgeon General also advised that marijuana may increase the risk of a newborn with low birth weight. Research also suggests increased risk for premature birth and potentially stillbirth 1 .

While breastfeeding, it is important to know that breastmilk can contain THC for up to six days after use. This THC may affect a newborn’s brain development and result in hyperactivity, poor cognitive function, and other long-term consequences.

Additionally, marijuana smoke contains many of the same harmful components as tobacco smoke. Neither marijuana nor tobacco products should be smoked around a baby or children.

What do we know about the effects of CBD use during pregnancy and while breastfeeding?

There is no comprehensive research studying the effects of CBD on the developing fetus, pregnant mother, or breastfed baby. FDA is continuing to collect and study the data on the possible harmful effects of CBD during pregnancy and while breastfeeding. However, based on what we do know, there is significant cause for concern.

High doses of CBD in pregnant test animals have caused problems with the reproductive system of developing male fetuses 2 . In addition, based on what we already know about CBD, we expect that some amount of CBD will be transferred to babies through breast milk.

We also know that there is a potential for CBD products to be contaminated with substances that may pose a risk to the fetus or breastfed baby, including THC. We have also heard reports of CBD potentially containing other contaminants (e.g., pesticides, heavy metals, bacteria, and fungus); we are investigating this.

Moreover, CBD has known risks for people in general. Based on clinical studies in humans, risks can include the following:

  • liver toxicity (damage)
  • extreme sleepiness
  • harmful interactions with other drugs

FDA is studying the effects of CBD use from different angles, such as: (1) the use of CBD-containing products, like food, cosmetics, or supplements, over a person’s entire life; and (2) the effects of using these various products in combination. There are many unanswered questions about the science, safety, and quality of products containing CBD.

We especially want to learn more about the effects of CBD during pregnancy and while breastfeeding, including, for example, whether and to what extent the presence of CBD in human milk harms the breastfed baby or the mother’s milk production.

Has FDA approved any CBD products and are there any benefits?

FDA has not approved any CBD products except for one prescription drug to treat rare, severe forms of seizure disorders in children. It is still unclear whether CBD has any other benefits.

Other than the one approved prescription drug, CBD products have not been evaluated or approved by FDA for use as drug products. This means that we do not know:

  • if they are safe and effective to treat a particular disease
  • what, if any, dosage may be considered safe
  • how they could interact with other drugs or foods
  • whether they have dangerous side effects or other safety concerns

The clinical studies that supported the approval of the one available CBD drug product identified risks related to the use of CBD, including liver toxicity (damage), extreme sleepiness, and harmful interactions with other drugs.

What about hemp seeds?

FDA recently completed an evaluation of some hemp seed-derived food ingredients and had no objections to the use of these ingredients in foods. THC and CBD are found mainly in hemp flowers, leaves, and stems, not in hemp seeds. Hemp seeds can pick up miniscule amounts of THC and CBD from contact with other plant parts, but these amounts are low enough to not raise concerns for any group, including pregnant or breastfeeding mothers.

What should you remember about using cannabis or cannabis-derived products?

If you are considering using cannabis, or any products containing THC or CBD, you should be aware of the following:

  • FDA strongly advises that during pregnancy and while breastfeeding, you avoid using CBD, THC, or marijuana in any form.
  • Although many of these products are being sold, FDA has not approved these products, other than one prescription CBD drug product and two prescription drug products containing dronabinol, a synthetic version of THC (which are approved to treat certain side effects of HIV-AIDS or chemotherapy). All three of these prescription products have associated risks and side effects.
  • Always talk with your doctor, nurse, or pharmacist before taking any medicines, vitamins, or herbs while pregnant or breastfeeding.

Do not put yourself or your baby at risk by using cannabis products while pregnant or breastfeeding. Check out these links to learn more about cannabis, marijuana, CBD, and THC, and about taking medicines while you are pregnant.

FDA strongly advises against the use of cannabidiol (CBD), tetrahydrocannabinol (THC), and marijuana in any form during pregnancy or while breastfeeding.

Is CBD Oil Safe During Pregnancy?

CBD Oil is becoming increasingly popular for a variety issues, from pain relief, suppressing nausea, anxiety help to a restful night’s sleep. It’s understandable that a pregnant mom would consider taking it for pregnancy’s side effects. But is CBD Oil safe during pregnancy? Probably not.

What is CBD Oil?

Short for cannabidiol, CBD is found in marijuana and hemp plants. It doesn’t contain THC (tetrahydrocannabinol) so it doesn’t give you the intoxicating “high” associated with recreational marijuana. CBD oil is extracted and refined using ethanol to look like an actual oil. It’s available in a variety of products including pills, gels, gummies, vape oils, creams, and oral tinctures.

What do we know about the effects of CBD use during pregnancy and while breastfeeding?

There is no comprehensive research studying the effects of CBD on the developing fetus, pregnant mother, or breastfed baby. The FDA is continuing to collect and study the data on the possible harmful effects of CBD during pregnancy and while breastfeeding. However, based on what we do know, the FDA states there is significant cause for concern.

High doses of CBD in pregnant test animals have caused problems with the reproductive system of developing male fetuses. In addition, based on what they already know about CBD, the FDA expects that some amount of CBD will be transferred to babies through breast milk.

The FDA also states there is a potential for CBD products to be contaminated with substances that may pose a risk to the fetus or breastfed baby, including THC. They have also heard reports of CBD potentially containing other contaminants (e.g., pesticides, heavy metals, bacteria, and fungus); and are investigating this.

Moreover, CBD has known risks for people in general. Based on clinical studies in humans, risks can include the following:

• liver toxicity (damage)
• extreme sleepiness
• harmful interactions with other drugs

The FDA is studying the effects of CBD use from different angles, such as: (1) the use of CBD-containing products, like food, cosmetics, or supplements, over a person’s entire life; and (2) the effects of using these various products in combination. There are many unanswered questions about the science, safety, and quality of products containing CBD.

The FDA is planning to learn more about the effects of CBD during pregnancy and while breastfeeding, including, for example, whether and to what extent the presence of CBD in human milk harms the breastfed baby or the mother’s milk production.

Is CBD Oil legal?

Even though the government approves CBD derived from the hemp plant, individual states are changing their laws, which are not always the same as federal regulations. It’s important to check your state’s laws.

FDA has not approved any CBD products except for one prescription drug to treat rare, severe forms of seizure disorders in children. It states that it is still unclear whether CBD has any other benefits.

Should pregnant women use CBD oil?

The FDA strongly advises against the use of CBD on pregnant and breastfeeding women since research on the CBD’s safety among these populations is insufficient. It states on it’s website, “FDA strongly advises against the use of cannabidiol (CBD), tetrahydrocannabionol (THC), and marijuana in any form during pregnancy or while breastfeeding.”

The FDA further states “Do not put yourself or your baby at risk by using cannabis products while pregnant or breastfeeding.”

It’s understandable a pregnant mom would consider taking CBD oil for pregnancy’s side effects. But is CBD Oil safe during pregnancy?

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cbd oil for depression reviews

CBD Oil Reviews: A Compilation of User Experiences

Puya Yazdi

CBD Oil Reviews

If you’re thinking about trying CBD oil but aren’t sure if it’s worth it, we’ve got you covered. This post compiles hundreds of user reviews to distill the most valuable information. We review the effectiveness, adverse effects, and other practical aspects of different products on the market. Read on.

Disclaimer: This post only summarizes the reviews of users, who may or may not have medical or scientific training. We cannot attest to the accuracy and trustworthiness of the compiled reviews, which do not represent the opinions of SelfHacked. We recommend choosing CBD oil based on scientific evidence, preferably under medical guidance. Remember to discuss this with your physician before trying any CBD oil.

Why Compile CBD Oil Reviews?

According to the Mayo Clinic, the only approved use of CBD oil comes in the form of prescription anti-seizure medication and further research needs to be done to decipher its benefits in other conditions. But that has not stopped many people from using it for a myriad of conditions.

In fact, more and more people are using CBD oil for conditions such as chronic pain, anxiety, sleep disorders, and depression.

In addition to learning, if there is any scientific validity to its supposed benefits, an important part of the research is getting to know the first-hand experiences of other users. While personal experiences don’t translate into efficacy, these experiences might provide some warning on potential side effects you should be aware of.

The main questions you should ask before choosing a specific brand usually revolve around the following:

  • How effective are different products?
  • What side effects did other people experience?
  • What’s the best oil for your budget?
  • Which products are the easiest to use?
  • How reputable is the company you’re buying from?

Navigating CBD oil reviews can feel like going through a pitch-black maze, especially if you’re a first-time user. That’s why we decided to review hundreds of user experiences and compile the answers to all the important questions in one post. Remember, we encourage everyone to discuss with their physician before taking any supplements, let alone something like CBD oil which is a relatively new product on the market and has not had years of clinical research to back up its supposed benefits to health.

What Do People Use CBD Oil for?

The effectiveness and health benefits of CBD oil varied depending on the health conditions people used it for. We summarized user experiences for the main CBD oil uses below. Remember that these are just user experiences and your results vary. That is why it is very important to discuss CBD oil with your physician.

1) Seizures

People using CBD oil to control seizures or epilepsy in children mostly said that it acts quickly and gives good results.

According to users, CBD oil greatly reduced the frequency, duration, and severity of the seizures. What’s more, they reported fewer adverse effects than with conventional anti-seizure drugs.

2) Chronic Pain

Although not approved by the FDA, most people used CBD oil to relieve chronic pain.

They suffered from conditions such as arthritis, multiple sclerosis, fibromyalgia, surgical pain, migraines, and back pain. Some reported that the oil reduced pain and improved their quality of life.

In some cases, they reported added benefits such as helping them relax, lifting their mood, and improving their sleep quality. One person even claimed that she lost a few pounds from using it.

People with multiple sclerosis also reported reduced involuntary muscle contractions and tremors from taking CBD oil. In some cases, they claimed that the oil improved mobility and helped them walk without the aid of a device.

Those with arthritis reported that the oil relieved joint pain, stiffness, and inflammation. They felt increased arm and leg mobility, which allowed them to cut down on painkillers.

Approximately one-third of people with chronic pain used CBD to substitute opioid painkillers or lower their dose. They generally found CBD effective and didn’t experience the adverse effects and harsh withdrawal syndrome from these drugs.

3) Anxiety

A lot of people taking CBD oil suffered from severe anxiety, including social phobia, panic disorder, OCD, ADHD, and PTSD. In other cases, anxiety resulted from painful conditions such as fibromyalgia, IBD, and back pain.

In general, they were happy with the results and reported that the oil quickly made them feel more relaxed without getting them high.

Because anxiety often comes hand in hand with poor sleep, it’s not surprising that many users reporting that CBD oil reduced their anxiety also slept better afterwards.

4) Sleep Issues

Some users took CBD oil to improve insomnia or sleep issues that were a result of their anxiety and chronic pain.

Most say a single dose before going to bed helped them fall asleep faster and sleep through the night without feeling groggy or tired in the morning.

5) Depression

Few people took CBD oil for depression. Many, however, reported mood improvement as an added benefit to its effects on anxiety and pain. The oil supposedly helped them feel more joyful and optimistic.

What’s the Downside CBD Oil Users Talk About?

Although most CBD oil users were satisfied, some of them were left disappointed. They either didn’t feel anything or experienced side effects. This section compiles the main complaints.

Effectiveness

By far, the most common complaint among dissatisfied users was that the oil didn’t work for them.

In some cases, the reason might’ve been an insufficient dose. For instance, a user who vaped CBD oil felt that the dose per puff was too low and only felt some relief after repeated use. Another person with back and neck pain admitted not using CBD consistently.

Some complaints might be due to not using CBD oil properly. One user who took it for insomnia at 9 AM (instead of doing so before going to bed) complained about feeling drowsy two hours later but not at night.

A few users could have developed tolerance, since the oil stopped working after several weeks.

A person who took CBD for schizophrenia recommended low doses only when needed to avoid developing tolerance. Another person said he switched brands because he didn’t feel anything from the oil he was taking.

But for some users who even took the CBD oil properly, they said they didn’t get any benefits from the product.

Adverse Effects

Several users noticed unwanted effects from using CBD oil.

The most common side effects, regardless of the condition, were dry mouth, nausea, digestive issues, drowsiness, fatigue, and disorientation.

Some effects were specific to the condition or delivery form.

A woman taking CBD oil for anxiety reported having nightmares that caused her to wake up in panic attacks. In turn, another woman using CBD oil balm for arthritis developed a rash.

