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how to convert cbd oil into thc

Converting CBD to Delta-8-THC

Many cannabinoids can convert into each other—after all, cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), and cannabichromenic acid (CBCA) stem from the same origin, cannabigerolic acid (CBGA), “the mother of cannabinoids.”

Converting prominent cannabinoids that are relatively abundant in cannabis into more obscure, scarce, but valuable ones through synthesis—chemical or bio—is a viable “cheat” code to produce sufficient amounts of these rare cannabinoids in a time- and cost-efficient manner.

In that spirit, a group of scientists including Raphael Mechoulam came up with a way to convert CBD into delta-8-THC (Δ 8 -THC ) or delta-9-THC (Δ 9 -THC) through chemical synthesis. They patented their process (through 2022) with the United States as patent US20040143126A1. The patent provides a basic outline:

  • Mix a Lewis acid in an organic solvent
  • Add CBD
  • Reflux the mixture
  • Dilute with an organic solvent
  • Pour into cold water
  • Mix
  • Let the mixture separate into aqueous and organic phase
  • Remove organic phase (the phase with the Δ 8 -THC)
  • Elute Δ 8 -THC

To achieve conversion into Δ 8 -THC, they added 300 mg of CBD to dried p-toluenesulfonic acid (30 mg) in toluene (15 ml), under N2 atmosphere (inert and free of oxygen). This was refluxed for one hour (superior to other times tested, including 30 minutes and two hours). The p-toluenesulfonic acid served as the catalyst. That said, other Lewis acids may be used, such as boron trifluoride. The mixture was diluted with 20 ml of ether and poured into cold water.

“The upper layer was separated, washed with aqueous 5% NaHCO3 [sodium bicarbonate], then with water, dried over MgSO [magnesium sulfate] and evaporated.”

High-performance liquid chromatography (HPLC) revealed 86% purity of Δ 8 -THC. The scientists note N2 atmosphere “does not appear as necessary as during the conversion of CBD to Δ 9 -THC. Besides toluene, other solvents, like benzene, can be used,” but not with the same efficacy, at least according to their tests.

It may be simpler to convert Δ 9 -THC to Δ 8 -THC. BR Instruments advises a spinning band distillation system with 4% acidic alumina silicate mixed into crude cannabis oil, noting that this “catalyze[s] the rearrangement of the THC molecule from delta-9 to delta-8-THC.”

Converting CBD to Delta-8-THC Many cannabinoids can convert into each other—after all, cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), and cannabichromenic acid (CBCA) stem

Isomerization Of Cbd To Thc

MirrorZen

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

DemonTrich
MirrorZen
Graywolf

We isomerized using sulfuric acid, but haven’t continued to do so because most of the material that we work with is already high in THC and low in CBD, so not much gain.

We are actually growing strains specifically for the CBD that we use in topicals, or using CBD from Hemp.

kansabis
MirrorZen
Graywolf
kansabis
ZenChem

We isomerized using sulfuric acid, but haven’t continued to do so because most of the material that we work with is already high in THC and low in CBD, so not much gain.

We are actually growing strains specifically for the CBD that we use in topicals, or using CBD from Hemp.

ZenChem
CBNight

Out of curiosity, how would you then isolate thc from the Zinc Chloride solution?

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

therealAries

Cannabidiol to THC – simple
(Rated as: excellent)

Cannabidiol (CBD), the main cannabinoid constituent of fibre hemp has been converted (isomerized) to delta-9 and delta-8-tetrahydrocannabinol employing a variety of conditions.
Many of these procedures require chemicals that are hard to come by such as dichloromethane (DCM) and boron trifluoride etherate.
The following is a simple and fast procedure for the synthesis of delta-8- or delta-9-THC from CBD:

Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Work up:
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Can chromatograph on silica gel with 1 to 2% ether in petrol ether for purification.

CBD can also be converted into delta-9-THC with anhydrous ZnCl2 at 150° without solvent (perform reaction best in vacuum as product is sensitive to oxidation):

Heat 0.5g CBD with 0.09g anhydrous ZnCl2 under vacuum with stirring.
After 2 hours 40 to 50% delta-9-THC have formed.

CBD converted to THC. Thats not possible all conpounds are converted from CBGa Cannabigerolic Acid to either chemotypes (CBDa) or (THCa)

Bless up and keep on learnin’ the facts are always helpful in keeping misinformation far away

Everything I post is for educational purposes and for entertainment purposes as well I am obsessed with cannabis and want to learn as much as possible

I know this is old news for the chem heads, but I know it's still not being used by the large percentage. It will only get more popular. Isomerizing cbd to…