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The Only Way is Up: A Guide to Dosing CBD

Alphagreen Team

Table of Contents

What is CBD, and what does it do?

The endocannabinoid system’s role

Dosing CBD: the basics

Scouting out the right CBD company & products

Factors in dosing

What are the different ways to take CBD?

When do the effects begin? And how long do they last?

How does CBD interact with the endocrine system?

Can I mix different CBD products?

Not feeling any different? Here’s why

Onwards and upwards

Summary

We will be letting you in on the precise factors that dictate dosages, such as your body weight, age, metabolism and consumption method. We will be educating anyone who needs to know how to source a reliable and trustworthy CBD brand and product, as well as all the ways you can take CBD and the advantages of each. What’s more, we have the answers to why your CBD may not be working for you.

Introduction

Need a hand when it comes to dosing cannabidiol? You have our sympathy — CBD doses can be exceptionally hard to get right. With a little guidance, you will be well on your way with knowing how to dose this otherwise marvellous cannabis constituent.

What is CBD, and what does it do?

CBD stands for cannabidiol. It is one of over 100 cannabinoids present in cannabis Sativa, a plant species consisting of two classifications — hemp and marijuana. We know, that’s a lot of information to receive in one sentence, so we’re going to dissect it further. A cannabinoid is a cannabis-derived compound. As we just said, CBD is one of many; there is also THC, CBC, CBG, CBN — you get the idea.

Of all those cannabinoids, our focus is on the second most abundant: CBD. “But why not focus on the most abundant?” you ask. Because the most abundant cannabinoid in cannabis is the infamous THC, which we will come to shortly.

CBD has become a hugely popular agent of wellness. Nowadays, you can find thousands of CBD-infused products, from topicals and patches you apply externally, to tinctures you administer under the tongue, and suppositories you insert down there. The CBD industry has shown that there are no limits when it comes to innovative consumption methods.

So what makes cannabidiol such a great wellness tool? The main reason for the growing popularity of the CBD is its seemingly endless therapeutic potential, paired with the fact that it is generally well-tolerated in the body. CBD has been known to have the potential to tackle chronic pain, manage our moods, relieve nausea, reduce symptoms of seizures and inflammation, enrich sleep, improve mobility and spasticity, and support many, many other aspects of our health. Cannabidiol has even been cited as a potential neuroprotector and has shown promise in bolstering quality of life among patients of Alzheimer’s disease, schizophrenia, and shows signs of performing antioxidant actions. The best part? CBD is non-addictive and non-psychotropic, so it will not make you high, regardless of the dose you take.

We appreciate that it all sounds too good to be true, but hear us out.

The endocannabinoid system’s role

The endocannabinoid system (ECS) is a cell-signalling biological network present in the bodies of basically all organisms. Its job is to maintain homoeostasis, or internal balance and harmony. Some of the functions it takes care of include our mood, appetite, sleep, cognitive performance, and so many others.

The system it’s made up of enzymes, endocannabinoids, and cannabinoid receptors. There are two types of cannabinoid receptors: CB1 receptors and CB2 receptors. These are found all over the body; CB1 receptors are mainly around the central nervous system, while CB2 receptors are usually concentrated around the immune system, particularly in the spleen. Endocannabinoids are the body’s own cannabinoids. When we take a cannabinoid like CBD, it is thought to interact with the components of the endocannabinoid system. It is believed to work with our CB1 receptors, controlling processes and functions to do with our mental health and stress responses, and with our CB2 receptors to control things like inflammation and pathogens — all things to do with immunity and immunoregulation. CBD does not bind itself to our receptors as THC does; rather, it supposedly influences the way our endocannabinoids bind to our CB1 and CB2 receptors.

In summary, the endocannabinoid system plays a crucial role in the effects we feel when we take CBD.

Dosing CBD: the basics

Calculating the right CBD dose may be a confusing prospect, especially for newbies to the world of CBD. Your unique dose is dependent on personal variables. Some examples of these variables are:

  • Physical health
  • Age
  • Weight
  • Height
  • Metabolism
  • Body mass index (BMI)
  • Health Conditions
  • CBD format (capsule, tincture, etc.).

It isn’t only pharmaceutical medications that are dangerous to take in excess; this applies to many organic or plant-derived products as well. True, the organic elements found in CBD products are completely natural, but that does not give you the green light to take cannabinoids as liberally as you like. There can be side effects, and certain doses can be incorrect for you. With this in mind, it is important to carefully consider dosage before you just begin your CBD intake.