The risk of adverse effects increased at high doses. A user reported that a moderate CBD dose helped with her depression but not with chronic pain. When she doubled the dose, it still didn’t improve her pain and worsened her depression.

Similarly, several users reported headaches or irritability after taking high doses for a wide range of conditions.

CBD oil may also interact with prescription drugs. A man taking it for depression noticed that the oil increased his anxiety when he combined it with Xanax.

Other Aspects

Finally, many users complained about practical aspects unrelated to health, such as the brand and delivery form.

Most people complained about the high price of CBD oil.

However, satisfied users normally concluded that paying a bit more was worth it, since the more expensive oils were usually more effective, such as CBD oil from 4 Corners Cannabis. There were, however, some exceptions such as CBDistillery and Lazarus Natural Products. These brands offered high-quality oils at relatively low prices.

Many users found the customer service of some companies poor. Unresponsive or impolite staff, slow shipping, and payments processed through foreign banks (subjected to transaction fees) were the most common complaints. Pure Kana and Green Roads obtained the lowest rating, while the customer service of cbdMD was highly valued.

Some users experienced issues with the packaging: leaking bottles, droppers without marks to adjust the dose, and difficult-to-open containers.

A user of a THC-containing brand (Sunsoil CBD Oil) reported testing positive for marijuana after taking the oil. Conversely, several brands such as Hemp Bombs, Medterra, and Nature’s Script sell 100% THC-free products.

Several users of forms taken by mouth (including oil tinctures, vapes, and gummies) couldn’t stand the taste. In the case of topical forms, some users complained about their smell, greasy texture, and poor absorption through the skin. One user reported that the oil stained his clothes and wouldn’t come off.

Takeaway

CBD oil is considered experimental and more research is warranted before deciding on its effectiveness. Speak with your doctor before trying it out.

CBD oil reviews are extremely diverse, but a lot of users share positive experiences.

People say CBD oil relieves pain, anxiety, and seizures. Using it before sleep helped many users get a good night’s sleep. A handful of people also say it helps with depression and gut problems.

Some people claim CBD oil doesn’t work for them. In some cases, though, they admit using low doses or not taking the oil often enough. Others were taking CBD oil the wrong way, such as using it in the morning (instead of before bed) to improve sleep.

Users who complain about side effects — dry mouth, nausea, and drowsiness — were more frequently taking high doses.

Where you buy the oil from also matters. Many people complain about poor product quality, bad customer support, and packaging issues.

Experts are saying to avoid anything that causes inflammation during this Coronavirus pandemic, but some people have genes that make them more likely to experience inflammation. Check out SelfDecode’s Inflammation DNA Wellness Report for genetic-based diet, lifestyle and supplement tips that can help reduce inflammation levels. The recommendations are personalized based on YOUR DNA.

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Carlos Tello

Carlos Tello

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Contents

Joe Cohen, CEO

Joe Cohen won the genetic lottery of bad genes. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine.

If you’re just about to try CBD oil, read this post first. We compiled hundreds of user reviews to get the most valuable information.

Best CBD Oil for Anxiety: Benefits and Top Brands for 2021

Royal Purity

Anxiety in itself isn’t anything bad. In fact, it’s a healthy reaction that humans have developed over the course of evolution as a protective mechanism against other predators.

Also known as the “fight or flight response,” anxiety can happen from time to time and is completely normal.

However, modern times are putting so much pressure on our shoulders that we are driven into anxiety on a daily basis—even though we face no life-threatening dangers.

Plants and herbs are known for their relaxing properties, but cannabis plants seem extremely helpful in curbing symptoms of anxiety and other stress-related disorders.

But how to find a high-quality product if you’ve never bought CBD oil before? How do you find a reputable brand in the sea of mediocre companies?

5 Best CBD Oils for Anxiety

In this guide, you’ll learn about the best CBD brands on the market today and everything you need to know about the benefits of CBD for anxiety disorders.

After hours of research, we’ve narrowed down this list to the top five vendors so you wouldn’t have to spend the same amount of time comparing prices, reading reviews and trying out all possible CBD oils

Check out the recommendations below.

1. Royal CBD – Top Pick

Royal Purity CBD

Our top pick, Royal CBD is a premium brand rooted in California that offers excellent value for money. Considering the wide potency selection of their CBD oil, the way the company processes its products and the effort put into testing its CBD range, it’s hands down top shelf.

Royal CBD oil is available in four strengths: 250 mg, 500 mg, 1000 mg and 2500 mg. Such a wide range of potency options makes this oil suitable for both new and experienced consumers alike.

This is a full-spectrum extract, so you’re getting the entire array of non-psychoactive cannabinoids, terpenes, flavonoids and only trace amounts of THC (below 0.3%).

Unlike many competitor brands, Royal CBD uses carbon dioxide in its supercritical form to extract the CBD oil. The CO2 runs through the plant material under different temperatures and pressure levels, changing its state from gas to liquid. From there, it diffuses into the air, leaving behind a cold, liquid extract.

All Royal CBD products are submitted to independent laboratories for extensive content analysis to ensure they’re safe to consume. The company also offers free shipping, as well as full refunds, for customers who aren’t satisfied with the product.

2. Gold Bee – Runner Up

GoldBee

Gold Bee is a true maverick among other CBD brands. The company offers organic-only CBD oils made from locally sourced hemp grown in Colorado. Although Gold Bee focuses on low-to-mid potency oils (up to 1200 mg of CBD per bottle), their formula has been mastered to perfection.

The guys at Gold Bee even use honey as a sweetener in their flavored versions of CBD oil. If you’re new to CBD, or have some experience but don’t need more than 40 mg CBD daily, their oils are among the best natural remedies for stress. You can also choose from Gold Bee’s high-potency capsules and delicious CBD-infused honey sticks.

3. CBDistillery – Runner Up

CBD Distillery

CBDistillery has been on the market for about six years now, upholding its reputation as one of the best CBD brands in the world. The company has an impressive selection of CBD oils, available as full-spectrum or pure oil (isolate).

You can choose from five different strengths, from 250 mg to 5000 mg of total CBD. But the best part about CBDistillery is that its products are highly affordable. The company’s mission is to provide education and access to CBD products for everyone who needs them. For example, the 250 mg bottle costs only $20, which is a great deal. For $240, you can get your hands on the maximum potency.

The only downside about this oil is that it’s not made from organic hemp, but considering the affordability of CBDistillery products, this is a minor disadvantage.

All in all, CBDistillery doesn’t sell the best CBD oil out there, but its extracts are without parallel in this price category.

4. NuLeaf Naturals

NuLeaf CBD

NuLeaf CBD oil is another veteran company, but unlike CBDistillery, it only makes full-spectrum CBD oil. Despite the modest product line up, the quality of the NuLeaf Naturals CBD oil is top-notch.

The oil is available in different sizes, from 240 mg to 4850 mg. We say “sizes” because each “potency” comes in a different bottle size. You actually get the same strength regardless of the size, so your choice here will be determined by the time you want to get yourself supplied for.

Another great thing about NuLeaf Naturals is that it uses organic hemp for all of its products. Each batch is tested by a certified lab to ensure that they deliver consistent potency and desired effects.

The oil is slightly bitter and nutty in taste because it uses full-spectrum CBD.

5. Charlotte’s Web

Charlottes Web CBD

Charlotte’s Web is an almost legendary company, established by the Stanley Brothers, whose cannabis oil helped young girl Charlotte Figi come down from several seizures a day to a few attacks a month.

Charlotte’s Web CBD oil is certified by the U.S. Hemp Authority, ensuring it meets the highest quality standards.

The company’s products come from organic, non-GMO plants and are extracted with olive oil.

The oil is available in three concentrations, 300 mg, 750 mg, and 2580 mg, so the potency range is similar to Royal CBD. It has a dark green color and viscous consistency, which is a good indicator of its strength and overall quality.

You can choose between 30 ml and 100 ml bottles.

6. CBDPure

CBD Pure

Almost every list of the best CBD oils on the market includes CBDPure. Unsurprisingly, we won’t break that pattern.

CBDPure is known for producing high-quality CBD products as well as unparalleled transparency. The CBDPure Hemp Oil has been extracted with CO2 and thoroughly filtered from the plant material, so it has a nice golden yellow color. However, it tastes surprisingly tart—a bit worse than other brands.

You can choose between three different strengths: 100 mg, 300 mg and 600 mg. The lowest potency provides 3.3 mg of CBD per serving. However, these are full-spectrum oils, so you get the synergistic effects from all cannabinoids and terpenes—resulting in lower effective doses.

What Is Anxiety?

As mentioned at the beginning, anxiety is a normal human response to dangerous stimuli. The “flight-or-flight” response covers an array of physical reactions, such as a rush of adrenaline, sweating, increased heartbeat and sensitivity to environmental triggers.

When the anxious feeling gets exaggerated compared to the seriousness of the trigger, the anxiety may turn into an anxiety disorder.

Once at that stage, the anxiety deteriorates to the point when a person’s daily function and mental health are heavily affected.

Common Types of Anxiety Disorders

There are four main types of anxiety disorders:

  • Generalized Anxiety Disorder: This is a chronic ailment in which people get anxious for no specific reasons. It’s considered the most common anxiety disorder.
  • Phobias: Phobias induce overwhelming fear about a specific situation or object. They often prevent people from engaging in normal situations due to that fear.
  • Social Anxiety Disorder: This condition usually occurs when a person is among other people. It triggers an overwhelming worry about social interactions, causing fixation on being judged.
  • Panic Disorder: Panic attacks strike randomly and are accompanied by symptoms like breathing difficulty, shaking, dizziness, tremors, confusion and nausea. It can last anywhere between a few minutes to an hour.

Symptoms of Anxiety Disorders

Wondering how to tell if you’re suffering from one of the above anxiety disorders? Below we share the full list of symptoms:

  • Dizziness
  • Dry mouth
  • Inability to stay calm
  • Feelings of insecurity
  • Heart palpitations
  • Panic
  • Sleep problems
  • Somatic complaints
  • Tense muscles

What Causes Anxiety?

Anxiety disorders are very complex. Usually, there are several factors involved, including:

Genetics

If you have a family member diagnosed with an anxiety disorder, there’s a risk that you may develop the same condition.

Changes in Brain Structure

Suffering from a traumatic events or genetic changes of the brain may cause an overexaggerated response to potentially neutral triggers. Scientists suggest that the majority of anxiety disorders derive from compromised communication between neurons.

Environmental Factors

Certain elements of your environment can worsen your anxiety. Some of the stress-inducing factors include chronic stress at work, at school or even at home. Sometimes, things like a bad financial situation or the loss of someone who was very close to you can also contribute to this medical condition.

When you don’t get enough sleep, it can also make your anxiety worse.

Just as traveling to high altitude areas, where the brain gets affected by low oxygen levels.

Medical Conditions

Sometimes, anxiety can result from another medical condition, prescription medications or health supplements you’re taking, or any other disease than can either change the structure of your brain or cause you to suffer from severe stress.

Can CBD Oil Help With Anxiety?

Dealing with anxiety can be a real pain.

For one, conventional anxiety treatments are very expensive, and their cost is continuously rising. If you want to get those meds prescribed to you, you’ll have to cover the cost by yourself before the insurance covers some part of it.

Not to mention that many prescription drugs used to manage anxiety can lead to a range of negative side effects. Don’t take our word for it, just see the list of contraindications or possible negative reactions on any popular medication, and you’ll see that it’s worse than what they’re trying to solve.

Of course, if you’re meds are helping you, and you don’t feel the need to make any changes, that’s fine. But some people either can’t take medications due to allergies or their anxiety just isn’t bad enough to qualify for prescription treatment.

It’s no wonder that some anxiety sufferers are turning to natural resources for relief.

CBD oil is one of them.

But the question is: Can CBD actually help with anxiety?

Research and a large portion of evidence from people with anxiety suggests that CBD oil may even be a better alternative to pills and shots for anxiety. Compared with those options, CBD oil has a low risk profile and the side effects are nearly nonexistent unless taken in extremely high doses.

How Does CBD Work?

Why is CBD oil a good option to consider as an alternative anxiety treatment?

Because CBD regulates the body’s endocannabinoid system, which is the most important neurochemical network inside the body—it controls vital functions, such as memory, mood, sleep, immune response, cognition, appetite, pain and more.

When the body is in homeostasis—a fancy word for chemical balance—it can stay in good health.

However, if there are imbalances in your neurochemicals, they may give rise to anxiety. It also works the other way round; when you suffer from a traumatic event, your receptors and neurons get out of whack, and your body starts to seek something that would restore that balance.

