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best cbd oil for crohn’s disease

Best CBD Oil For Crohn’s – Top 4 Relieving Products

cbd oil dosage for crohn

Crohn’s disease [1] is a chronic, long-term type of inflammatory bowel disease characterized by inflammation in the gastrointestinal tract. It is one of two main types of inflammatory bowel disease along with ulcerative colitis. Both conditions involve an immune reaction against the intestinal tract. Crohn’s disease symptoms [2] are unpleasant and characterized by bloody diarrhea, fever, rectal bleeding, weight loss, and abdominal pain. It is controlled by medications that target the inflammation, including antibiotics, anti-inflammatories, steroids, immune modifiers, or biologic agents. While the exact cause is not understood, it is thought that a combination of genetics, environment, or an overactive immune system may provoke the disease. CBD oil dosage for crohn’s disease is considered a potential cure.

While symptoms may come and go, the onset of symptoms is unpredictable. The treatment goal is the remission of Crohn’s disease symptoms caused by the inflammatory bowel disease process. A special diet is often followed to control the symptoms that include the elimination of alcohol and a restriction of fiber, butter, carbonated beverages, caffeine products, dairy, fatty foods, and corn. Despite the limitations, patients need to maintain a healthy diet because inflammation makes it difficult to absorb nutrients. Avoiding “trigger foods” may help alleviate the inflammatory bowel disease (IBD) symptoms of gas, bloating, and abdominal cramping.

Top 4 Best cbd oil dosage for crohn’s disease (April. 2021)

  • Spruce CBD – Editor’s choice
  • CBD Pure – Best Organic
  • Joy Organics – Best Technology
  • Medterra – Best Price

CBD Oil for Crohn’s

About 15% of inflammatory bowel (IBD) patients report [3] using cannabis to alleviate their symptoms. It appears that medical marijuana has a place in the treatment of IBD. A recent study [4] showed benefits in using 30g marijuana/month that translated into 21 mg THC and 170 mg CBD per day for each of the 173 patients followed. Cannabis decreased the need for other medications. The use of cannabis oil is reported [5] among IBD adolescent patients in another study. Their perceived health benefits from use were on sleep quality, appetite, and nausea.

In the lower digestive tract, endocannabinoids are supposed to protect the gut and reduce motility and inflammation – both of which may lead to the disabling pain associated with ulcerative colitis and Crohn’s disease. Analgesic properties [6] of cannabis products are proposed to be via the TRPV1 endocannabinoid system receptors, and relief is often sought using cannabis oils for the abdominal pain that accompanies the cramping of IBD. The anti-inflammatory effect cannabidiol (CBD) has on tissues should help decrease intestinal inflammation-associated pain. CBD has potent anti-inflammatory activities on pro-inflammatory mediators, making it an ideal choice for the treatment of people with IBD. Read on to find out the best CBD oil dosage for Crohn’s disease.

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Spruce CBD

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  • 100% natural
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The Lineup At A Glance

Best Price

  • No THC
  • Wide variety of products
  • Vegetarian

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Best Technology

  • Free from pesticides
  • No THC products
  • Nanotechnology
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Best Organic

  • CO2 extraction
  • Organic
  • No pesticides
  • Family-run businesses

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Top 5 Best CBD Oil for Crohn’s Disease

Spruce CBD

Take Spruce CBD

Spruce is a family-run CBD brand that offers high-quality, lab-tested, full-spectrum CBD oils made from one of the finest, oldest hemp strains in the United States.

  • 100% natural
  • Family-run
  • Full-spectrum
  • No pesticides
  • High potency available
  • Limited potencies

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Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products and some of the best CBD oils available.

Spruce stands out from the competition in several ways. For instance, it’s a family-run business, which is unusual in the CBD industry.

Its CBD is sourced from a time-tested strain of hemp cultivated in the United States for over two hundred years. The CBD-rich oil is harvested from organically grown hemp from farms in Kentucky and North Carolina.

Spruce is also unique for using a moonshine (alcohol) extraction method to isolate a CBD-rich extract from hemp. Alcohol extraction has proven to be safe and effective.

Spruce’s CBD oils are made with lab-tested hemp extracts, and it provides all of the cannabinoids, terpenes, and other beneficial compounds found in the original plant.