Scouting out the right CBD company & products

Here are some handy tips for when you’re surfing the web for the right CBD company and products for you.

  • Find a reliable CBD Brand

The first and main goal is to choose a reliable CBD company. The product(s) you choose has several criteria to meet: it must meet the legal requirements for your country, it must be of an impressive quality and standard, it must meet certain safety standards, and not contain any undesirable chemicals or additives. Also important: it must be exactly what you want!

Here at Alphagreen, we only feature reliable products and brands on our platform. Every single CBD-infused product is lab-tested for contaminants, which you can see for yourself from their attached certificates.

  • Always check the ingredients

Before you reach checkout, it is important to read what is actually in the product(s) you’re buying. Ensure your product has a detailed description of all the substances it contains, as well as a clear indication of the CBD concentration. Your product should contain a good amount of CBD, as you don’t want to fall for one that is mostly made up of other ingredients and has a mere sprinkling of cannabidiol.

The quality of the CBD plays a crucial role in delivering effective results, so you must make sure to choose a high-quality product with high CBD content.

  • Always check the percentage

When we refer to CBD percentages, these numbers generally refer to the number of milligrams of CBD per product.

If we take a tincture that contains 2.5% CBD, this generally means it contains 250 milligrams of CBD. If this percentage is 4%, the concentration of CBD equates to 400 milligrams, and so on and so forth.

As the percentage of CBD increases, so too does its concentration.

In a 10 ml bottle of 2.5% CBD oil, the buyer will receive about 200 drops, and each drop will contain 1.25 mg of CBD.

If you take a daily dose of 3–4 drops three times a day, this means that you will consume approximately 15 mg of CBD daily.

Those who take a regular dose of CBD are far more likely to reap its wonderful potential benefits than those who do not make a regular habit out of their CBD consumption. For maximum possible benefits, determining the right dose is important; yet many consumers are still uninformed on how much CBD would best suit them and their needs.

It is important to remember that everybody’s endocannabinoid system is different, meaning the dosage can vary per person. Some will find that 3 mg twice a day is sufficient to obtain a calming and relaxing effect. Those with severe chronic pain, on the other hand, may take doses approaching 200 mg per day. This is not recommended unless under specific medical direction.

The best way to find the most suitable dose for you is to start with small doses and gradually increase. For newbies, daily doses of 5 mg may be enough to feel relief. After a few days or weeks, try increasing your dose to 10 mg and ensure you note the change in your response. Repeat this ritual as appropriate to find the optimal dose for you. Once you have established the desired dose, keep it consistent.

Those who have experience of using cannabis extracts may need to start with a higher dose as you may have a higher tolerance. You could begin with doses of 15–25 mg per day and increase (or not) as you feel is appropriate. It is advised that if you are a healthy adult, you do not surpass 70 mg per day.

Factors in dosing

Some of the individual factors that need to be taken into account are:

One of the important factors in finding your CBD dosage is your body weight. This is because each person has different levels of tolerance and different metabolisms.

A good idea is to use a maximum dose of 6 mg CBD for every 5 kg (10 lbs) of your body weight. However, if the answer to this formula in your case produces more than 70 mg, it is advised to keep to doses below this quantity.

Your health or condition

The state of your health also plays a vital role in discerning the right dose of CBD for you. You may be suffering from a health condition which affects you with various symptoms; you may suffer from chronic pain, or perhaps you struggle to sleep at night. You may be the picture of health. All of this is important when it comes to assessing the appropriate strength for your CBD dosage.

If you are taking mainstream pharmaceuticals for a health condition, it is important to contact your doctor before self-medicating with CBD. The reason for this is that CBD may interact with your medication(s), so it is crucial to ensure that the CBD is not disrupting their effectiveness. Your doctor or healthcare provider will be able to help you in that regard.

Medication(s) may dictate your CBD dosage; that is to say, you may be permitted to take both, so long as your CBD dose is below a certain amount, in order to achieve a fine balance in the body between the CBD and the medication. Your medication(s) may also dictate the time at which you take your CBD; they may need to be taken at opposite ends of the day, for example.

The concentration of your CBD

Naturally, if you buy a CBD oil that boasts a concentration of 1000mg CBD, you will require fewer drops per day than if you buy a CBD oil of 250 mg CBD .