This is where CBD starts to shine.

CBD and the 5-HT1A Receptor

CBD is a 5-HT1A agonist. In other words, 5-HT1A works a serotonin receptor and is responsible for the way your body absorbs serotonin.

It’s also the target of the most popular antidepressants and anti-anxiety drugs, which belong to the group of Selective Serotonin Reuptake Inhibitors (SSRIs).

SSRIs can block the reuptake of serotonin, increasing the brain’s ability to transfer more signals, improve mood and curb anxiety. CBD has a similar effect on 5-HT1A.

CBD and Hippocampal Neurogenesis

Your hippocampus is the region in your brain that modulates several functions. One of them is the ability to regenerate neurons. CBD can help stimulate the hippocampus and thus improve its functioning.

This is particularly important for patients diagnosed with anxiety, as they often show smaller hippocampus plasticity. By stimulating the regeneration of neurons, there’s a chance that fearful behaviors will be minimized.

CBD and GABA

Australian scientists have found that CBD is a “positive allosteric modulator” of the GABA-A receptor in the brain.

In simple terms, GABA is the main inhibitory neurotransmitter in the human central nervous system. It works as the handbrake for our brain to slow the nervous system down when we get too agitated. The sedating effects of Valium and other benzodiazepines are triggered by their interaction with the GABA-A receptor.

By modulating this receptor, CBD can amplify the natural calming effect of GABA and reduce anxiety.

CBD and Anandamide

Anandamide is one of the two main endocannabinoids (produced inside your body). It has almost the same structure as THC, the main psychoactive compound in cannabis.

Anandamide is also known as “the bliss molecule,” as it controls feelings of happiness, euphoria, and keeps us in emotional stability—on top of many other functions. CBD helps keep the levels of anandamide at the right level, reducing mood swings and emotional outbursts.

Studies on CBD Oil and Anxiety

Anxiety is one of the best studied areas when it comes to using CBD oil.

A 2010 study on social anxiety showed that CBD has the potential to reduce symptoms in people diagnosed with a social anxiety disorder. The substance also changed the way the patients reacted to anxiety—of course, in a positive way.

In a 2014 study, scientists concluded that CBD has anti-anxiety and antidepressant effects. Although the study was conducted on rat models, it gave an interesting insight into the management of anxiety disorders in humans.

CBD was also highlighted in this 2015 report published in Neurotherapeutics as the next potential treatment for anxiety disorders and its symptoms.

It’s worth noting that all of the above studies examined high-quality pure CBD oil. This is particularly important for our next section.

What Determines the Quality of CBD Oil?

CBD oil isn’t regulated by the FDA in the United States. Even though it may be more effective in managing anxiety disorders than conventional treatment options, it’s still considered a health supplement—not a medication.

Similar to other food supplements, it may be difficult for consumers to know if the CBD oil they’re using is actually pure.

You could be taking CBD-laced oil full of synthetic additives and you wouldn’t even know it because supplements aren’t subject to obligatory lab testing, unlike prescription anxiolytics.

If you want to make sure that you’re getting exactly what you’re buying, you’ll need to learn how your oil was manufactured. This includes the following elements:

Hemp Source

Cannabis plants have the ability to absorb anything from their environment. When grown in contaminated soil and treated with pesticides, they will yield weak and contaminated extracts.

If you want a pure and potent oil, always buy from companies that use organic hemp plants, preferably those cultivated on American farms.

Extraction Method

Brands have different extraction methods and ways of processing CBD extracts. As much as possible, choose brands that employ supercritical CO2 extraction, as it’s considered the safest and the most effective way to obtain CBD oil.

Avoid companies that use toxic solvents such as butane or propane, as they carry a high risk of contamination due to the unpurged residue at the bottom of the oil.

Third-Party Lab Tests

Trustworthy CBD oil brands should proudly publish third-party lab results on their websites or attach them to the product’s package. Third-party testing ensures that your oil contains exactly what’s written on its bottle—they analyze the potency of CBD and look for common contaminants in the end product.

Getting a CBD product tested by an independent laboratory will serve as evidence of its quality.

How to Use CBD Oil for Anxiety

One of the most common questions about using CBD oil for anxiety is “How much CBD oil should I take?”

There are no official guidelines because everybody reacts differently to CBD. Factors such as the individual’s age, weight, severity of symptoms and lifestyle choices can affect your effective dose.

Dosing CBD oil for the first time requires some trial and error. For maximum safety, consider the following steps:

  • Take basic measurements such as your weight and height.
  • Determine the severity of your anxiety on a scale from 1 to 10.
  • Start your supplementation with one drop of CBD oil.
  • Increase your dosage slowly by, say, two drops each day for a few weeks and write the effects down. Monitor how you react to CBD with every single dose.
  • Don’t rush it. Sometimes, the effects of CBD are almost immediate, but for most people, dramatic changes in the way you feel become noticeable after a few days or weeks.
  • Consult your doctor before buying any CBD product. This will help you make sure that there are no drug interactions between CBD and other medications if you take them together.
  • A study on social anxiety reports that 600 mg is an effective dose in relieving the condition. However, there are also studies that recommend taking much lower doses to improve the symptoms.
  • If you suffer from severe pain and sleep problems , you may need to take higher doses of CBD because it affects these areas of your well-being as well.
  • Some people dislike the taste of CBD oil and feel uncomfortable with taking the supplement in this form. If you’re one of them, opt for other formats, such as capsules, vape oils, or CBD gummies .

Possible Side Effects of CBD Oil

CBD oil is considered generally safe and poses no threat of addiction, according to the World Health Organization.

The side effects of CBD oil are mild and include:

  • Dry mouth
  • Temporary drop in blood pressure
  • Dizziness
  • Sedation (in high doses)
  • Diarrhea (from large amounts of oil)

The main risk about using CBD oil for anxiety is the lack of regulation by the FDA. Without regulation, you’re putting yourself at risk of exposing yourself to synthetic cannabinoids or toxic additives in your extract without even knowing it.

Another potential concern is the aforementioned interaction between CBD and medical drugs. CBD engages with them in a similar fashion as grapefruit juice. With that in mind, we suggest that you talk to your doctor first, particularly if you have any other ongoing medical conditions.

If your doctor gives you the green light, you can start looking for CBD oil online or locally.

Final Thoughts on Using CBD Oil for Anxiety

Managing anxiety with CBD oil has become popular these days. With a growing body of evidence backing the positive effects of CBD on an individual’s mental health, it’s not surprising that more and more people are turning to CBD for help.

If you’re planning to buy CBD oil online or in local shops near you for your anxiety symptoms, make sure it comes from a reputable brand that’s open about its manufacturing practices and has lots of positive reviews.

CBD oil is also effective in managing other functions, such as blood pressure, sleep cycle and glucose levels.

It’s a good choice if you want to live a healthy and happy life.

Best CBD Oil for Anxiety: Benefits and Top Brands for 2021

We hope that you’ll find this guide useful for your future purchases!

Thousands of people use CBD oil to fight stress and anxiety. If you’re looking for the best CBD oil to ease your symptoms, then this guide is for you.

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cbd oil and blood pressure meds

Blood Pressure Medication and CBD Oil Interaction

Written by Jason Brett — Edited by Cathy Rozyczko on February 9, 2021

A growing number of Americans are turning to cannabidiol (CBD) to address a wide range of concerns from stress and anxiety, to pain and inflammation. But, with so many people using CBD oil, questions start to arise about potential interactions with common prescriptions, including blood pressure medications.

If you rely on blood pressure medication and want to use CBD oil as an alternative or supplement to your current treatment plan, here is an overview of everything you need to know about using CBD oil while taking blood pressure medications.

CBD Oil and Blood Pressure Medication Interaction

Because there are such a wide range of pharmaceuticals prescribed for lowering blood pressure, it’s impossible to speak in broad terms about how CBD oil interacts with them all. However, if you’re taking one of the more common medications for hypertension (valsartan, metoprolol beta blocker, lisinopril, amlodipine besylate, or hydrochlorothiazide), there are a few things you should take into consideration before using cannabidiol oil.

CBD oil is generally recognized as a safe and well-tolerated compound with little to no known side effects. However, while conclusive studies have not been published, it has been suggested that CBD oil may affect the efficacy of blood pressure medication in controlling hypertension. Conversely, blood pressure medication is also believed to potentially reduce the efficacy of CBD oil.

Furthermore, because cannabidiol is an inhibitor of the cytochrome P-450 enzyme system , CBD oil should be used cautiously when combined with medications that use this pathway; in the case of high blood pressure medications, metoprolol and amlodipine besylate specifically.

The cytochrome P-450 system is comprised of liver enzymes that break down medications into smaller substances that the body can more easily process. Cannabidiol and other natural substances like grapefruit slow down this pathway. This may cause medications that rely on the P-450 system, including metoprolol and amlodipine besylate, to remain for longer periods in the system and increase the likelihood that you experience their adverse side effects.

Side Effects of Using CBD Oil and Blood Pressure Medication

While adverse interactions between CBD oil and blood pressure medication are rare, they should be combined with caution and only under doctor supervision. In some cases, blood pressure medications may delay and/or reduce the beneficial effects of CBD oil. In others, CBD oil may delay and/or reduce the effectiveness of your prescribed blood pressure medication.

For reference, this table breaks down a few of the more common blood pressure medications and the side effects you may feel if taking them in conjunction with CBD oil.

Generic Name (Brand Name) Possible Side Effects of Combining Medication + CBD Oil
Valsartan (Diovan) CBD oil may be metabolized slower when used in conjunction with Valsartan
Metoprolol (Lopressor; Toprol XL) The antihypertensive function of Metoprolol may be decreased when combined with CBD oil
Lisinopril (Prinivil; Zestril) The antihypertensive function of Lisinopril may be decreased when combined with CBD oil
Amlodipine besylate (Norvasc) CBD oil may be metabolized slower when used in conjunction with Amlodipine besylate
Hydrochlorothiazide (HCTZ) The antihypertensive function of Hydrochlorothiazide may be decreased when combined with CBD oil

Another important thing to note is that since CBD oil reduces blood pressure on its own, when it is taken in tandem with medication designed to perform the same action, you essentially have two compounds bringing down your levels. If your blood pressure is reduced too much in a short amount of time, you may feel weak and lethargic. It is for this reason that starting with a small initial dosage of CBD is key.

Avoiding the Side Effects

With the above possible side effects in mind, you may feel dissuaded from trying CBD oil while on blood pressure medication. On the other hand, you might also consider using CBD oil on its own to manage hypertension. Amongst other benefits, CBD oil has been shown to reduce blood pressure by relieving anxiety, reducing stress, and widening blood vessels.

CBD oil’s anti-anxiety and stress-relieving properties encourage a lower heart rate, which ultimately reduces blood pressure. CBD oil’s ability to dilate blood vessels allows for easier blood flow in arteries with plaque build-up, which also reduces the symptoms of hypertension. In fact, a 2017 study found that a single dose of cannabidiol significantly lowered the blood pressure of test subjects both when at rest and in stressful conditions.

In a cumulative 2017 review of numerous studies on cannabidiol’s effect on blood flow, it was concluding that “ CBD may be used as a treatment for various cardiovascular disorders, such as hypertension, myocardial infarction, and stroke.” It is important to mention that the majority of these results were found in animal studies and more clinical research is needed in humans. Still, the findings are promising.

How to Safely Use CBD Oil and Blood Pressure Medication Together

Whether your goal is to supplement your current hypertension treatment plan with CBD oil, or to completely replace your blood pressure medication with CBD oil, you should begin by speaking with your doctor . Because CBD oil can interact with your current blood pressure medications, consulting with your physician on the possible risks—and benefits—is crucial for your safety and health.

You will want to be conscientious of dosage especially since CBD oil may amplify the effects of the medications you’re taking. CBD products generally come with an information leaflet that provides a recommended dosage, but you may want to start with an amount lower than what is recommended and gradually increase your dosage over time as needed. This will allow your body to build a tolerance to CBD oil and reduce the risk of having a sudden drop in your blood pressure.

For more information on proper CBD oil dosage, check out our dosage guide here .

Over a period of time, you may even find you are able to lower the dosage of your blood pressure medication as the CBD oil becomes most effective. If you choose to do this, speak to your doctor before discontinuing or altering your prescription medication. Any changes to your treatment plan are best done under the supervision and guidance of a medical professional.

If you’re still in need of guidance or would like more information on using CBD oil as a medical supplement, consider speaking with a naturopathic doctor who specializes in natural health treatments.

