Does CBD Affect Hormones (and is it good or bad)?
This is the most frequently asked question I’ve been hit with lately, and I think its a really juicy one because it highlights the potency that CBD can act within the body.
Q. Does CBD affect hormones?
Hormones are special types of chemical messenger that enable one part of the body to ‘talk’ to another, so the body is constantly operating in synchronous harmony.
Collectively, the hormones and the glands they are released from are known as the endocrine system.
Glands are found throughout the body. Certain glands release specific hormones into the bloodstream so that they can travel to other organs and glands to control their function. This forms a communication network which is giving and receiving constant feedback to maintain optimal bodily function.
Some of the major roles of hormones are:
- Sex drive
Levels of hormones naturally fluctuate depending on whether it’s day or night, and what stage of life a person has reached, eg adolescence, pregnancy or menopause.
Hormones can also become imbalanced throughout any stage of life. These imbalances can be part of the driving force behind chronic illnesses. One of the major challenges we face today is the impact of environmental toxicity on our hormones – plastics, industrial chemicals and pesticides all mess with the endocrine system.
Aside from reducing our exposure to toxicity, we can look for ways to support healthy hormones through the foods, herbs and exercise we engage with.
- Thyroid Hormones
- Growth Hormone
How does CBD affect hormones?
There are three main ways that CBD can change how hormones work in the body.
Cannabinoid receptors are found on major glands throughout the body. When these receptors are activated by our bodies endocannabinoids, this can alter the secretion of hormones, and change their impact on target organs.
Since CBD can also (indirectly) interact with cannabinoid receptors, it has the power to alter the synthesis and secretion of hormones as well.
Most changes in hormone synthesis and secretion start in the hypothalamus, when cannabinoid receptor 1 is activated. This starts a series of hormonal messages that trickle down to other glands, which then secrete their own hormones in response.
Cannabinoid receptor 1 is also found on most other glands and organs, so can control hormonal balance directly as well.
Cannabinoids like CBD can influence the ‘volume’ of message received at a target organ from a hormone. The sensitivity of a cell receptor for a certain hormone can either be increased or decreased by cannabinoids – increasing or decreasing the volume / strength of the message.
Hormones need to be cleared and disposed of after they have done their jobs, so continual balance can be maintained in the body. Cannabinoids like CBD can alter the speed of enzymes that break hormones down.
Although there’s no studies looking directly at CBD on thyroid hormones, there have been some which have looked at the effect of endocannabinoids on them.
Since CBD affects endocannabinoids, we can only speculate as to the effects.
Thyroid hormones TSH, T4 and T3 are all designed to rev up cellular metabolism, helping us mobilise energy to use it.
Endocannabinoids on the other hand encourage the sparing and storage of energy, in part by reducing thyroid hormones (1) .
Blocking endocannabinoids increases TSH, T4 and T3, which may help raise thyroid function (2) .
The effect of CBD could theoretically go both ways, since it can both dampen and stimulate endocannabinoids. Whether CBD may increase or decrease thyroid hormones might depend on someone being hypothyroid, hyperthyroid or having a normal thyroid.
Anandamide was found to suppress TSH only in hypothyroid and normal thyroid conditions (high TSH), and not in hyperthyroid conditions (low TSH) (2) .
This is potential evidence of an adaptogenic effect of (endo)cannabinoids, helping to balance individuals to their own needs. CBD may help endocannabinoids support individual balance.
Testosterone is an important hormone involved mainly in reproduction and sex drive, but also has other roles in regulating mood and energy.
Its mainly synthesised in the testes and ovaries, and is made in repose to hormonal signals from the hypothalamus (LH and FSH).
CBD has been shown to effect LH and FSH levels in monkeys, albeit at doses much higher than we would realistically use. After 90 days, LH and FSH were increased, but no changes were seen in testosterone, except a decrease at the highest dose (3) .
In rats and mice, higher doses (higher than most of us would take) reduced testosterone after 10 – 34 days (4) .
CBD has been suggested to reduce testosterone production by inhibiting the enzyme 17α‐hydroxylase, which makes Testosterone in leydig cells of the testes (4) .
However, CBD also inhibits specific cytochrome p450 enzymes in the liver which break testosterone down (4) .
So theoretically, reducing the breakdown of testosterone may offset reductions in synthesis. But thats just speculation at this point. Also, these studies show a decrease in testosterone at high doses used mid term.
We need to see trials in humans before we can say anything concrete. But for men who want to take a cautious approach:
- Use moderate doses (5 – 100mg/day)
- Cyclical use: take a break every few months to washout accumulated CBD – sweating through sauna and exercise.
- Exercise regularly to promote natural testosterone production whilst using CBD.
Estradiol E 2 ( Estrogen)
Estrogen levels are important because they influence sexual development, fertility, and susceptibility to female diseases such as breast cancer.