Take a look at the table below to see roughly how much CBD is present in every drop, for all the different CBD concentrations. Note that this table only refers to CBD oil.

1.25 mg CBD per drop

2 mg CBD per drop

2.5 mg CBD per drop

5 mg CBD per drop

10 mg CBD per drop

What are the different ways to take CBD?

There are various products on the market containing CBD: vape oils for your vaporiser, sublingual oils and tinctures, topicals for your skin, edibles, transdermal patches, and so many more.

Of all these options, there is no one that is objectively the best. This depends on one’s preferences, the CBD concentration and the bioavailability. Bioavailability refers to the amount of a substance (CBD, in this scenario) that can be used by your body, which has not been lost on the way to the bloodstream. As far as bioavailability and potency are concerned, studies say that the two best methods on this score are sublingually-taken CBD and inhaled CBD.

Let’s review the various ways to consume CBD, and see how we might dose them.

CBD vape juices, oils & e-liquids

THC-free, nicotine-free CBD electronic liquids (e-liquids), vape oils or vape juices are used in vaporisers and electronic cigarettes (e-cigarettes). These CBD products are sold either in cartridges, liquid containers, or disposable vape pens, and, like regular e-liquids, they often come in different flavours.

What’s more, vaping CBD has one of the highest, if not the highest, bioavailability of any method. When you use a vaping device to inhale CBD via a vape oil or e-liquid, the bioavailability is so great because the digestive tract, with its powerful enzymes that degrade the potency of CBD, has no involvement. The other reason for its superior bioavailability is that the lungs have a thin lining, through which the CBD molecules seep directly into the bloodstream.

In terms of controlling and adjusting your CBD dose, vaping may not be the easiest way to do this, as it may be unclear how much CBD you’re taking in per draw. This could mean that vaping is the ideal delivery method for someone more experienced using CBD, who doesn’t necessarily need to think about their dose too rigidly.

To inhale CBD, all you need is one of these CBD e-liquids or vape oils as well as a vaporiser or an electronic cigarette.

CBD Sublingual Oils / CBD tinctures

Sublingual oils or tinctures are perhaps the most common method for consuming CBD. Why? They are highly commercialised products and marketed as the best way to take CBD. They are also often the foundational product of a company.

Depending on the format in which it is supplied, it can either be applied with a dropper/pipette or sprayed under the tongue.

Sublingual consumption is alongside vaping as the most bioavailable way of getting CBD into your system. This is another delivery method that retains the CBD’s potency and has a direct route to the bloodstream. Sublingual delivery involves dropping some CBD oil beneath the tongue and holding it there for up to 1 minute, allowing it to fully absorb into the sublingual gland. The bioavailability of sublingual consumption is 13–19%, though some have claimed it to be as high as 35%.

CBD oils will come in a carrier oil. Common examples of carrier oils are MCT coconut oil, olive oil, hemp seed oil, avocado oil, grapeseed oil, and pomegranate seed oil. A carrier oil that boasts its own health-supporting benefits is always preferable. Some companies then add flavourings to their CBD oils for consumers who prefer to mask the earthy taste of CBD.

The number of drops or daily sprays will be indicated on the product packaging. If it is a 5% CBD oil, it is usually recommended that one does not surpass 28 drops per day.

CBD topicals encompass body oils, creams, lotions and salves. Cosmetics infused with CBD are becoming increasingly popular, even items such as CBD lipsticks.

Thanks to the therapeutic and anti-ageing potential of CBD, people look to cannabidiol topicals for targeted relief for many of their skin imperfections and blemishes. Not only can these products provide dermatological relief, but they can also work with joints and muscles that are inflamed or aching.

Symptoms of acne, psoriasis, eczema, chronic pain and rheumatoid arthritis are just some of the conditions that people use CBD topicals to manage. Each of them has visibly improved after CBD administration, according to multiple studies.

In terms of dosing, CBD topicals can be applied as liberally as you see fit unless otherwise stated by the product. They will prove especially effective when applied to an inflamed or sore area. One thing to note about CBD topicals is that, in contrast to other methods of consumption, their effects take place solely in the area of application. Topical CBD will work only with your local receptors on the skin, and will not enter the bloodstream. As a result, the bioavailability of topicals is low.