It has a pleasing peppermint taste and comes in 30 ml bottles with two CBD potencies: 25 mg of CBD per ml (750 mg total) and 80 mg of CBD per ml (2400 mg total).

The company carries a wide range of products, including topicals, lotions, balms, tinctures, oils, and capsules.


Medterra oil -2

Medterra manufactures broad-spectrum oil with entourage effects, plus its wide variety of products are all CO2 extracted to yield the best CBD oils for the money.

  • No THC
  • Vegetarian
  • Wide variety of products
  • Limited flavor options

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Medterra is a reputable brand with various CBD products to choose from, including creams, tinctures, edibles, oils, and supplements. Their product line-up includes supplies for your pets.

Their CBD broad-spectrum tincture comes in two potencies, 1000 mg. and 2000 mg. in two flavors plus natural unflavored. CBD oil comes in 500 mg. – 3,000 mg. bottles.

CO2, the gold standard extraction method, can remove THC and impurities from the hemp seed oil to ensure quality CBD oil products.

The wide variety of CBD products all come with a detailed third-party Certificate of Analysis of potency and contaminants. Better yet, it is certified by the U.S. Hemp Authority, which issues guidelines on stringent hemp processing. Third-party testing, as for most products on this list, is conducted on all Medterra products.

MCT is added as a carrier oil and to provide fatty acids. MCT helps the body absorb cannabinoids in the products.


CBDPure CBD Oil_1

CBDPure is a family-run business that offers organically grown hemp at an affordable price.

  • CO2 Extraction
  • Organic
  • No pesticides
  • Family-run businesses
  • Limited flavor choice

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This organic farm began in 2016 in Colorado with a mission to provide the best CBD products on the market. The farm does not use pesticides or herbicides on its organic ranch in Colorado or its ranch in Washington.

The company does third-party testing with the Certificate of Analysis on its products’ purity for downloading off their website. Their Certificate of Analysis outlines the presence of cannabinoids, terpenes, solvents, pesticides, microbial growth, and heavy metals.

All of their products are minimally processed and grown on family-run farms.

They are affordable and even offer coupons to help defray expenses. We can apply these coupons at check-out for all CBD products.

They offer one natural flavor in three different concentrations of full-spectrum hemp oil, 300 mg, 600 mg, and 900 mg in 30 cc bottles.

The company customer service is highly responsive, with a chat window on the website for immediate assistance if needed. They make sure to meet your requirement.

To prove confidence in their product, CBDPure offers a 100% money-back guarantee. If you are not happy with the products, return them within 90 days for a refund.

Joy Organics

Joy Organics CBD Oil

The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten.

  • Free from pesticides
  • No THC products
  • Nanotechnology
  • Family-run
  • Unclear sourcing
  • Not safe for vegans
  • Lack of international shipping

20% Off Coupon: “HEALTHCANAL”

Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids in its oils for a rich entourage effect.. Most CBD oils have a trace of THC in them, but not Joy Organic! Full-spectrum CBD oils are also available with both CBD and less than 0.3% of THC to create the full entourage effect.

The CBD products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these represent standards of quality.

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.

The CBD products come in four flavors, orange, tranquil, natural, and mint. The four flavors come in different potencies, 250, 500, 1000, and 1500 mg per 30 ml bottle.

The oil itself undergoes a process to make it more bioavailable, a nanotechnology

emulsion technique that involves breaking down the molecule into smaller, more digestible components.

CBD Oil Dosage for Crohn’s Disease

The dosage for Crohn’s disease has not been identified in the literature. We have gleaned that too low of a dose is ineffective at treating inflammatory bowel disease (IBD). For example, during eight weeks of treatment with 10 mg cannabidiol (CBD), no significant improvement [7] was noted in 20 patients. Researchers conclude from this study that the dose might have been too low, but they also mention that this was a CBD isolate and do not have the benefits of other cannabinoids for an entourage effect.

In a study of 127 patients undergoing treatment [7] for Crohn’s disease, the dosage used to be effective in intestinal inflammation was 170 mg of CBD in the form of medical cannabis, which also contained THC. This study points to the fact that IBD patients may need a higher dose than 10 mg to exert the necessary anti-inflammatory effects and impact functional symptoms. It also may indicate that using a CBD isolate may perform differently than full extracts from the cannabis sativa plant with all the entourage effects.