Estrogen is made in the ovaries, in repose to hormones LH and FSH released from the pituitary gland. Its levels in the body are also controlled by enzymes that make it and break it down.
Studies using CBD in cells found that it suppresses estrogen production directly, by inhibiting an enzyme that makes it from testosterone, called aromatase (5) .
Aromatase inhibitors are used to reduce estrogen levels in cases of breast cancer and post menopause (6) .
CBD also encourages the breakdown of estrogen by speeding up cytochrome p450 enzymes that break it down (7) .
Theoretically, this points to an anti-estrogenic effect of CBD, lowering levels of estrogen. But this has not been shown in animal or human research so far.
Moderate to high doses of CBD were not associated with changes in LH, FSH and estrogen after 90 days in female monkeys (3) .
More research is needed before any conclusions can be made on how CBD affects estrogen.
Growth hormone (GH), as the name suggests, signals for the reproduction and regeneration of cells, stimulating growth and development in the body.
A few benefits of increased growth hormone output are:
- Strong bones
- Increased muscle mass
- More energy
- Enhanced ability to burn fat
- Improved exercise capacity
A single dose of CBD had no effect on Growth Hormone levels in 11 healthy volunteers (8) .
However other cannabinoids like THC, especially when used long term have been shown to reduce GH. THC reduced GH secretion from the pituitary gland via cannabinoid receptor 1 (9) , and reduced circulating GH levels in adults (10) .
Since CBD also interacts with CB1, long term use could affect GH levels. We need more studies to assess whether there’s a positive or negative effect of CBD on GH levels.
Insulin is a major hormone involved in the use and storage of energy. It has a great impact on body weight and energy levels, via regulating metabolism.
We need insulin to tell our cells when to take in sugar from the bloodstream. Healthy insulin levels mean we use sugar effectively in our muscles and liver, and don’t store too much in fat tissue.
Too much insulin is a driving force of weight gain and diabetes, and its often raised in repose to high sugar consumption.
In diabetic rats, CBD has been shown to reduce excessively high levels of insulin, whilst maintaining blood sugar levels (11) . This means CBD may help sensitise muscles and liver cells to take up sugar more efficiently, helping to maintain stable blood sugar.
CBD also reduces body weight gain in rats (12) . By reducing insulin, CBD may discourage fat cells from storing excessive sugar, which could reduce weight gain.
Unfortunately the only study in humans looking at insulin levels with CBD used a low dose, which did not affect insulin levels in the diabetic patients. However, CBD did increase the levels of another hormone gastric inhibitory polypeptide (GIP) which controls the release on insulin, hinting at a possible effect on insulin with higher doses (13) .
Cortisol’s major role is as a stress hormone, and tells the rest of body that a stressful event is happening. Its produced in the adrenals, in response to sensory inputs to the hypothalamus from our experience of the world around us.
Short term spikes in cortisol are beneficial, as they allow us to be aware of potentially dangerous things in our environment that threaten our survival.
Unfortunately staying on top of bills, work and relationships can also be perceived as a threat to survival, and lead to chronic cortisol output and unresolved stress.
CBD is quite incredible at resolving stress, though. It essentially acts as a breaking system on the stress response, by acting (indirectly) through cannabinoid receptors in the hypothalamus. Effectively, CBD tells the adrenals to chill out on cortisol production.
Human and studies have shown CBD can modulate cortisol output (7) , (14) , (15) , and its one of the major reasons why so many people may find it soothing.
Although there are (initial) changes in hormone levels with CBD, other studies suggest a tolerance can be developed to cannabinoids (16). Initial hormone changes may correct overtime, or are compensated for by other mechanisms (ie hormone receptor sensitivity). So basically, its too early to say with much certainty just how CBD affects hormones long term and what that translates to health wise.
Effects of CBD on hormones:
- Insulin – likely positive
- Cortisol – likely positive
- Thyroid – too soon to say although likely positive
- Testosterone – likely negative if used at high doses for a long time without exercise
- Growth Hormone – too soon to say
- Estrogen – too soon to say
Does CBD Affect Hormones (and is it good or bad)? This is the most frequently asked question I’ve been hit with lately, and I think its a really juicy one because it highlights the potency that
CBD Can Help Restore Hormonal Balance
Studies show that the endocannabinoid system activates receptors in the endocrine system, and that cannabinoids like CBD have an effect on hormones related to sleep, stress, sexual activity, energy consumption, and much more. New cannabinoid therapies for endocrine disorders such as diabetes and menopause bone diseases are expected.
CANNABINOIDS TALK TO THE ENDOCRINE SYSTEM
Just like endocannabinoids, hormones are biochemical messengers involved in many aspects of our physiology. Our growth, behaviour, sleep, sexual function, energy consumption, and mood are all affected by hormones. Even our capacity to evaluate danger and elaborate a proper response depends on these compounds.