CBD Capsules, Softgels & Edibles

These are all trusty, conventional methods for taking CBD and perhaps some of the easiest in terms of maintaining a fixed dose.

Capsules, softgels, and edibles such as gummies or chocolate will come with a consistent dose of CBD per capsule. For instance, it may be 10 mg CBD per softgel or per gummy. These options are great if you don’t have the time to mess around calculating the optimal dose of drops.

The disadvantage? Research has demonstrated that orally-taken CBD products do not get absorbed in their full capacity. Indeed, by the time the CBD you consumed orally reaches your bloodstream, it is thought that only 6–20% of the CBD is used. This is because of the powerful enzymes throughout the digestive tract, which begin breaking down the CBD from the moment you swallow it. Your liver then metabolises it further in what is known as the “first-pass” effect.

CBD Patches and Suppositories are two emerging methods for consuming CBD. Both are said to have a high bioavailability, but neither have enough studies behind them yet to confirm this. One study found that rectal application can be 25% to 50% more effective than oral administration, with an average bioavailability of 13.5%. Equally, anecdotal reports claim that CBD patches have good bioavailability, as they travel through our veins through the bloodstream. A rodent study on transdermal patches reported efficacy in relieving symptoms of inflammation of the joints.

When do the effects begin? And how long do they last?

As for the time you may be waiting for the CBD to take effect, this will depend on the method of consumption you choose.

With a method like sublingual consumption or inhaling, you might only have to wait 20 minutes. Conversely, some CBD-infused edibles may take up to two hours to fully digest and reach the bloodstream.

Studies vary in reporting the duration of effects once the CBD is in your system. Some allege that effects may last up to 8 hours, while others claim much less.

How does CBD interact with the endocrine system?

When we take CBD, it eventually reaches the bloodstream (with the exception of CBD topicals). Once in the blood, CBD molecules are transported throughout the body by fatty acid-binding proteins (FABPs). These proteins help lipids, such as CBD, pass through cell membranes.

Once inside the cell, CBD can activate specific receptors. It has been shown to act on CB1 receptors, CB2 receptors, serotonin receptors, GABA receptors, vanilloid receptors, and gamma receptors, among others. It has also been shown to temporarily increase the level of certain neurochemicals in the brain, such as serotonin, anandamide and others. CBD does this by inhibiting a process known as resorption, and is thus sometimes called a “reuptake inhibitor”.

It is also purported to regulate the production of our stress hormone, cortisol, and influence our adenosine receptors, both of which help to manage our moods and sleep cycles.

CBD can collaborate with the other compounds and nutrients found in cannabis and hemp, creating the “entourage effect”. Many scientists believe that this is the key to understanding the unique effects of cannabis and its compounds.

Dosage Recommendations

Dosing sometimes takes a great deal of trial and error, so here are some recommendations that may help you skip the error.

This is the universal standard for drug use, herbal or otherwise. Start with a low dose of CBD and gradually increase it.

For example, a person of moderate weight may take approximately 50 mg of CBD once a day, depending on his age.

We recommend starting with a small dose of 5 mg per day, just to observe your response to any CBD supplement used. From there, you can increase the pace to 2 daily doses of 5 mg. This is important, because CBD can cause side effects in some people. Although these side effects are mild and rare, it is always recommended to start with low doses to avoid these reactions.

Make sure you stick with each dose for at least a few weeks so that your body has time to adapt, before moving on to a stronger dose.

Some brands offer a CBD dose calculator. This will take into account various factors and then produce what is supposedly your optimal dose.

Whilst it may be accurate, you should take their recommendations lightly, as sometimes calculating a dose is beyond the scope of a robotic calculator.

Can I mix different CBD products?

CBD is well-tolerated and usually has few to no adverse effects, providing the consumer adheres to the recommended dosage and uses their products in a responsible way.

So long as you don’t exceed the recommended daily limit, then, most people can safely mix two or more CBD products in a day.

In general, high-speed CBD products offer faster and shorter effects, while slower-start products provide more stable CBD release over a more extended period. If these two types are combined, the consumer can maximise the potential of both products.

Not feeling any different? Here’s why

As we like to remind you, everyone is different. This could mean you are taking the same exact dose from the same CBD oil as one of your friends, but you are responding differently. In some cases, it might not have any effect on you, which is naturally frustrating and convinces you that you have been scammed and that CBD is a marketing fad. Before you reach any rash conclusions, it is important that you consider some of the following possible reasons why your CBD product might not be working for you.