Best CBD Oil to Use with Blood Pressure Medication

In order to find the best CBD oil product, you need to know what you’re looking for. With thousands of products available online and in stores, how do you know where to start?

First, investigate the different CBD oil delivery formats to decide which one best fits your goals and lifestyle. CBD oil drops, edibles , capsules, and vapes a few of the more common options.

While the majority of people new to CBD oil opt for capsules and edibles because of their convenience and familiarity, it is worth keeping in mind that these will enter your body through the digestive system and therefore lose some potency and take longer before you feel the effects. Inhalants or sublingual drops meanwhile, allow the CBD oil to enter the bloodstream more readily, providing quick and effective results. Experiment with the different delivery methods to decide which works best for your needs and lifestyle.

Once you have decided on your preferred delivery format, look for top-rated CBD oil products that are sustainably sourced, organically grown, and third-party lab tested to ensure quality and purity. Taking these steps is the best way to ensure that your CBD oil product is free from any harmful pesticides, herbicides, and added chemicals.

And when you’re ready to shop, check out our list of the Top 10 Best CBD Products to Buy.

If you found this article helpful you may also be interested in:

Can CBD oil help treat hypertension? And is it safe to take with existing blood pressure medications?

Does CBD Oil Lower Blood Pressure? What the Research Says

With stress in the U.S. on the rise, it’s no wonder more than half of Americans suffer from high blood pressure.

woman wearing jean jacket filling a dropper with CBD oil, black CBD oil bottle

CBD oil has been hailed as a cure-all for a variety of conditions, but what do researchers have to say about CBD oil and blood pressure?

Does CBD oil lower blood pressure, or is it an unfounded claim? Is it possible to skip the burdensome doctors’ visits and expensive trips to the pharmacy?

We wouldn’t go that far. Hypertension is a risk factor in heart attack, stroke and type 2 diabetes. Even though it’s common, it’s a serious issue which require medical attention.

However, there are many steps you can take to naturally reduce your blood pressure, one of which may be by using CBD oil for hypertension.

What is Hypertension?

Hypertension is the medical term for high blood pressure. As blood is pumped through your blood vessels, they undergo a degree of force. If you have high blood pressure, this force can damage the walls of your blood vessels, veins and arteries.

When you visit the doctor, you’ll usually hear your blood pressure described by two numbers, like 120/70.

The first number refers to the systolic pressure, the pressure exerted when the heart contracts and pumps blood into the arteries. The second is the diastolic pressure, measured when the heart muscle relaxes between beats. In cardiology, a systolic pressure of 140, and/or a diastolic pressure of 90, is considered the boundary between normal and high blood pressure.

High blood pressure can lead to cardiovascular complications such as heart disease, heart attack, stroke, aneurysm and heart failure. The condition is exacerbated by type 2 diabetes, stress, anxiety, inflammation, high cholesterol levels, insomnia, a diet high in salt, and alcohol and tobacco use.

Lowering High Blood Pressure: CBD and Blood Pressure

High blood pressure can be naturally lowered by reducing stress, salt intake, and consumption of alcohol and tobacco. You can also lower your blood pressure by exercising regularly and eating more fruits and vegetables.

Your doctor may prescribe medications that can lower blood pressure. Many of these medications, such as calcium channel blockers and ACE-inhibitors, cause side effects like headaches, dizziness, constipation and swollen ankles. That has naturally sparked interest in non-prescription treatments for high blood pressure.

New evidence links CBD to a decrease in blood pressure. For many people, CBD oil has fewer side effects than prescription medications, too.

We spoke with Rebecca Park, registered nurse and founder of RemediesForMe.com, who told us that CBD oil tinctures made using hemp have very few side effects and are generally well tolerated.

If you are already on high blood pressure medications, however, consult your physician before using CBD oil as there may be interactions.

What is CBD Oil?

Cannabidiol, better known as CBD, is a non-psychoactive phytocannabinoid, which is a cannabinoid found in the two forms of cannabis, marijuana and hemp plants.

Commercially-available CBD oil is cannabidiol extracted from the hemp plant, often mixed with coconut or hemp oil. Unlike its marijuana-derived counterpart, this CBD oil does not contain high levels of tetrahydrocannabinol (THC), so cannabidiol does not get you high. Instead, most users report that it makes them feel relaxed and calm, among the other generally positive effects of CBD.

According to federal law, hemp-derived CBD oil is classified as having less than 0.3% THC, making it legal to purchase and use. And since hemp has minuscule amounts of THC content, CBD oil from this type of cannabis plant does not cause any of THC’s intoxicating side effects. Marijuana-derived CBD oil, whether it’s derived from sativa or indica-dominant plants, contains more than 0.3% THC as its primary active ingredient, and may make you high. It is only legal in states with recreational or medical marijuana legalization.

Though it comes in a wide variety of forms such as capsules, vape juice, powders, topical patches and lotions, and edibles like gummies, cannabidiol is most popularly consumed as a sublingual oil. You simply place a few drops of CBD oil under your tongue and let it sit for 30 to 90 seconds.

Pharmacology research has shown a wide range of potential benefits for cannabidiol. CBD oil is commonly used to treat or supplement treatment of medical conditions like chronic pain, inflammation, arthritis, multiple sclerosis, Parkinson’s disease and epilepsy. Park added that CBD oil is also commonly used by people suffering from a wide range of mental disorders.

“CBD can be effective in treating generalized anxiety disorder (GAD), social anxiety disorder, anxiety related insomnia, and post-traumatic stress disorder (PTSD),” she said.

Additionally, emerging evidence shows that CBD may use the same mechanism to treat high blood pressure as it does to reduce anxiety.

How CBD Interacts with the Endocannabinoid System and Body

The endocannabinoid system is a biological system in your body that allows cannabinoids to send and receive messages that control most of the body’s important functions. In fact, your body naturally produces cannabinoids every day.

This system has two main endocannabinoid receptors, called CB1 and CB2. THC binds directly to the CB1 receptors, affecting areas of the brain that influence memory, motor coordination and time perception, and to the CB2 receptors which affect the pain centers in your brain and manage inflammation in the body. The interaction between THC and the endocannabinoid system is what causes the psychoactive side effects that marijuana is best known for.

On the other hand, cannabidiol does not directly bind to the CB1 and CB2 receptors. Instead, it causes a number of indirect actions leading to therapeutic benefits, such as activating TRPV1 receptors that regulate pain, body temperature, and inflammation.

Does CBD Oil Lower Blood Pressure?

While Park told us that high blood pressure can be caused by a number of factors, CBD oil appears to lower increases in blood pressure caused by stress and anxiety.

She explained that when emotional or physical stress is high, our bodies release a hormone called cortisol. High levels of cortisol can raise blood pressure.

“CBD lowers blood pressure by reducing cortisol levels and dilating blood vessels, allowing more blood flow and leading to lower blood pressure,” Park said.

Park pointed to a study of 11 participants that showed CBD oil may lower the levels of cortisol produced in the body. This study showed that volunteers saw a significant reduction in cortisol production when given 300 mg and 600 mg of CBD compared to the placebo control.

In a famous 2017 randomized crossover study led by British doctor Khalid Jadoon and published in the Journal of Clinical Investigation (JCI), a single dose of 600 mg of CBD oil or a placebo was administered to nine healthy volunteers. The resulting data showed that acute administration of CBD reduced resting blood pressure compared to placebo dosing.

The patients were then given a series of stress tests to increase heart rate. Those who were given 600 mg of CBD had lower stress-induced blood pressure spikes than the control group.

It’s amazing, but it’s true. A single dose of cannabidiol lowered the blood pressure of patients, whether they were resting or under stress.

The sample size of these studies was small and further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders, but the results are promising.

How CBD Can Help With Hypertension

As Park explained, high blood pressure can be caused by many factors. Fortunately, there are several health benefits of CBD that could indirectly help with hypertension.

Anti-Anxiety

Anxiety can lead to rapid heart rate and palpitations, leaving you at risk for high blood pressure and heart disease.

CBD oil has been shown to reduce anxiety in animal studies by the National Institute for Drug Abuse (NIDA). This study demonstrated that symptoms that accompany anxiety, like high blood pressure and rapid heart rate, were improved by use of CBD.

Reduces Inflammation

Inflammation doesn’t only occur in your joints. In fact, research shows that CBD oil can reduce inflammation in the heart and blood vessels in the brain.

Called a “vasorelaxant” by researchers, CBD oil’s anti-inflammatory properties may lower blood pressure by allowing the free flow of blood through your heart, arteries and veins.

Analgesic Properties

According to the National Institutes of Health (NIH), acute pain can lead to high blood pressure. Because CBD acts on the pain receptors in the brain, the pain-relieving properties of CBD could lead to decreased blood pressure.

CBD Improves Sleep

As CBD reduces stress, you may see an increase in your quality of sleep and general wellness.

Sarah Polansky, owner and developer of the CBD brand Prismatic Plants, told Public Goods that “The more you take CBD and help to regulate your adrenals, the less likely you’ll feel fatigued as your body returns to a state of balance rather than constant stress.”

She added, “This means your need for caffeine consumption could decrease and your quality of sleep could improve, which has a waterfall benefit for increasing overall health.”

Choosing CBD Oil for High Blood Pressure

No prescription or documentation is needed for CBD oil. The only exceptions are the marijuana-derived CBD oil sold in dispensaries (in medical marijuana states, you’ll need a patient card to buy it) and a medication called Epidiolex, a CBD medication only available by prescription to patients suffering from some forms of childhood epilepsy.

All of the forms of CBD that you can buy over the counter are not generic products. Their effectiveness depends largely on the quality of the manufacturer producing it, and the type of CBD that’s used.

Many of the cannabidiol products you’ll see in CBD stores or online are of lower quality, since – as with any product – it’s more expensive to produce high-end merchandise and it sells for a higher price, often with lower profit margins for the vendors.

High-quality CBD oil, capsules, topicals, juice for vaping, or edibles will always produce a better result, so it’s best to do a little research to find reputable vendors who create effective products. Look for oil sourced from Colorado or West Coast organic hemp, extracted with high-end methods (like supercritical CO2 extraction), and containing only a small number of natural or organic ingredients required for flavoring or distributing the cannabidiol (the latter is done via MCT coconut carrier oil in high-quality CBD).

Some cannabidiol delivery methods work more slowly than others.

Capsules and edibles, for example, must make their way through the digestion process before the CBD can be released into the blood stream and carried throughout the body. Vaping or administration under the tongue make the cannabidiol available almost immediately, since it’s absorbed quickly by the sublingual glands or tissues in the lungs. And topical CBD usually doesn’t even make it into the bloodstream, since it’s blocked by the epidermis.

When shopping for CBD oil, you’ll find there are three different types to choose from.

  • Full-spectrum CBD is the most effective. It contains all of hemp’s natural terpenes and flavonoids, as well as all of the cannabinoids in the plant – including the small amount of THC we’ve mentioned. They all work together in the so-called “entourage effect” that boosts CBD’s performance.
  • Broad-spectrum CBD provides a slightly lower entourage effect, because the THC content has been removed from the cannabidiol before it’s processed and sold.
  • CBD isolate goes a step further. All of the components of hemp except cannabidiol are removed, leaving only pure CBD in the final products.

Some people believe that pure cannabidiol does the most good, but in reality, there’s only one reason to avoid CBD that contains THC: it eliminates any chance of turning up dirty on a drug test for marijuana. In reality, very few full-spectrum CBD users ever test positive, but some people’s minds are set at ease by knowing there’s no THC in their body.

What’s The Best CBD Dosage for High Blood Pressure?

Because the FDA has not approved over-the-counter CBD products, there is no official recommendation for a dose of CBD. The right dose depends on your weight, genetics, sex and medical history. More studies need to be conducted with human subjects to get an accurate dosage.

Many CBD oils come in dropperful (1 ml) doses of 10 mg/ml. Cannabidiol affects different people, particularly based on the weight, metabolism and body type. However, Park said the effective therapeutic dose is usually in the range of 20 mg to 300 mg, or 2 to 30 dropperfuls.

In a 2018 study, researchers found that a dose of 300 mg was most effective for reducing anxiety in a simulated public speaking trial. Participants who took 150 mg or 600 mg did not receive the same benefit.

Meanwhile, in the previously-mentioned study of nine healthy volunteers, blood pressure was effectively lowered with a single dose of 600 mg.

The best way to determine how effective a dose of CBD will be for you is to start small and frequently check your blood pressure using an electronic cuff. Write down the dose you took and the time you took it, as well as your blood pressure reading. Over time, you should be able to obtain a clearer picture of what dose will help you achieve low blood pressure.