In animal models, research has shown positive effects on inflammation in the gut by rectally administering cannabidiol at a dosage of 20 mg/kg. This study indicated a possible role [8] for topical administration directly into the gut mucosa to help decrease inflammation.

In another study on rats, cannabinoids [9] that included THC, at a dose of 10 mg/kg showed a reduction in inflammation and functional symptoms. The dosage curve followed a bell-shaped pattern.

Before trying CBD for gut inflammation, one should seek medical advice, diagnosis, or treatment first as the dosage for this cannabinoid needs tailoring to the individual and drug interactions assessed before administering any dose. Involving the health care system in your decision to use CBD oil will facilitate coordination of treatment.

How Does CBD Oil Help Crohn’s Disease

Cannabinoid receptors 1 and 2, endogenous cannabinoids, and atypical cannabinoids are upregulated in inflammation [10] , and their presence and stimulation aggravate colitis. In contrast, cannabinoid receptor antagonism and cannabinoid receptor-deficient animal models reverse these anti-inflammatory effects. The endocannabinoid system is implicated [11] in gut homeostasis, regulation of intestinal motility, visceral sensation, inflammation, and being recently involved in treating IBD.

Another study demonstrated [12] a role for cannabinoids in reducing intestinal permeability and reducing inflammation and regulation of intestinal bacteria, especially as it related to alcohol use disorders. All of these factors can play a role in symptomatic flare-ups in patients with IBD.

How to Take CBD Oil for Crohn’s Disease

Many people turn to CBD with and without medical advice. Those who may not use CBD may use cannabis to control their pain, weight loss, nausea, and other side-effects of their illness. Cannabis or CBD might play a role in increasing the quality of life for patients with IBD.

You can take CBD in the form of oils, tinctures, capsules, or applied topically in the form of lotion, balms, or creams. For patients with IBD, the best way to take CBD is orally or through the bloodstream by putting tinctures or oils under the tongue or inhaling the oils’ vapors. One might achieve significant health benefits from incorporating the many CBD products on the market into their lifestyle.

Research on CBD and Crohn’s Disease

To date, most of the research has been on cannabis-related products containing a mixture of THC and CBD. The problem is, THC is not legal in every state, and not all people want the “high” effects associated with the use of such products. For this reason, hemp-extracted CBD products are being explored as a treatment option for IBD. The problem with researching CBD oil dosage for crohn’s disease is that the Food and Drug Administration has only patented one CBD drug, which was for epilepsy. It has not been approved for the treatment of this disease.

In a novel approach, a patented enema [13] (all rights reserved) formulation containing CBD has been introduced into the market. The enema protects the intestinal permeability barrier, controls diarrhea, and improves microbiome function. It was explicitly designed with IBD patients in mind after an extensive medical review of the literature.

Still, in light of all the positive data on how CBD might help people with IBD, the medical system seems reluctant to embrace its therapeutic values in health promotion and disease prevention. Many patients could achieve significant health benefits from the use of these products. However, the bottom line is, more research study is in need.

Frequently Asked Questions

Many people turn to CBD for their pain relief and to benefit their overall health. People with IBD have no guidance on dosage for their condition because the FDA has not approved it for use in treating the side-effects associated with IBD. From a review of the studies, it seems that too low of a dose is ineffective at treating symptoms such as weight loss or pain, but the bell-shaped curve present in other dosage studies indicate there might be a “sweet spot” or dosage where symptoms resolve, but a
higher or lower dose will not have the same remission effects. The best thing to ask for medical advice from your healthcare provider.

CBD might help people with IBD manage their health better by decreasing their disease’s symptoms through pain reduction and anti-inflammatory actions. However limited, studies have shown beneficial effects on IBD symptoms in both animals and humans with the use of CBD.

Chemo and Hash plant, both Indica strains, are suitable for Crohn’s disease. Lemon
Jack, Golden Pineapple, and K2 are other strains good for this disorder.

Spruce’s 2,400 mg full-spectrum CBD delivers 80 mg of CBD per 1 milliliter (ml) dose,
which is equivalent to a full dropper.