You may be taking the incorrect dose

One of the most critical factors that determine the effect of CBD is the correct dose. If you are not taking the right dose, you are less likely to see any of the results we have promised.

When it comes to dosage, several sources suggest taking 10 to 40 mg of CBD per day; others suggest using 25 mg of CBD every day to see results.

Doses are not fixed, so remember you can increase your dose gradually if you aren’t seeing any results. If you feel a product you have bought does not have a strong enough dose for you, it may be an idea to purchase a stronger concentration, if you are willing to give CBD another chance.

Your dose may be inconsistent

You may be taking 5 mg one day, 10 mg the next and 5 again the day after. It is important that you keep doses consistent and take the same amount every day as you would with regular, mainstream medication.

You may not have waited long enough

Another possible reason why your CBD has not worked is that you have not given it enough time to have an impact on your body. While many users claim that they see immediate results, this is by no means the case for everyone.

Since CBD is not a medicine, but a dietary supplement, it may not always produce rapid results. A minimum of two to four weeks is required before you can expect to feel or see the benefits of the CBD.

If you have waited this long and you still aren’t seeing a difference, it may be time to increase your dose.

Absorption by fat cells

One thing that could prevent CBD from producing effective results is body fat. Cannabinoids attract fats. This means that oils absorb part of the CBD, and only part of it enters the bloodstream. If 60% of CBD is absorbed by body fat, only 40% of the dose is circulated. If oil absorbs 30% of CBD, then 70% of the CBD will circulate around the bloodstream and provide potential benefits.

Research has thus far only focused on certain properties of cannabinoids. There are few studies on fat cells absorption. Still, it is possible to compensate for the effect of fat absorption by increasing your CBD dose.

You may need to switch refinements

If you have been using a CBD isolate and you do not see any benefits, you might want to consider switching to a full-spectrum or broad-spectrum CBD product, in order to get the most out of your CBD intake.

Full-spectrum and broad-spectrum CBD products possess a huge range of other cannabinoids and active plant nutrients, taken straight from cannabis.

These other active plant nutrients may include minerals, vitamins, fatty acids, terpenes, and flavonoids. These compounds are believed to enrich the CBD user experience due to the prior-mentioned entourage effect, which sees the cannabis compounds working synergistically and enhancing the potential effects of one another.

Using a broad-spectrum or full-spectrum CBD, then, could help you see and feel more of the therapeutic effects offered by CBD products, by maximising the entourage effect.

You may be seeking the wrong thing from your CBD products

With CBD, it is important to manage your expectations. Some consumers may enter a CBD regime expecting the world; CBD is not a panacea and will not cure any illness. It may help to manage and temporarily dull various symptoms, but will not totally abolish them.

Perhaps if your CBD goods are not working for you, the problem is that you are expecting too much from them.

CBD will also never get you high, so if you are looking for a mind-altering euphoric sensation from your CBD use, you are looking in the wrong place! Cannabidiol is non-intoxicating, and will not produce a high like marijuana used recreationally would.

Precautionary measures

Despite the fact that research lauds how well CBD is tolerated in the human body, there is always the possibility of adverse reactions when we take CBD.

Hypotension (low blood pressure) may occur in those who are susceptible to this, because CBD may have a hypotensive effect. Measuring and monitoring blood pressure is recommended for people that are vulnerable to low blood pressure.

CBD may also cause:

  • Diarrhoea
  • Headaches
  • Nausea
  • Changes in appetite
  • Changes in weight
  • Drowsiness
  • Fatigue
  • Dizziness

If you encounter any of these reactions, do not continue to take CBD. If you are concerned about your response, contact a doctor.

For those who suffer from a condition to do with the digestive tract (stomach, intestines, colon), sublingual administration is recommended as the best way to take CBD.

CBD is fat-soluble. It thus works best when taken with a food that contains some fat (such as olive oil or coconut oil).

In terms of storage, CBD products should be kept where there is no direct sunlight and do not heat up. Some products may require refrigeration, such as edibles or suppositories. As for expiration dates, do not surpass them.

Key takeaways

It is fair to say there has been a metric tonne of information in this read, so we wouldn’t blame you if you needed a reminder of what we have covered.