Park noted that, “If CBD works for you, without the use of other medications, I would say it is a great and safe alternative.” CBD may not be a replacement for exercise and a healthy diet, but it is nice to know you might be able to lower your blood pressure with a few drops of oil under the tongue.

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CBD oil seems to be a cure-all for many ailments, but does it lower high blood pressure? Here’s what research says about CBD and hypertension.

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Here’s How Long It Takes to Feel the Effects of CBD

Plus the preferred method for feeling it fastest.

CBD oil is the top trendy ingredient on the market right now. It’s so popular, in fact, that revenue from products made with CBD are projected to grow to $20 billion by 2024.

In case you’re wondering what is CBD, exactly?, here’s a quick refresher: CBD is a naturally occurring compound present in the flowers and leaves of cannabis plants. There’s no THC in it, which means it can’t get you high, no matter how much you take.

The reason CBD is so compelling to consumers is due to a laundry list of promising purported health benefits, from reduced muscle pain and anxiety to help with nausea, insomnia, and inflammation. We’re still waiting for clearance from the FDA (and more robust research on the proven perks of the ingredient), but in the meantime, many Americans are eager to test out the positive potential of CBD.

If you’re wondering whether it’s time to jump on the CBD bandwagon, you’re not alone. But as with any new food, drink, or supplement that promises health benefits, it’s best to start slow—and smart.

One question we often hear regarding trying CBD for the first time is how long it will take to have an effect on your body. According to Boris Shcharansky, the chief operating officer at Papa & Barkley, the length of time depends largely on the dosing method. Here’s a simple breakdown.

Topical forms of CBD

CBD topical products, like balm, ointments, and lotions, should take effect pretty immediately. Once you apply these products to your body, you should start feeling relief within about 15 minutes.

Ingestible forms of CBD

For ingestible products, like tinctures, capsules, gummies, and the like, the results are different. When kept under the tongue, tinctures typically absorb within 30 seconds and effects are felt within 15 minutes. When ingesting CBD (i.e., swallowing it or consuming a food that contains CBD), you can expect to feel the effects within about 45 minutes to two hours.

Don’t overdo it without waiting

If you’ve got aches, inflammation, or other issues that you’re hoping to soothe with CBD stat, be very careful not to overdose without waiting the appropriate period of time. “Ingesting CBD is typically associated with more attentiveness, less anxiety, and less inflammatory-related pain,” explains Shcharansky. “While higher doses—over 200 milligrams—have been associated with drowsiness.”

In other words, dosing should be determined on an individual basis, and consumers should be wary of high doses early on. If you’re curious what the right dosage of CBD is for you, read our guide here.

For those who are hoping to feel the effects of CBD as quickly as possible, Shcharansky recommends taking a tincture sublingually, meaning dropping it under your tongue, waiting a few seconds, and then swallowing.

“But the benefits of CBD are less about immediate effects and more about cumulative benefits,” he explains. “If you take CBD daily, you’ll continuously reduce your inflammation, which over time, should reduce your pain and keeps flare-ups at bay.”

If you’re wondering if it’s time to jump on the CBD bandwagon, you’re not alone. One question we often hear regarding trying CBD oil for the first time is how long it will take to feel CBD oil effects. Here’s a simple breakdown.

How long does it take CBD to work?

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Contents

  1. How does CBD interact with the body?
  2. The method of consumption matters
  3. Dosage matters
  4. How long does it take CBD to get out of your system?

So, you’ve heard about cannabidiol (CBD) oil possibly working wonders for chronic pain relief, anxiety, and many other conditions. You finally sit down, unscrew the cap from the CBD oil bottle, and prepare to set out on a soothing journey guided by this non-intoxicating cannabinoid. After taking a few drops of CBD oil or applying a CBD-infused topical to the skin, you might start to ponder the following questions:

  • How long does it take for CBD to work?
  • How long will the effects of CBD oil last?

More clinical research is required to answer these questions with unwavering confidence, but we can still look at how CBD interacts with the body to come up with well-educated estimates.

How does CBD interact with the body?

CBD interacts with the brain and body through a number of different mechanisms, creating a complex relationship that still merits further research before we can fully understand how this cannabinoid might relieve certain ailments.

Upon entering the system CBD interacts with a wide range of proteins in the body and central nervous system. A key part of this interaction takes place within the endocannabinoid system (ECS), specifically the CB1 and CB2 cannabinoid receptors. Unlike THC, which is the intoxicating cannabinoid that binds to these receptors and creates the stoned effect, CBD actually has an inverse effect. When cannabidiol is introduced to the ECS, it inhibits the absorption of anandamide, a natural cannabinoid that regulates pain.

When cannabidiol is introduced to the endocannabinoid system, it inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain. Photo by: Gina Coleman/Weedmaps

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CBD also interacts with other receptor proteins not directly related to the ECS, such as the serotonin receptor 5-HT1A and vanilloid receptor TRPV1. The widely perceived anti-inflammatory and pain relieving properties of CBD could stem from the activation of these additional biological pathways.

The relationship between CBD and the human body is rather complicated, but it’s a bit easier to understand how this cannabinoid moves through the body, as well as how long it takes CBD to leave your system. Even this answer, however, is contingent on several factors, including the method of consumption, the quality of the CBD product, and the person consuming CBD.

The method of consumption matters

Method of consumption plays a critical role in how long it will take to feel the effects of CBD. CBD is available in many different forms, and each has an influence on the onset time, among other factors.

Ingestion

The most common method for CBD consumption involves administering a couple of drops directly into the mouth. It is the quickest and easiest way to reap the potential benefits of this cannabinoid. But quickly swallowing the oil also prevents CBD from immediately entering the bloodstream, sending it instead through the digestive tract and eventually on to the liver, where it is broken down before finally reaching the bloodstream.

Studies show that when CBD compounds are metabolized by the liver, it undergoes what is called the “first pass effect,” where enzymes in the liver reduce CBD concentration before the remainder is finally sent to the bloodstream to be circulated throughout the body.

CBD oil dropper

Administering a couple of drops of CBD oil directly into the mouth is the quickest and easiest way to reap the benefits Photo by: Gina Coleman/Weedmaps

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CBD oil dropper

For ingestion of CBD edibles, the same principle applies. Let’s say, for example, you’re taking CBD gummies or adding a few drops of CBD oil into your favorite recipe. It will ultimately go through the same lengthy process and reduce the total CBD concentration found in your blood stream. With ingestion, it could be one to two hours before the effects of CBD finally set in.

Sublingual

CBD oil can be consumed sublingually by placing a few drops of CBD under the tongue before swallowing. By using this method, CBD is absorbed by the mucous membranes located in the mouth, bypassing the digestive system and liver. Compared with ingestion, this process allows the consumer to skip over the initial metabolization process, where CBD molecules are broken down in the liver, allowing it to enter the bloodstream more quickly.

Inhalation

Whether you’re smoking a high-CBD strain or taking a draw from a CBD vape pen, inhalation is often seen as an effective method of delivery for CBD because of how quickly it’s absorbed in the body. When CBD is smoked or vaped, cannabinoids are sent directly to the lungs, where they are rapidly absorbed into the bloodstream and put into circulation throughout the body. It reaches peak concentrations within three minutes after consumption, meaning the effects can be felt shortly after use.

Topical

Topical CBD is applied directly to the skin and can be absorbed through the surface of the skin to interact with localized cannabinoid receptors. In some cases, CBD-infused topicals should be applied liberally to overcome the low cannabinoid absorption rate of the skin. When CBD is applied topically, the effect peaks at about 90 minutes. This method of administration is often used for chronic pain in specific areas.

Topical CBD is applied directly to and can be absorbed through the surface of the skin. Photo by: Gina Coleman/Weedmaps

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Dosage matters

The way CBD operates throughout the body – and is inevitably excreted from the body – also depends on several factors that vary from person to person.

Body weight

The amount of body fat influences the amount of CBD needed to be effective. Someone with a larger body mass will require more CBD in order to feel the effects. Body weight and mass also affect how long CBD remains in the system. Like THC, CBD is stored in fat cells and gradually eliminated from the body through urine and feces. Does CBD have to build up in your system to work effectively? No, but it does get stored in the fat cells and can remain in the body well after the effects of CBD diminish.

Metabolism

The metabolic rate of the individual also has some sway over how long CBD stays in the system. The body’s metabolism determines how long it takes to break down and synthesize compounds, which affects how long it takes the body to process and metabolize the cannabinoid.

The body’s metabolism affects how long it takes to process and metabolize cannabinoids. Photo by: Gina Coleman/Weedmaps

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Frequency of use

It’s not just the human body that influences how long it takes CBD to work, but also the quality of the CBD product and how often it’s used. Once the CBD oil is acquired, the next step is to find the optimal dosing regimen, including frequency of use. Perhaps you’ve wondered to yourself:

  • Should I take CBD oil in the morning or at night?
  • What’s the right time of day to take CBD?

The answers will depend largely on the type of product, amount of CBD inside it, and the specific ailment you are targeting. Most reputable manufacturers will provide instructions on how to properly utilize the product, but experimentation may be required to find the optimal dose for you and your specific needs.

CBD dosage

Settling on the ideal CBD dosage is an important part of the treatment process, and will also impact how long CBD stays in your system.

Hemp-derived CBD products are not intended to give the user a stoned buzz or intoxicated feeling, so there’s no need to be conservative with the dosage amount. Still, it’s recommended to start with a lower dosage and gradually increase it until the ideal effects are discovered.

How long does it take CBD to get out of your system?

We’ve covered the factors that determine how long it takes for CBD to work, but what about how long it takes to get CBD out of your system? Again, it depends on many of the aforementioned factors that determine the effectiveness of the cannabinoid itself.

A 2007 study states that CBD can be detected up to 72 hours after smoking. Since the effects of CBD may be felt directly after inhalation, this method is appealing for those seeking immediate pain relief. In another study, volunteers were given soft-gelatin capsules of cannabis extract containing 2.5 milligrams of THC and 1.35 milligrams of CBD. The research team found that CBD was only detectable in the blood for up to six hours after ingestion.

woman smoking joint

CBD can be detected up to 72 hours after smoking. Photo by: Gina Coleman/Weedmaps

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woman smoking joint

Some people may be apprehensive to try CBD over concerns that it could cause them to fail a drug test. It’s highly unlikely that CBD would show up on most drug screenings, as most tests specifically look for the presence of THC and THC metabolites. But even hemp-derived CBD can contain trace amounts of THC, so there’s technically a chance, albeit extremely slim, of receiving a false positive test result from taking an unusually large dose (estimates range from 1,000 to 2,000 milligrams per day) of CBD oil.

For those worried about THC showing up in their system, look for broad-spectrum oil or products that contain pure CBD isolate. Broad-spectrum oil, as opposed to full spectrum oil, is refined to exclude the trace amounts of THC that may have been present in the hemp plant. Products with CBD isolate contain no THC or other plant-based cannabinoids. To find high-quality CBD, search for products that come with a certificate of analysis from a third-party testing lab to ensure that the information listed on the product label is accurate. Also, be on the lookout for products that claim to be hemp seed oil or hemp oil, which seldom contains any CBD at all.

How long does it take CBD to work? Copy article link to clipboard. Link copied to clipboard. Contents How does CBD interact with the body? The method of consumption matters

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U.S. Food and Drug Administration

FDA News Release

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The U.S. Food and Drug Administration today approved Epidiolex (cannabidiol) [CBD] oral solution for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients two years of age and older. This is the first FDA-approved drug that contains a purified drug substance derived from marijuana. It is also the first FDA approval of a drug for the treatment of patients with Dravet syndrome.

CBD is a chemical component of the Cannabis sativa plant, more commonly known as marijuana. However, CBD does not cause intoxication or euphoria (the “high”) that comes from tetrahydrocannabinol (THC).

It is THC (and not CBD) that is the primary psychoactive component of marijuana.

“This approval serves as a reminder that advancing sound development programs that properly evaluate active ingredients contained in marijuana can lead to important medical therapies. And, the FDA is committed to this kind of careful scientific research and drug development,” said FDA Commissioner Scott Gottlieb, M.D. “Controlled clinical trials testing the safety and efficacy of a drug, along with careful review through the FDA’s drug approval process, is the most appropriate way to bring marijuana-derived treatments to patients. Because of the adequate and well-controlled clinical studies that supported this approval, prescribers can have confidence in the drug’s uniform strength and consistent delivery that support appropriate dosing needed for treating patients with these complex and serious epilepsy syndromes. We’ll continue to support rigorous scientific research on the potential medical uses of marijuana-derived products and work with product developers who are interested in bringing patients safe and effective, high quality products. But, at the same time, we are prepared to take action when we see the illegal marketing of CBD-containing products with serious, unproven medical claims. Marketing unapproved products, with uncertain dosages and formulations can keep patients from accessing appropriate, recognized therapies to treat serious and even fatal diseases.”