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Crohn’s & Colitis Foundation. (2020). What Is Crohn’s Disease? Available from:
  2. Crohn’s and Colitis. (2016). WHAT ARE SYMPTOMS OF CROHN’S DISEASE? Available from:‌.
  3. Expert Review of Gastroenterology & Hepatology. (2020). An overview of cannabis based treatment in Crohn’s disease. Available from:‌.
  4. Naftali, T., Bar-Lev Schleider, L., Sklerovsky Benjaminov, F., Lish, I., Konikoff, F.M. and Ringel, Y. (2019). Medical cannabis for inflammatory bowel disease. European Journal of Gastroenterology & Hepatology. Available from:‌
  5. Hoffenberg, E.J., McWilliams, S., Mikulich-Gilbertson, S., Murphy, B., Hoffenberg, A. and Hopfer, C.J. (2019). Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 68(3), 348–352. Available from:‌
  6. Barrie, N. and Manolios, N. (2017). The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. European Journal of Rheumatology, 4(3), 210–218. Available at:
  7. Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M. (2017). Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial. Digestive Diseases and Sciences, 62(6), 1615–1620. Available from:
  8. ‌Schicho, R. and Storr, M. (2012). Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice. Pharmacology, 89(3–4), 149–155. Available at:‌
  9. Jamontt, J., Molleman, A., Pertwee, R. and Parsons, M. (2010). The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation andin vitromotility disturbances in rat colitis. British Journal of Pharmacology, 160(3), 712–723. Available from:‌
  10. Leinwand, K.L., Gerich, M.E., Hoffenberg, E.J. and Collins, C.B. (2017). Manipulation of the Endocannabinoid System in Colitis. Inflammatory Bowel Diseases, 23(2), 192–199. Available at:
  11. Alhouayek, M. and Muccioli, G.G. (2012). The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends in Molecular Medicine, 18(10), 615–625. Available from:‌
  12. Karoly, H.C., Mueller, R.L., Bidwell, L.C. and Hutchison, K.E. (2019). Cannabinoids and the Microbiota–Gut–Brain Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders. Alcoholism: Clinical and Experimental Research, 44(2), 340–353. Available from:
  13. ‌Price, S. (2020). CBD and inflammatory bowel disease: not just a gut feeling. Health Europa. Available from:
Kathy Shattler, MS, RDN

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.

Having crohn's disease doesn't mean you have to deal with its symptoms. Here are the best CBD oil dosage for crohn's disease in 2021!

The Benefits of Hemp Oil for IBD

cindy frei

Jan 20, 2018 · 7 min read

My 14 year old son has Crohn’s disease — with an extra bonus of severe anxiety on top. In the last 6 years he has had more procedures than I can count, and been on almost all of the meds available to children at this time, including a g-tube providing enteral nutrition. As I look ahead to his future, I find myself panicked that we have almost used up all of our cards available and he is only 14. As his mom, it’s been my mission to figure out the best way to take control of the situation, and not just wait for the bottom to drop out again. We recently discovered the benefits of Hemp oil and I feel like this could be a big piece of the puzzle.

The Impact of Diet on the Microbiome

I have educated myself about the microbiome and how food can impact the gut and immune system. I’ve transformed our diet and have become loyal followers of the SCD. Once we changed his diet, deep remission (in conjunction with Humira) settled in. While I know one size may not fit all, I believe a healthy diet will give our son his best chance of staying ahead of this disease. When Humira is no longer a viable option (which I’ve been told is only a matter of time), we want to be prepared and not scrambling to determine next steps. We should all eat this healthy and teach our children to eat for health and long-term wellness. The medical community seems to be coming around to nutrition as a treatment option which is exciting….dump the junk as they say, we’ll all be better off.

Seeking Alternatives to the Traditional Piles of Pills

So like many families, Crohn’s hasn’t been our only issue. Between myself, my husband and our children we enjoy a myriad of issues, including autoimmune issues, anxiety, insomnia, kidney stone pain, and headaches. I’m going to go ahead and say it…..

“things have gone a little haywire in our house over the last few years”

and we have been seeking alternatives to the traditional piles of pills (and their side effects) that the doctors would have us take.

I believe there is a place for medicine, but there also is a BIG place for eating the right foods, and taking the right supplements to help balance our bodies more systemically, instead of just treating symptoms.