  • CBD is a compound that comes from the cannabis Sativa plant species.
  • The endocannabinoid system is the control centre that is affected by the CBD you take.
  • The dosage depends on multiple factors unique to the individual.
  • When looking for a CBD product, always check the ingredients and look for a lab certificate (also known as a certificate of analysis, or COA).
  • CBD concentration is usually measured in milligrams or as a percentage. As the CBD percentage increases, so too does the concentration.
  • In terms of dosing, your BMI, health conditions, current medications and CBD format are all important to consider.
  • Always start with low doses of CBD and work your way to stronger doses.
  • CBD can be inhaled, consumed sublingually, taken orally, topically, or via the anus or the vagina.
  • Depending on how you take CBD, it may take up to 2 hours before you feel its effects.
  • Keep to concentrations of less than 70 mg per day.
  • If you stay within the recommended dosage per day, you can mix different CBD products.
  • You may choose to use an online dosage calculator. If you do, use it as a rough guide.
  • If you aren’t feeling any difference from your CBD consumption, you may be taking the incorrect dose, your dose may be inconsistent, you may not have waited long enough, your CBD may be absorbed by fat cells, you may need to switch to a different CBD refinement, or you may be looking for the wrong thing from your CBD products.
  • Adverse reactions may take place. If you are concerned, seek medical attention and stop taking the CBD.

Onwards and upwards

As you approach the end of this read, you’ll hopefully have the tools to confidently dose your way to a perfect CBD experience. If you feel you may need to revisit certain areas with which you don’t yet feel assured, this guide can be used for future reference for reminding yourself of the basics in dosing CBD.

Remember, dosing can be tricky! So don’t get frustrated if you initially can’t find one that works for you. Perseverance is key!

We will be letting you in on the precise factors that dictate dosages, such as your body weight, age, metabolism and consumption method. We will be educating anyone who needs to know how to source a…

What is the best dosage of CBD for arthritis related symptoms?

Concerning CBD and Arthritis the questions asked regularly are:

How much CBD should I take for arthritis related symptoms?
What is the best CBD oil for arthritis related symptoms?
How does CBD work to effect arthritis related symptoms?
What are the side effects of CBD?

In this FAQ, we will answer the above questions, and walk you through the basics of using Green Flower Botanical’s CBD products.

  1. The FDA Guidelines (legal stuff)
  2. Will CBD Help Arthritis? – The Current Research
  3. Finding Your Minimum Effective Dose – How Much CBD Do I Take And How Often?
  4. How To Determine Dosage Based On Type of Product
  5. Sublingual Oils vs Vapor – Which Are Best?
  6. CBD Side Effects and Drug Interactions

1. The FDA Guidelines Concerning The Use Of CBD Oil For Arthritis

(Let’s get the legal stuff out of the way first)

It is important to note that CBD products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. We are restricted from making any claims about the efficacy of our specific CBD products to treat or cure any disease or medical condition including arthritis.

As of now, the FDA does not recognize CBD as a treatment for arthritis. Therefore, there are no currently established guidelines recognized by the FDA in regard to the proper dosing of CBD (cannabidiol) for treating arthritis or arthritis- related symptoms.

None of the products or information made available to the public is intended to be a treatment protocol for any disease state, but rather are offered to provide information and choices regarding nutritional support for various health concerns. None of the information presented is intended to be an enticement to purchase and should not be construed as medical advice or instruction. The FDA would want us to remind you: You should always seek the advice of a physician before adding nutritional supplements to your diet.

2. Will CBD Help with Arthritis? – What the Current Research Says

Phytocannabinoids, like CBD, are currently showing promise as treatments for pain and inflammation resulting from arthritis. These compounds interact with cannabinoid receptors in areas of the central and peripheral nervous system that modulate pain processing. They also interact with cannabinoid receptors on immune cells signaling those cells to stop producing the inflammatory chemicals that induce pain and inflammation in arthritis. Non-cannabinoid receptors and other mechanisms are still being explored.