Dravet syndrome is a rare genetic condition that appears during the first year of life with frequent fever-related seizures (febrile seizures). Later, other types of seizures typically arise, including myoclonic seizures (involuntary muscle spasms). Additionally, status epilepticus, a potentially life-threatening state of continuous seizure activity requiring emergency medical care, may occur. Children with Dravet syndrome typically experience poor development of language and motor skills, hyperactivity and difficulty relating to others.

Lennox-Gastaut syndrome begins in childhood. It is characterized by multiple types of seizures. People with Lennox-Gastaut syndrome begin having frequent seizures in early childhood, usually between ages 3 and 5. More than three-quarters of affected individuals have tonic seizures, which cause the muscles to contract uncontrollably. Almost all children with Lennox-Gastaut syndrome develop learning problems and intellectual disability. Many also have delayed development of motor skills such as sitting and crawling. Most people with Lennox-Gastaut syndrome require help with usual activities of daily living.

“The difficult-to-control seizures that patients with Dravet syndrome and Lennox-Gastaut syndrome experience have a profound impact on these patients’ quality of life,” said Billy Dunn, M.D., director of the Division of Neurology Products in the FDA’s Center for Drug Evaluation and Research. “In addition to another important treatment option for Lennox-Gastaut patients, this first-ever approval of a drug specifically for Dravet patients will provide a significant and needed improvement in the therapeutic approach to caring for people with this condition.”

Epidiolex’s effectiveness was studied in three randomized, double-blind, placebo-controlled clinical trials involving 516 patients with either Lennox-Gastaut syndrome or Dravet syndrome. Epidiolex, taken along with other medications, was shown to be effective in reducing the frequency of seizures when compared with placebo.

The most common side effects that occurred in Epidiolex-treated patients in the clinical trials were: sleepiness, sedation and lethargy; elevated liver enzymes; decreased appetite; diarrhea; rash; fatigue, malaise and weakness; insomnia, sleep disorder and poor quality sleep; and infections.

Epidiolex must be dispensed with a patient Medication Guide that describes important information about the drug’s uses and risks. As is true for all drugs that treat epilepsy, the most serious risks include thoughts about suicide, attempts to commit suicide, feelings of agitation, new or worsening depression, aggression and panic attacks. Epidiolex also caused liver injury, generally mild, but raising the possibility of rare, but more severe injury. More severe liver injury can cause nausea, vomiting, abdominal pain, fatigue, anorexia, jaundice and/or dark urine.

Under the Controlled Substances Act (CSA), CBD is currently a Schedule I substance because it is a chemical component of the cannabis plant. In support of this application, the company conducted nonclinical and clinical studies to assess the abuse potential of CBD.

The FDA prepares and transmits, through the U.S. Department of Health and Human Services, a medical and scientific analysis of substances subject to scheduling, like CBD, and provides recommendations to the Drug Enforcement Administration (DEA) regarding controls under the CSA. DEA is required to make a scheduling determination.

The FDA granted Priority Review designation for this application. Fast-Track designation was granted for Dravet syndrome. Orphan Drug designation was granted for both the Dravet syndrome and Lennox-Gastaut syndrome indications.

The FDA granted approval of Epidiolex to GW Research Ltd.

FDA approved Epidiolex (cannabidiol) oral solution, the first drug comprised of an active ingredient derived from marijuana, to treat two rare and severe forms of epilepsy.

Cannabidiol oral solution

Epidiolex ® (EH-peh_DYE-oh-lex) oral solution CV is the brand name for the cannabidiol oral solution, also referred to as CBD, from Greenwich Biosciences. The name or look may be different in other countries, but the dose (measured in milligrams, abbreviation “mg”) usually will be the same. Epidiolex is a quality grade of cannabidiol oil that is different from CBD or cannabidiol that is not U.S. Food and Drug Administration (FDA) approved.

Epidiolex is Approved for Use:

In people age 2 years and older for seizures associated with Lennox-Gastaut Syndrome and Dravet Syndrome.

Forms

Cannabidiol oral solution is availabe as 100 mg in each milliliter (abbreviated as “mL”).

  • Each bottle contains 100 mL of a clear colorless to yellow solution with a strawberry flavor.
  • Two 5 mL syringes will come with each bottle of medicine. These can be reused.
  • A 1 mL syringe is available from the pharmacist when smaller doses are needed.

Dosing

Blood tests for liver function, called serum transaminases (ALT and AST) and total bilirubin levels should be done in each person before starting Epidiolex.

The dose in children is based on weight, written as milligrams per kilograms or “mg per kg”. It is important to follow the instructions given by the prescribing health care provider.

  • The recommended starting dose is 2.5 mg per kg taken twice a day. (Total daily dose would be 5 mg per kg).
  • Your provider may recommend increasing the dose after 1 week to 5 mg per kg twice a day. (Total daily dose would be 10 mg per kg).
  • Epidiolex can be increased higher if needed to 10 mg per kg twice a day. (Total daily dose would be 20 mg per kg).
  • The dose may be different or changed for people with liver problems.

How To Take:

Take Epidiolex exactly as your health care provider prescribes it. Do not change your dose without talking to your provider first. Stopping a seizure medicine suddenly can cause seizures that will not stop (status epilepticus).

  • Take the medicine twice a day by mouth.
  • Check the amount and concentration of the oral solution from the pharmacy.
  • A special measuring device (called a syringe) will come with each prescription bottle. Use this syringe to measure the exact dose of medicine. Do not use a regular teaspoon to measure the medicine.
  • Use a dry syringe each time you measure a dose of Epidiolex. Water inside the syringe could make the oil-based medicine look cloudy.
  • Take the medicine about the same time each day with or without food. Certain foods can increase the amount of Epidiolex that is absorbed in your body, so take it the same way each day.
  • Take only the amount that your provider tells you to take.
  • If you take an extra dose, call your provider for advice.
  • If you take a larger amount of the liquid, call the poison control center (800-222-1222) or call your hospital emergency department for instructions.
  • When Epidiolex is stopped, the dose should be lowered slowly. Your provider will give you specific instructions on how to do this.

How To Store:

  • Store Epidiolex in its original bottle in an upright position at 68°F to 77°F.
  • Do not refrigerate or freeze the medicine.
  • Keep the child proof cap closed tightly.
  • Use the medicine within 12 weeks of first opening the bottle. Throw away any unused medicine after 12 weeks.
  • Keep Epidiolex out of reach of children.

Taking the right amount of seizure medicine, on time every day, is the most important way to control seizures.

  • If you miss a dose, take it as soon as you remember it.
  • If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
  • Avoid taking 2 doses at the same time or taking extra doses.
  • If you are not sure about what to do, call your provider’s office for advice and follow their directions.
  • To avoid missed doses, set an alarm on your watch, phone or other digital device.
  • Use an online seizure diary or text message system (Texting 4 Control) to send you reminders of when to take medicines.
  • Write down any missed doses in your seizure diary. Share this with your health care provider at each visit.

There are different ways that medicines can affect the brain to stop seizures. In general, seizure medicines make the brain less likely to have seizures by lowering the excitability of brain cells that cause seizures.

  • The exact way that Epidiolex works to control seizures is unknown. Scientists believe Epidiolex works in more than one way.
  • Epidiolex may inhibit or slow down the way messages or signals are sent in the brain. It may change calcium levels in brain cells that are important for sending messages or signals between cells. The medicine may also decrease inflammation in the brain.
  • Researchers continue to study how cannabidiol works to help stop seizures.
  • After a medicine is swallowed, it is absorbed into the bloodstream and travels through the body and to the brain.
  • The way the body metabolizes or breaks down a medicine affects how often it must be taken.
  • Epidiolex is broken down primarily in the liver and the gut. It is cleared from the body through the feces and in a small amount through urine.

Epidiolex has been tested in people with Lennox-Gastaut (LGS) and Dravet Syndrome (DS).

  • In controlled trials in people with LGS (age 2 to 55 years), the number of drop seizures (atonic, tonic, or tonic-clonic seizures) decreased significantly from baseline for people taking 10 mg per kg per day and 20 mg per kg per day. Improvements were also seen in non-drop seizures.
  • In trials of 120 people with DS (age 2 to 18 years), the average (median) decrease in number of convulsive seizures was significantly greater for people taking 20 mg per kg per day (39% decrease) than for people taking placebo (13% decrease).

Call your health care provider if side effects occur that bother you. These may go away on their own or the dose of medicine may need to be changed. Sometimes side effects mean that you don’t tolerate the medicine and the medicine may need to be stopped. Don’t stop taking any medicine suddenly on your own.

  • Sleepiness
  • Decreased appetite
  • Diarrhea
  • Increase in liver enzymes
  • Rash
  • Sleep problems
  • Infections

Since Epidiolex may make some people sleepy, do not drive, use heavy equipment or do other dangerous activities until you know how Epidiolex affects you. People who are not seizure free also may not drive due to legal restrictions. Talk to your doctor about your seizure control, medicines, and ability to drive.

Serious side effects of Epidiolex are rare. It is important to be aware of possible reactions and what to do if they happen. Only a very small number of people have died from them.

  • Read the package insert for a complete list of all reactions to Epidiolex.
  • Call your provider’s office right away if any of these problems occur.

Allergic or hypersensitivity reactions: Tell your provider if you develop any redness, itching, rash, or swelling after starting Epidiolex. These may need treatment or the drug may be stopped.

  • Epidiolex should not be given to anyone with a prior reaction or sensitivity to cannabidiol or any of the other ingredients in the product. Sesame seed oil is present in Epidiolex.

Liver problems: Increases in liver function can be seen on blood tests in some people taking Epidiolex, especially people who may also be taking valproate (also called valproic acid or sodium valproate). It has also been seen in people taking clobazam with Epidiolex.

  • Increases in the liver function tests were usually seen in the first two months of starting the drug. The changes can be seen months later however, especially if a person also takes valproate.
  • In 1 out of 3 people the blood tests returned to normal without any changes in medicine. In other people, the problems went away when Epidiolex was stopped or the dose of valproate or Epidiolex was lowered.

Monitoring for liver function: Blood tests for liver function should be done before starting Epidiolex and after taking it for 1, 3 and 6 months. Talk to your health care provider about when to have these done.

Some symptoms of liver problems may include:

  • Black or pale color of bowel movements
  • Loss of appetite
  • Nausea, upset stomach, vomiting
  • Stomach pain
  • Tired
  • Yellow eyes or skin
  • Dark urine

Tell your health care provider right away if you notice any of these problems. Do not stop taking Epidiolex or any seizure medicine without your doctor’s advice.

Somnolence and Sedation: Some people taking Epidiolex may be unusually tired, sleepy or sedated. In controlled trials, these symptoms were seen in 1 out of 3 people taking the drug compared to 1 out of 10 people taking a placebo (inactive pill).

  • Sleepiness and sedation happened more often in people also taking clobazam (Onfi).
  • The symptoms were seen early when the medicine was started and tended to improve over time.
  • Other medicines that cause sedation or sleepiness or using alcohol could make this worse in people taking Epidiolex.
  • Talk to your health care provider if sleepiness happens and if you are taking clobazam (Onfi) or other substances that cause sleepiness.

Suicidal thoughts and behavior: In 2008, the Food and Drug Administration (FDA) reviewed data from drug studies that showed a possible relationship between many seizure medicines and suicidal thoughts and behavior. Together, these thoughts and behavior are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, more had symptoms of suicidality than people taking a placebo or inactive substance – 3.5 of 1,000 people taking a seizure medicine had suicidality compared to 1 of 1,000 people taking a placebo.

  • Taking seizure medicines may increase the risk of having suicidal thoughts or actions.
  • Do not make any changes to the medicines without first talking to your prescribing health care provider.
  • Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.
  • Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:
    • Talking or thinking about wanting to hurt yourself or end your life
    • Withdrawing from friends and family
    • Becoming depressed or having your depression get worse
    • Becoming preoccupied with death and dying
    • Giving away prized possessions
  • Contact your health care provider before stopping any seizure medicine. This could possibly lead to worsening of seizure and mood.

Withdrawal of seizure medicines: Epidiolex, just like any seizure medicine, should be withdrawn slowly when it is being stopped. Stopping Epidiolex or any seizure medicine suddenly can lead to more seizures and life-threatening status epilepticus.