These natural regulators are produced by the endocrine system in glands such as the thyroid, pancreas, pineal gland, pituitary gland, hypothalamus, ovaries, and testicles. The hormones released by these glands include melatonin, testosterone, insulin, cortisol, glucagon, epinephrine, and many others. As an example, cortisol is the hormone that manages our response to stress and anxiety, while melatonin indicates to our body when it’s time to go to sleep and when to wake up. Internal or external factors such as ageing, stress, nutrition, and chemicals can unbalance the production of these messengers.
Our endocannabinoid system is closely linked to the endocrine system. Studies have shown that the endocannabinoid system activates receptors in the endocrine system, and that cannabinoid receptors have been found in many different endocrine glands. Consequently, CBD too can activate endocrine receptors in the brain, as much as all over the body.
Studies have shown that this cannabinoid actually interacts with the endocrine system, affecting processes like sleep cycle, stress signals, metabolism, and sexual activity. Some studies even indicate that endocannabinoids can control the proliferation of numerous types of endocrine cancer cells, leading to antitumor effects  . In particular, they are able to inhibit cell growth and metastasis in some kinds of oncologic diseases, such as thyroid, breast, and prostate tumours.
The relationship between cannabinoids and hormone production suggests that these natural compounds may have therapeutic potential for treating endocrine disorders. One of the many challenges for cannabis science today is to understand how the endocrine system can be modulated by CBD and other cannabinoids in order to regulate hormone levels.
CBD AND METABOLIC HORMONES
Diabetes is one of the most common endocrine diseases, caused by reduced insulin production in the pancreas. Insulin balances our metabolism and energy levels by regulating nutrient absorption and storage, and by turning sugars into energy. Insulin imbalances can cause obesity, heart disease, and diabetes.
A wide variety of studies have explored the effects of cannabinoids on metabolism, as well as the relationship between CBD and diabetes. Some of them have shown how CBD impacts pancreas function and insulin production, thus influencing blood sugar levels. Given this newfound role of endocannabinoids in endocrine regulation and energy balance  , the development of a CBD therapy that helps maintain healthy levels of insulin might be one of the next big things for cannabis medicine.
CBD AND SEXUAL HORMONES
In both males and females, the secretion of sex hormones is directly controlled by the pituitary gland and influenced by the hypothalamus. It appears that here too cannabinoids exert an action on the hypothalamic-pituitary-gonadal axis. There is an evident connection between endocannabinoid activity and the production of the female hormone estradiol. The endocannabinoid system has been found to contribute to the regulation of the menstrual cycle. The mechanisms are not well understood, but it appears clear that the endocannabinoid system impacts the release of gonadal hormones. Unfortunately, THC altered hypothalamic-pituitary-gonadal integrity and affected reproductive function in female mice. Chronic CBD exposure promoted impairment in sexual behaviour  and fertility of male mice as well.
One area of cannabis science that’s showing great promise is the treatment of bone and joint diseases with cannabinoids. During menopause, fluctuations and a general reduction in sex hormones result in weaker bones and characteristic loss of bone density in women. Excessive GPR55 receptor activity is involved in this process, leading to bone tissue loss and, eventually, osteoporosis. There’s plenty of research indicating that CBD can inhibit GPR55 receptor activity by helping heal bones and preventing bone density loss. This CBD application may also help support bone health during cross-sex hormone therapies, while also reducing anxiety.
CBD AND SLEEP HORMONES
In the space of a few years, CBD has become widely recognised for its ability to treat stress and anxiety. That’s because among its biochemical interactions with our body, cannabidiol can also influence cortisol levels. In addition, CBD may stimulate the secretion of sleep hormones like melatonin by activating receptors in the pineal gland, thus improving sleep patterns. Moreover, the adrenal insufficiency and consequent fatigue that occurs when the adrenal glands cannot release enough cortisol and aldosterone might be combated by consuming CBD.
SUPPLEMENTING A HEALTHY DIET
Based on what we know so far, CBD is possibly able to improve the symptoms of endocrine disorders and restore hormonal balance, but the healing effects of this and other cannabinoids on hormonal diseases aren’t completely clear yet. Despite the promising results, research in this area is still in the preliminary stages. Success in tailoring a cannabinoid therapy for endocrine disorders would provide patients with natural alternatives to current drugs, yet it’s already safe to say that a daily intake of CBD can be beneficial for our endocrine system. Together with eating lean proteins, leafy greens, and omega-3 fats like the ones contained in hemp seeds, CBD can support hormonal homeostasis.
Cannabinoids can affect the production of various hormones, and CBD might be effective in restoring endocrine system balance.