Pre-clinical studies involving animals have documented the analgesic and anti-inflammatory effects of CBD. In experimental models of arthritis – where the arthritis is artificially induced in laboratory animals – CBD has been shown to reduce tumor necrosis factor-alpha (TNF-α), and other inflammatory mediators, reduce pain and slow the progression of both osteo and rheumatoid arthritis. 1-3 ( https://www.ncbi.nlm.nih.gov/pubmed/10920191 , https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=53912 , https://www.ncbi.nlm.nih.gov/pubmed/28885454 ) Pain and inflammation were also reduced in a rat model of arthritis using a topical CBD preparation. 4 ( https://www.ncbi.nlm.nih.gov/pubmed/26517407 )

While fewer in number, human studies have also found positive results when using CBD to reduce arthritis-related pain and inflammation. Nonetheless, the clinical evidence available to support the therapeutic use of CBD as a treatment for arthritis is insufficient, in spite of these promising preclinical results.

For your convenience, and to assist with your research, we have assembled an index of published studies on CBD as a treatment for arthritis. For more information on the studies relating to the use of CBD for arthritis therapy, go to this page.

3. Finding Your Minimum Effective Dose: How Much CBD Do I Take And How Often?

Due to FDA regulations we cannot give specific advice on how to use CBD for a particular condition such as arthritis. Fortunately though, the process to find a minimum effective dose of CBD for any condition, is very simple. The key to finding the most effective dosage is by using a Stepwise Dosing procedure.

Stepwise Dosing is a process by which you first establish a baseline dosage, then adjust the dosage incrementally over a set period of time (typically 3 days) until you find your effective dose.

It is important to recognize that everyone responds a little differently to CBD so there is no set dose for everyone or every condition. By following a stepwise dosing procedure you can find the most effective dosage of CBD for you.

The Stepwise Dosing Procedure

Start Low and Go Slow: The first step to finding your minimum effective dose is to establish a baseline dosage. Since many people report good results with CBD at low doses, we suggest you start with a minimal dose and slowly increase the dosage until you find results. Start with a small baseline dosage between 2-5mg, 2X or 3x daily (6-10mg total).

  1. Maintain your baseline dosage for 7 days taking note of how the CBD interacts with your body.
  2. After the initial 7 days of your baseline CBD dosage, if you are not receiving the benefit you need, then increase the daily dosage by 1-2mg every 3 days until you find the dosage that works best for you.
  3. Once you have determined your minimum effective dose you may wish to decrease your dosage by one step to see if you can maintain the benefits at a slightly lower dosage.

Important Note: Typically, people decide to try CBD because of a specific condition, only to find it helps other areas of their body as well. Remember, your endocannabinoid system runs throughout the entire body at a cellular and sub-cellular level. CBD is a whole-body compound. When you start taking CBD for the first time, pay attention to everything going on in your body. Do not be surprised if you find various benefits from your dosage.

About Sleep: Often times, certain conditions or side-effects from medication can create insomnia. Sleep is essential to the bodies healing and recovery process. If sleep deprivation is an issue, you may want to consider weighting your dosage heavier at night to assist with a more sound sleep.

Establishing A Baseline Dosage Based On Weight

If you feel you need a higher dosage as a starting point we have created the following chart to assist you. This chart is submitted as a suggestive guide only and is not meant to take the place of a qualified physician.

dosing chart CBD Oil for Arthritis


4. How To Determine Dosage Based On A Specific Product

Dosing With Sublingual CBD Oils

Once you have established a minimum effective dose using the stepwise dosing procedure, the following chart will help you determine which sublingual oil potency will best meet your daily dosage requirement. To find the best product match for your dosage simply match your daily dosage to the row on the chart labeled “30 Day Supply in Bottle”. For example: If you need 15mg CBD daily then according to the chart you would need a 450mg product. The chart also acts as a guide to how to use the glass dropper to measure out CBD in milligrams.

CBD Oil for Arthritis in mgs

Dosing With CBD Vapor

Once you have established a minimum effective dose using the stepwise dosing procedure above, the following chart will help you determine how to measure milligrams of CBD using either our 250mg or 500mg CBD Vapor Cartridges. As an example, if you needed an 8mg dosage, the chart shows several options to dial-in that dosage using a vape pen. To get 8mg total CBD you could choose to take four 4-second puffs or you could choose two 8-second puffs. A puff is measured by drawing on the vape and counting seconds as 1-1000, 2-1000, etc. Keep in mind everyone will draw their puff a little differently so the values on this chart are only best approximations.