  • If Epidiolex needs to be stopped quicker due to another problem, follow your doctor’s advice on how to make changes.

Some people taking Epidiolex and valproic acid or valproate (Depakene or Depakote) or clobazam (Onfi) have had an increase in liver enzymes.

  • Liver tests need to be checked and the dose of one of these medicines may need to be changed. Some people may not be able to take Epidiolex if this happens.

Epidiolex appears to affect a byproduct or metabolite of clobazam (Onfi). This may increase side effects of clobazam, such as excessive sleepiness or sedation.

  • Talk to your provider if taking clobazam and Epidiolex together and watch for changes in side effects. The dose of one or both of the medicines may need to be changed.

Using alcohol and other products that depress the central nervous system or brain activity (CNS depressants) while taking Epidiolex can increase sleepiness or sedation.

Epidiolex could affect some other medicines that are broken down or metabolized by the liver.

  • Tell your health care provider and pharmacist all the prescription and over the counter medicines that you take.
  • Report any changes in symptoms or side effects to your health care team.

Do not take Epidiolex if you are allergic or have a history of reactions to cannabidiol or any of the ingredients in this medicine (such as dehydrated alcohol, sesame seed oil, strawberry flavor, sucralose).

Do not use Epidiolex for other reasons or if not prescribed by a licensed health care provider.

Do not give Epidiolex to other people, even if they have similar symptoms.

  • Epidiolex has been studied in children 2 years of age and older for safety and how well it works to control seizures. The safety and effectiveness in children under 2 years old is not known.
  • The dose of Epidiolex that is prescribed is based on a person’s weight. Tell your health care providers if weight changes as the dose of medicine may need to be adjusted.

Taking medication during pregnancy is a common concern for women. Most medicines carry some risk, but the extent of risk is often unknown.

Effects of Epidiolex during pregnancy: There are no adequate data on the developmental risks of Epidiolex on a baby when taken by a woman during pregnancy. Based on research in animals, Epidiolex may cause harm to a baby when the mother uses this medicine during pregnancy.

  • All women who take seizure medicines and are able to become pregnant should take at least 0.4 mg (400 mcg) of folic acid or folate daily to help prevent birth defects (such as neural tube defects) in a child.
  • Women at high risk of having a child with a birth defect (such as those with a history of a birth defect in a prior pregnancy or taking certain seizure medicines) may be asked to take a higher dose, for example 4 mg (4,000 mcg) of folic acid daily before and during pregnancy.
  • Talk to your doctor about other possible risks to your unborn child. Ask about the risks of using the medicine during pregnancy and the risks of seizures.

Seizures during pregnancy: Some women may have more seizures during pregnancy, because of hormone changes and how seizure medicine is handled by your body. Blood levels of seizure medicine may need to be checked more regularly during pregnancy so the dose can be adjusted if needed.

Women who are pregnant or are thinking of becoming pregnant, should consider contacting the North American Antiepileptic Drug (NAAED) Pregnancy Registry at 1-888-233-2334 or visiting www.aedpregnancyregistry.org. This and other registries monitor pregnancy outcomes in women taking seizure medicines during pregnancy.

Breastfeeding: There is no information about Epidiolex or its breakdown products being present in breastmilk or the effects on milk production. With most seizure medicines, the amount of medicine the baby is exposed to while breastfeeding is less than during pregnancy. If you want to breastfeed your baby, check with your health care team about the best approach.

Contraception: There is no information about the use of Epidiolex when a woman is taking a hormonal form of birth control. Some other seizure medicines can make certain forms of birth control less effective.

  • Tell your health care team and pharmacist if you are taking hormonal birth control such as the pill, injection, or patch.
  • Ask what form of birth control would be best if you are also taking Epidiolex.

Epidiolex has not been tested in older adults, thus the use of this medicine in seniors is unknown.

  • Older adults may be more sensitive than younger adults to medicines and their side effects.
  • Other medical problems (such as changes in liver or kidney function) may affect the dose of medicine prescribed.
  • Older adults may also be on other medicines that can interact with each other and cause more side effects.
  • In general, lower doses of seizure medicines are given to older adults and the dose is increased more slowly.

Epidiolex and Drug Testing

People who take Epidiolex may test positive for cannabis drug screens. Tell the person giving the drug test that you are taking Epidiolex for a medical reason.

In the United States, companies that manufacture medicines are required to publish a “package insert.” This document gives detailed information about the medicine and what you should know if you are taking it.

Cannabidiol oral solution Epidiolex ® (EH-peh_DYE-oh-lex) oral solution CV is the brand name for the cannabidiol oral solution, also referred to as CBD, from Greenwich Biosciences. The name or

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In This Section

Contact Us

Office of Drug & Alcohol Policy & Compliance

1200 New Jersey Ave, SE
Washington , DC 20590
United States

Email: [email protected]
Phone: 202-366-3784
Alt Phone: 800-225-3784
Fax: 202-366-3897

DOT “CBD” Notice

DOT OFFICE OF DRUG AND ALCOHOL POLICY AND COMPLIANCE NOTICE

The Agricultural Improvement Act of 2018, Pub. L. 115-334, (Farm Bill) removed hemp from the definition of marijuana under the Controlled Substances Act. Under the Farm Bill, hemp-derived products containing a concentration of up to 0.3% tetrahydrocannabinol (THC) are not controlled substances. THC is the primary psychoactive component of marijuana. Any product, including “Cannabidiol” (CBD) products, with a concentration of more than 0.3% THC remains classified as marijuana, a Schedule I drug under the Controlled Substances Act.

We have had inquiries about whether the Department of Transportation-regulated safety-sensitive employees can use CBD products. Safety-sensitive employees who are subject to drug testing specified under 49 CFR part 40 (Part 40) include: pilots, school bus drivers, truck drivers, train engineers, transit vehicle operators, aircraft maintenance personnel, fire-armed transit security personnel, ship captains, and pipeline emergency response personnel, among others.

It is important for all employers and safety-sensitive employees to know:

  1. The Department of Transportation requires testing for marijuana and not CBD.
  2. The labeling of many CBD products may be misleading because the products could contain higher levels of THC than what the product label states. The Food and Drug Administration (FDA) does not currently certify the levels of THC in CBD products, so there is no Federal oversight to ensure that the labels are accurate. The FDA has cautioned the public that: “Consumers should beware purchasing and using any [CBD] products.” The FDA has stated: “It is currently illegal to market CBD by adding it to a food or labeling it as a dietary supplement.”* Also, the FDA has issued several warning letters to companies because their products contained more CBD than indicated on the product label. **[i]
  3. The Department of Transportation’s Drug and Alcohol Testing Regulation, Part 40, does not authorize the use of Schedule I drugs, including marijuana, for any reason. Furthermore, CBD use is not a legitimate medical explanation for a laboratory-confirmed marijuana positive result. Therefore, Medical Review Officers will verify a drug test confirmed at the appropriate cutoffs as positive, even if an employee claims they only used a CBD product.

It remains unacceptable for any safety-sensitive employee subject to the Department of Transportation’s drug testing regulations to use marijuana. Since the use of CBD products could lead to a positive drug test result, Department of Transportation-regulated safety-sensitive employees should exercise caution when considering whether to use CBD products.

The contents of this document do not have the force and effect of law and are not meant to bind the public in any way. This document is intended only to provide clarity to the public regarding existing requirements under the law or agency policies. This policy and compliance notice is not legally binding in its own right and will not be relied upon by the Department as a separate basis for affirmative enforcement action or other administrative penalty. Conformity with this policy and compliance notice is voluntary only and nonconformity will not affect rights and obligations under existing statutes and regulations. Safety-sensitive employees must continue to comply with the underlying regulatory requirements for drug testing, specified at 49 CFR part 40.

DOT OFFICE OF DRUG AND ALCOHOL POLICY AND COMPLIANCE NOTICE

Can Truck Drivers Use CBD Oil? A 2020 Guide

Written By: Armela Escalona

With all the madness surrounding COVID-19, truck drivers have stepped up in a big way for us. These heroic men and women have been driving around-the-clock to help us hold on to some normalcy during these uncertain times.

So in light of their perseverance and dedication, we wanted to take a moment to share our gratitude and answer questions that we’ve been getting from these patriotic road warriors, as well as expand on some additional topics.

To start, the use of cannabis for medical and recreational purposes is now legal in 11 U.S states . Cannabis-derived products, such as cannabidiol (CBD) oils, are now federally legal.

Surely you’ve seen several advertisements that market the product as add-ins for your favorite drinks (coffee or smoothie) or a great addition to your natural skincare routine.

And despite all its popularity, many people are still unsure about CBD and are concerned about its effects, including our 18-Wheelin’ friends. So, Can truck drivers use CBD oil? Is it safe to drive after using CBD oil? Is CBD legal?

Can Truck Drivers Use CBD Oil?

CBD oil is federally legal in the United States, so yes truck drivers, just like anyone else, can use CBD products. Keep in mind that the laws regarding CBD’s status have varying degrees of restrictions. Some states allow the full use of the product while others restrict it altogether. Not confusing at all, right?

If you are driving through multiple states, it’s a good idea to take a look at the restrictions for each one. Here’s a map to help you safely navigate cannabis law.

can truck driver use cbd oil? a 2020 US CBD legality map

There are a few states highlighted in purple which either restrict cannabis products or do not regulate them at all. The three states where it is not legal in any form are South Dakota, Idaho, and Iowa. Avoid these states if possible if you’re using CBD or low THC products.

In teal states like California and Colorado, all cannabis products are both medicinally and recreationally legal, so no issues there.

The states highlighted in yellow, like Florida and Arizona, have legalized medicinal cannabis and allow for over-the-counter CBD and low THC products.

And the states highlighted in orange, like Georgia and Tennessee, only allow CBD and low THC products.

So if you’re driving cross-country with CBD, the only three states you have to worry about are South Dakota, Idaho, and Iowa.

Can I use CBD while driving?

Generally speaking, CBD oil is safe to use throughout the day. Even if you purchase a full-spectrum CBD product that contains trace amounts of THC, it’s not going to have an intoxicating effect on you.

Some customers have reported a drowsy or sleepy side-effect from taking CBD, so if you have a similar experience, we do not recommend you operate a motorized vehicle. It’s always a good idea to speak with a physician to find a dose that works best for you before integrating it into your day-to-day.

What if I get pulled over with CBD?

You got pulled over and you have CBD? Don’t panic, remember, CBD is federally legal. Again, it’s a good idea to keep local and state regulations in mind when purchasing and consuming any product, but if you did your homework beforehand and it’s permissible where you’re driving, then you’re in the clear.

Regardless, any quality CBD brand will make their lab tests accessible on their website, and depending on the state, the product must be properly labeled and include a QR code linked to the lab tests for that specific batch. This is important because those 3rd party lab tests confirm that the product contains the legal amount of 0.3% or less in THC.

So if you’re ever in doubt, simply scan the QR code with your phone and keep the lab tests handy while.

cbd oil lab test

What’s in CBD Oil? — Why is there an ongoing debate about its legality?

Cannabidiol or CBD is a secondary compound found in the cannabis sativa plant. The primary compound—which is also the more famous one— is tetrahydrocannabinol or “THC”. This is the active ingredient that induces the psychoactive or euphoric effect of cannabis.

THC and CBD are just two of the more than 80 organic cannabinoids present in the plant. According to researchers, cannabinoids are the chemicals that protect the plant from UV rays. Cannabinoid levels also change with sun exposure . This is why the flowers from the female plant often have more cannabinoids than the rest of the plant.

THC and CBD only have slight differences when you look at their chemical structure. Despite this, they’re very different when it comes to their effects. While THC’s psychoactive effect helps with ailments like nausea, CBD is shown to aid in relieving inflammation, joint pain and aches, as well as mood and overall mental health. Experts are also studying CBD and its effects on children and teens with drug-resistant epilepsy.

What Are The Benefits of CBD Oil?

With excellent anti-inflammatory and antioxidant properties, CBD has been shown to offer some health benefits, both physical and mental. The most promising include studies that point to early clinical trial data showing CBD’s efficacy with regard to epilepsy and varying forms of seizures .

Marijuana users often claim they use the drug for its calming effects. This effect is also seen in CBD users and may include relief from neuropathic pain and anxiety, as well as cognitive symptoms associated with Alzheimer’s and Dementia .

CBD oil is also known for its benefits on the skin . Findings show that the fatty acids present in the oil can protect the skin from breakouts and inflammation whilst keeping the skin nourished and moisturized. It can also aid with various skin conditions such as dermatitis, lichen planus, acne rosacea, and eczema.

