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The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities

Affiliations

  • 1 PGY-2, Department of Podiatric Medicine and Surgery, Scripps Mercy Hospital, San Diego, CA 92103, United States.
  • 2 Podiatric Surgery Section Chief, Scripps Mercy Hospital, 4077 Fifth Ave, MER35, San Diego, CA, 92103, United States.
  • 3 Department of Podiatric Medicine and Surgery, Scripps Mercy Hospital, San Diego, CA 92103, United States.
  • 4 Private Practice, San Diego Podiatry Group, San Diego, CA, 92108, United States.
  • 5 Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, United States.
  • 6 Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, United States.
  • PMID: 31793418
  • DOI: 10.2174/1389201020666191202111534

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities

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Authors

Affiliations

  • 1 PGY-2, Department of Podiatric Medicine and Surgery, Scripps Mercy Hospital, San Diego, CA 92103, United States.
  • 2 Podiatric Surgery Section Chief, Scripps Mercy Hospital, 4077 Fifth Ave, MER35, San Diego, CA, 92103, United States.
  • 3 Department of Podiatric Medicine and Surgery, Scripps Mercy Hospital, San Diego, CA 92103, United States.
  • 4 Private Practice, San Diego Podiatry Group, San Diego, CA, 92108, United States.
  • 5 Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, United States.
  • 6 Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, United States.
  • PMID: 31793418
  • DOI: 10.2174/1389201020666191202111534

Abstract

Background: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. There has, however, been an increasing body of evidence for the use of cannabinoids in the treatment of chronic, noncancer pain. The efficacy of a topically delivered cannabidiol (CBD) oil in the management of neuropathic pain was examined in this four-week, randomized and placebocontrolled trial.

Methods: In total, 29 patients with symptomatic peripheral neuropathy were recruited and enrolled. 15 patients were randomized to the CBD group with the treatment product containing 250 mg CBD/3 fl. oz, and 14 patients were randomized to the placebo group. After four weeks, the placebo group was allowed to crossover into the treatment group. The Neuropathic Pain Scale (NPS) was administered biweekly to assess the mean change from baseline to the end of the treatment period.

Results: The study population included 62.1% males and 37.9% females with a mean age of 68 years. There was a statistically significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group. No adverse events were reported in this study.

Conclusion: Our findings demonstrate that the transdermal application of CBD oil can achieve significant improvement in pain and other disturbing sensations in patients with peripheral neuropathy. The treatment product was well tolerated and may provide a more effective alternative compared to other current therapies in the treatment of peripheral neuropathy.

Keywords: CBD; cannabis sativa; diabetic neuropathy; hemp; nerve pain; review..

Our findings demonstrate that the transdermal application of CBD oil can achieve significant improvement in pain and other disturbing sensations in patients with peripheral neuropathy. The treatment product was well tolerated and may provide a more effective alternative compared to other current the …

What Patients Should Know About CBD for Peripheral Neuropathy

The pain associated withВ peripheral neuropathy symptoms makes everyday life difficult for patients. And the medication needed to treat the underlying physical symptoms of familial amyloid polyneuropathy can prove too costly for those on a limited budget.

Alternative methods for managing neuropathic pain are available. CBD is an emerging alternative treatment that allegedly has significant pain-reducing qualities.

What is CBD?

Cannabidiol (CBD) is one of the most abundant compounds in the marijuana plant. CBD products come primarily in the form of oils, topical ointments, and infused food items. However, with the exception of one prescription product to treat rare forms of epilepsy, the U.S. Food and Drug Administration has not approved any other CBD products.

Recent clinical research, including a study by researchers at Scotland’s University of Glasgow , looks at CBD’s effects on anxiety, movement, and pain. The study found that a “meaningful proportion” of patients exhibited improvements in sleep quality and pain when administered CBD.

Is CBD for real?

CBD’s impact could be a placebo effect, though the results of the study at the University of Glasgow appear to show otherwise. The emergence of clinical studies corroborating CBD’s pain-relieving qualities and a surge in CBD-based retail stores may offer peripheral neuropathy patients a solution for foot pain.

The plausibility of CBD being a reliable treatment may be subjective. Many peripheral neuropathy patients, including my mother-in-law, find THC products are a suitable method for alleviating neuropathic pain. THC’s alleged calming effects may benefit patients with chronic tingling and burning sensations of the feet, but these effects may not necessarily be true for everyone with peripheral neuropathy symptoms.

Not every patient with polyneuropathy will be quick to adapt to CBD as a solution for pain. My mother-in-law struggles with the side effects of gabapentin: drowsiness, dizziness, and fatigue. This has led her to use prescribed marijuana. Her medical marijuana use has helped alleviate the pain, burning, and tingling in her limbs.

Ultimately, CBD may provide temporary relief from pain with potentially fewer side effects than medicines such as gabapentin.

Note: FAP News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of FAP News Today or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to familial amyloid polyneuropathy.

Columnist Ezekiel Lim says there is key information needed for patients and caregivers considering CBD for peripheral neuropathy.