CBD Oil for Arthritis dosing chart

5. Sublingual Oils vs Vapor – Which Are Best?

Looking at the comparison chart you can see the differences between these two popular delivery methods. CBD sublingual oils are taken by placing the desired amount of drops under the tongue and holding for 40-60 secs before swallowing. CBD Vapor is taken by puffing on a vaporizer pen (vape) with the desired CBD vaporizer cartridge.

Many people do not like vaping so the choice to use a sublingual oil is easy. Others may choose a vapor product over a sublingual oil because of the higher absorption rate, faster onset and convenience of carrying it on your person. Some prefer the sublingual oils because the effects last longer, it is easier to dial-in an exact dosage, and easier to take higher dosage servings. Many customers will opt to do both, using the sublingual oil for the main dose and a vape pen to supplement between doses. This is especially helpful for people tackling anxiety or chronic pain who may need to supplement throughout the day.

CBD Oil for Arthritis dosing

6. Possible Side Effects Of CBD And Drug Interaction

There are multiple studies demonstrating the effectiveness of CBD in treating various conditions. Most of these studies conclude that CBD (cannabidiol) is safe and virtually free of side effects.

A review on the Safety and side effects of cannabidiol by the NCBI for example suggests that controlled CBD (cannabidiol) administration is safe and non-toxic in humans and animals. It also does not induce changes in food intake; nor does it affect physiological parameters like heart rate, body temperature or blood pressure. Also, according to this review paper, “high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.”

There are very few known side effects of CBD, these are mostly minor but you should be informed before taking CBD:

  1. Inhibition of hepatic drug metabolism – CBD and other plant cannabinoids can potentially interact with some pharmaceuticals by inhibiting the activity of cytochrome P450, a family of liver enzymes. This key enzyme group is responsible for metabolizing some of the drugs we consume. At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize certain compounds. A 2013 report on a clinical trial using GW Pharmaceutical’s Sativex, found no interactions with CYP enzymes when approximately 40mg of CBD were administered.
    GRAPEFRUIT WARNING: If your medication has a grapefruit consumption warning label then you should not take CBD without first talking to your doctor or pharmacist to see if CBD will inhibit the efficacy of your medication.
  2. Dry mouth- Some people have reported an unpleasant dry sensation in the mouth.
  3. Increased tremor with Parkinson’s at high CBD dosages – There are studies showing the potential of CBD to help alleviate symptoms of Parkinson’s disease. However, there have been reports of CBD increasing tremors when taken at very high dosages. Reducing intake to a smaller dosage will typically eliminate increased tremors.
  4. Lightheadedness – In cases where extremely high dosages of CBD are being taken some people have reported temporary lightheadedness.
  5. Drowsiness – Higher dosages of CBD may cause of drowsiness. If you are affected this way, you should not operate machinery or drive a vehicle. Conversely, due to its bi-phasic nature, micro-doses of CBD act as a wake-inducing agent.

Interactions With Common Supplements:

The most common and widely used supplements to treat arthritis pain are ginger, fish oil, glucosamine chondroitin, and turmeric supplements. To our knowledge, there have been no reports of any harmful interactions between CBD and these commonly used supplements.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking CBD if you are pregnant or breast feeding. Stay on the safe side and avoid use.

1. Malfait AM, Gallily R, Sumariwalla PF, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America. 2000;97(17):9561-9566.

2. Gallily R, Yekhtin Z, Hanus L. Overcoming the Bell-Shaped Dose-Response of Cannabidiol by using Cannabis extract enriched in Cannabidiol. Pharmacology & Pharmacy,. 2015;6:75-85.

3. Philpott HT, O’Brien M, McDougall JJ. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017;158(12):2442-2451.

4. Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016;20(6):936-948.

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Dr. Jamie Corroon, ND, MPH

Dr. Jamie Corroon, ND, MPH

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FDA Disclosure: CBD products are not approved by the FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease.
While we publish and refer to currently available research on cannabidiol, terpenoids and other properties of hemp-derived cannabis oils, it is important to note: None of the products or information available on this website are intended to be a treatment protocol for any disease state. The information presented is for educational purposes only and is not intended to be an enticement to purchase, and should not be construed as medical advice or instruction. Links to third party websites do not constitute an endorsement of these organizations by Green Flower Botanicals, LLC and none should be inferred. The FDA would want us to remind you: You should always seek the advice of a physician before adding any supplements to your diet..

What is the best CBD oil for arthritis related symptoms? How does CBD work to effect arthritis related symptoms? What are the side effects of CBD?