There are still no clear findings on the mental health benefits of CBD and THC. Early trials show some encouraging data but it’s still too early to tell if CBD and THC are effective in treating psychiatric disorders.

Some studies showed promise in CBD’s ability to aid those who suffer from social anxiety, insomnia, and post-traumatic stress disorder. But as always, we recommend you speak with your primary care physician before taking any products.

Is CBD Oil Safe?

CBD oil is generally safe but there are side effects and risks that you should consider. Side effects of cannabidiol can include irritability, fatigue, and nausea. Other rare side effects include gastrointestinal problems, appetite loss, and altered liver enzymes.

The product is advised against women who are trying to conceive, or are pregnant or currently breastfeeding because ingredients in the cannabidiol products may be harmful to infants or fetuses.

CBD is also not recommended for people who are immune-compromised as well as people with liver disease and people with Parkinson’s disease. Studies found that cannabidiol actually worsens tremors and muscle movements in people with this disease.

What You Need To Know

As of 2020, the general rule of thumb for CBD consumers is this: CBD products are illegal in South Dakota, Iowa, and Idaho, but legal in every other state.

If you’re a truck driver and currently working, it is safe to take CBD products but make sure to avoid the states listed above. Also, don’t drive and take CBD products if they make you drowsy.

Remember, if you get pulled over by a police officer, kindly show him the lab tests for the product and the receipt for the purchase. Again, it’s perfectly legal in most states to have CBD products with you.

And lastly, speak to a physician when deciding what product and dose is best for you and your specific needs. Stay safe out there!

As of 2020, the general rule of thumb for CBD consumers is this: CBD products are illegal in South Dakota, Iowa, and Idaho, but legal in every other state. If you're currently driving through multiple states, make sure to keep your purchase receipt and 3rd party lab tests handy. Continue reading for more details.

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CBD Oil in Honolulu, Hawaii

Honolulu, Hawaii

Curious about where to buy CBD oil in Honolulu? Look no further!

Our favorite CBD products can be purchased online for delivery to Honolulu, Hawaii:

What Is CBD?

As our awareness of the health benefits of cannabinoids grows, many people have become aware of CBD, but have questions about what it is and how it’s used. Firstly, CBD is non-psychoactive. Like THC, it is extracted from the cannabis plant and, like THC, has a variety of health benefits and recreational applications. But unlike THC, CBD is derived from the hemp plant (not the marijuana plant) and it is non-psychoactive. CBD does not produce a high, and is completely legal in all states. CBD oil can be vaped, ingested, or even applied topically, and produces a sensation of relaxation, making it extremely useful in the safe and natural relief of anxiety, insomnia, inflammation, pain, ADHD, epilepsy, and a number of other health conditions.
ity.

Hawaii does allow the tightly restricted use of marijuana for approved medical conditions, and Honolulu is home to two dispensaries. CBD, on the other hand, can be freely purchased at a number of CBD shops in Honolulu, including CBD stores in Ala Moana, Liliha – Kapalama, Kaka’ako and McCully – Moiliili. Buyers do not need a doctor’s approval or a medical marijuana card, and new users can be assisted by the CBD shop sales staff to select the right product for their needs.

CBD Shops in Honolulu

Buyers can find CBD stores in the Ala Moana, Liliha – Kapalama, Kaka’ako and McCully – Moiliili neighborhoods in Honolulu, but i’s also possible to purchase CBD from the comfort of home, as a large number of world-class and trusted online CBD stores ship CBD oil, tinctures, vape supplies, soft gels ands topically right to buyers doors. neighborhoods.

Best CBD Oil Shop in Liliha – Kapalama

Located near Nu’uano Stream, Mr. Hemp CBD (286 N School St Ste B Mr. Ink Plus Honolulu, HI 96817 Kalihi) can be found on the border of Liliha – Kapalama and Kalihi – Palama. Mr Hemp CBD claims to be the #1 supplier of CBD in Honolulu, and with their focused selection and expert staff, it’s likely quite true, and you’d be hard-pressed to find a more specialized store. Housed in the same storefront as Mr. Ink, a printer and toner ink supplier, Mr. Hemp CBD offers CBD from top brands like Pure Hemp Botanicals, Receptra, Green Roads, NuLeaf, iPuff, and Treatables. The staff is focused 100% on the sale of top quality CBD and has advanced expertise in recommending the right product to solve a variety of health and mood conditions and to produce specific effects. Delivery methods include CBD sprays, CBD oil tincture drops, CBD vape liquid, CBD balms, CBD mints, gummies and lollipops, CBD salves, CBD capsules, and even CBD dog treats.

Best CBD Oil Shop in Ala Moana

Located in Ala Moana, 710 Hawaii (1501 Makaloa St Honolulu, HI 96814) is convenient to residents of this neighborhood, and surrounding Waikiki and Kaka’ako. This tidy smoke shop stocks a range of artistic and standard glassware and accessories, along with a selection of natural CD products. Choice include organic edible CBD dried fruit rolls made with Hawaiian pineapple, coconut, strawberry and other fruit, CBD gummies, CBD vape liquid, CBD oil tinctures in various potencies, CBD dab wax, and CBD salves and lotions. There’s even CBD infused water and CBD soda in funky flavors like grape, melon, and Captain Crunch. The store carries established CBD brands like CBD Plus, Cannabinoid Creations, and local favorite, CBD Wellness Hawaii. The staff are friendly and knowledgable, and the store has earned a five-star Yelp rating, with customers giving props for selection and ease of shopping.

Best CBD Oil Shop in McCully – Moiliili

2Highguys (2570 S Beretania St Honolulu, HI 96826) is located close to the border of Mānoa, not far from the University of Hawaiʻi at Mānoa. As the name implies, this establishment is a classic head shop, complete with glassware, tobacco and smoke accessories, and novelty apparel. The store is known for its wide selection of fruity vape flavors mixed in-house, and for affordable prices, and shoppers report that 2Highguys has the best cheap CBD in Honolulu. CBD drip vape liquid is their most popular CBD product, and the store boasts an average of 4.5 stars on Yelp. This affordable CBD shop is open 7 days per week, and stays open until 9 pm most days.

Best CBD Oil Shop in Kaka’ako

Brahddahs Smoke Shop (232 Waimanu St Fl 2 Ste F Honolulu, HI 96814) is located in Kaka’ako on the border of Ala Moana. This friendly smoke and CBD shop specializes in wide selection and cheap prices, and customers award the store an impressive 5 star average on Yelp. Reviewers claim the store has the biggest CBD selection in the area, and there are certainly a lot of options in their inventory. Brahddahs Smoke Shop sells both sweet and savory CBD edibles, CBD syrups and honey, CBD vape cartridges, kids and vape liquids in various flavors, CBD capsules, CBD salves and balms, and CBD tinctures and sprays. The store stocks premium national brands like Green Roads, CBD Drip, Weetos, Hemp Bombs, Cloud N9ne, as well as local companies Hawaii Cannibus Care and CBD Wellness Hawaii.

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CBD Oil in Hawaii

CBD Oil in Honolulu, Hawaii Curious about where to buy CBD oil in Honolulu? Look no further! Our favorite CBD products can be purchased online for delivery to Honolulu, Hawaii: What

Best CBD Oil in Hawaii

The Best Places to Buy CBD in Hawaii

As one of the most popular health and wellness products on the market, CBD is appearing in stores across the country, and Hawaii is no exception, with dozens of places to buy CBD products in Honolulu, Kahului, and the Island of Hawaii. If you’d rather buy CBD online, plenty of wholesale retailers are available: save on affordable CBD products, complimentary delivery service, and an excellent selection of CBD oils, juices, edibles, tinctures, and other CBD products in multiple grades.

Our favorite CBD product can be purchased online for delivery to Hawaii:

For your convenience, we’ve compiled the best places to buy CBD in Hawaii below, but first let’s review CBD’s legal status and the medical science behind the product.

Is CBD Legal in Hawaii?


Hawaii legalized medical marijuana back in 2000 with State Bill 862 HD1. It has been amended twice since that time, but the medical use of cannabis and marijuana-derived products remains legal for those who have a qualifying condition and a prescription from their doctor. Something interesting about the laws in Hawaii is that they are one of the only states that allows medical marijuana patients from other states to have access to the drug while they’re in Hawaii. Due to these laws, anyone who has a qualifying medical condition can use marijuana-derived CBD in the state of Hawaii.

For those of you who do not have a qualifying condition or just use CBD for recreational reasons, don’t fret. The use of hemp-derived CBD is legal for medicinal and recreational use in the state of Hawaii. They enacted a hemp research program all the way back in 2014. This program regulates the cultivation of industrial hemp but not the processing of the plant or products that are made from it. As long as you are purchasing hemp-derived CBD that meets the federal guidelines outlined in the Farm Bill that passed in 2018, you’re free to consume CBD.

What Is CBD?

There are over 85 cannabinoids in the cannabis plant, but CBD is different from other cannabinoids through the fact that is is non-psychotroipic. This makes CBD a safe, uncontroversial, and health-promoting alternative to similar products.

In particular, CBD affects the endocannabinoid system, which controls day-to-day functions including mood, sleep, hormone regulation, appetite, and pain. Evidence of progress in any of those categories would be a major breakthrough, but research suggests we’re only beginning to understand CBD’s greatest health advantages: dozens of chronic medical issues—cardiovascular disease, epilepsy, general anxiety disorders, schizophrenia, Alzheimer’s disease, and ALS, among others—might be reduced, mitigated, or prevented via regular CBD usage.

The more we learn about CBD’s potential health benefits, the more we’ll learn how to use it to reduce risks for everything from insomnia to depression to cancer.

CBD Oil Shops in Honolulu

Honolulu is home to a dozen shops selling premium CBD products. Mr. Hemp CBD (286 N School St, Honolulu, HI 96817) is a 5 star-rated shop selling CBD capsules, spray, salves, gummies, vape cartridges, and CBD oils. All the store’s products are tested by thirty-party labs to guarantee quality, and they are a certified retailer for NuLeaf Naturals, Hemp Health CBD and Green Roads CBD Products. 2Higuys (2570 S Beretania St, Honolulu, HI 96826) is another nearby CBD shop, with personalized customer service, an extensive inventory, and excellent hours seven days a week. Right next door is Choke Smoke (2671 S King St, Honolulu, HI 96826). In addition to excellent CBD options, Choke Smoke carries premium e-liquids, Kratom, vaporizers, dab pens, glass pipes, water pipes, rigs, hookahs, and more. If you’re downtown, check out Natural Mystic (203 S King St, Honolulu, HI 96813) for affordable CBD, e-juice, and vape accessories; and if you’re in the direction of Diamond Head, you can’t go wrong with VOLCANO eCigs (449 Kapahulu Ave, Honolulu, HI 96815), the island’s most popular CBD shop, which offers a variety of CBD products and online promotions.

Other highly-rated shops selling CBD: Smokey’s (159 Kaiulani Ave, Honolulu, HI 96815), Brahddahs Smoke Shop (1232 Waimanu St, Honolulu, HI 96814), Aloha Green Apothecary (1314 S King St, Honolulu, HI 96814), and the always-popular Fly Hi Hawaii (590 Farrington Hwy, Kapolei, HI 96707). Smokeless Hawaii Enterprises (719 Kamehameha Hwy
Pearl City, HI 96782) holds a perfect rating, with high marks for a deep inventory of CBD products and helpful staff. Finally, Down to Earth Organic & Natural (98-129 Kaonohi St, Aiea, HI 96701) is a health market that sells high-quality CBD in the vitamin/supplement section.

CBD Oil Shops in Kahului

There are two CBD shops in Kahului. First, Still Smokin’ – Kahului (346 North Market St, Wailuku, HI 96793), open seven days a week. Here you’ll find high-quality CBD oil, vaporizers, water pipes, and much more. For those interested in spa options, Maui Hemp Spa (930 Waine’e St, Lahaina, HI 96761) offers premium hemp-derived CBD massages using products developed in Hawaii.

CBD Oils Shops on The Island of Hawaii

Established in 2015, Hale Hookah (60 Waianuenue Ave, Hilo, HI 96720) holds a 5-star rating, with an extensive inventory of CBD products, vape accessories, Shisha, and Dokha tobacco. Customers highlight the knowledgeable staff, friendly customer service, and highly affordable CBD prices.

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CBD in Honolulu

Best CBD Oil in Hawaii The Best Places to Buy CBD in Hawaii As one of the most popular health and wellness products on the market, CBD is appearing in stores across the country, and Hawaii is