The Benefits of Hemp Oil

Enter hemp oil. After a lot of research, and anecdotal stories, I have officially become a big fan of using hemp oil. A plant-based, pure premium grade hemp oil (aka CBD oil) has made it’s way into our daily supplement cabinet and I truly believe that it has a major impact on all of the systems in our body.

The non-technical explanation is that hemp oil has shown to activate and help manipulate the endocannabinoid system within our body, which creates the opportunity for all our major systems to work like they should in the first place

It sounds a little ‘out there’, but the science is there. In fact, it’s been there for hundreds of years.

I remember years ago watching in amazement during a news report showing children receiving medicinal marijuana for epileptic seizures — it stopped them in their tracks. I’ve seen the research on medicinal marijuana used with cancer patients to eliminate nausea from chemo use and interrupt tumor growth. I’ve watched the series that follows the scientist who discovered this plant and it’s medical uses.

I’m obviously not a scientist, but the hundreds of stories I have heard (on top of the research and peer-reviewed journals), there is undeniably something to this. Researchers say that this oil works to ultimately:

  • balance the immune system and calm inflammation
  • support healthy neurological function and
  • promote tremendous mood support, among other things.

Every day, people are successfully using hemp oil to help with everything from sleep disorders, migraines, anxiety/depression and ADHD to chronic pain, seizures and autoimmune disorders.

I’m actually first-hand witnessing my friends and their friends and their friends start the oil and experience great relief. And in the world of the many Crohn’s groups on Facebook that I follow, the hemp oil has and continues to be a hot topic. So many people are convinced that the hemp oil is working and they are sharing their incredible stories. One blogger says, “…CBD has given me back a quality of life that years of debilitating pain and piles of prescription medications made me feel like I could never find again.”

Difference between Hemp, CBD, Medicinal Marijuana, Cannabis, Pot etc.

You have probably heard a lot of chatter out there about this stuff, but there is SO much confusion and misinformation about it. What is the difference between hemp, CBD, medicinal marijuana, cannabis, pot, etc.? The very simplified explanation is that cannabis is a plant that has two species: marijuana and hemp.

  • Marijuana contains a high percentage of THC, which is the chemical compound that creates the ‘high’, and a very small percentage of CBD (or cannabinoids), which is the medicinal part.
  • The Hemp plant, on the other hand, contains a high percentage of cannabinoids and trace amounts of THC (which is completely undetectable on drug tests, thus making it now legal in all 50 states).

So now that scientists have finally figured out how to separate the CBD from the THC, the resulting hemp extract oil is creating a frenzy because it seems to be working phenomenally well. You get the medicinal benefits, without the psychoactive effect. The benefits of Hemp Oil are becoming quite apparent.

In fact, Forbes magazine reports that within the first three years of hemp oil being available, the industry is already on it’s way to hit $1 billion in sales.

Wow. But you definitely have to do your research because there are many hemp oil products on the market that aren’t premium grade and are very low in cannabinoid concentration. Many aren’t pure and have a very low absorption rate because of their formulation. Prices seem to range dramatically, which is one clue as to the quality. Also interesting to note is that many major pharmaceutical companies are already working on their own formulations, so this will clearly go beyond the supplement market. One such company has already filed a patent on the term “CBD” which is now forcing the current makers of the oil to only use the term “hemp oil.” Hmmm.

So, we have only been using hemp oil for a month, but have successfully weaned our son off of all anxiety medications. So, we’re already seeing the benefits of Hemp oil. Are we ready to stop the Humira? Absolutely not, as he’s entering puberty and seemingly doing well, we are not prepared to rock the boat at this time. But I do feel strongly that having the diet and the hemp oil on board provides a bit of peace of mind, a safety net, as we have no idea what’s ahead in this journey with Crohn’s disease.

We’ve discussed the hemp oil use with our son’s pediatric GI and she says that while there still aren’t enough large scale trials to absolutely prove, it’s safe and there are no known side effects. Years ago when we discussed using diet in the management of disease, we got that very same answer. Sometimes it seems modern medicine takes a long time to endorse new approaches, that’s fine and I understand, but that doesn’t always mean it shouldn’t be attempted if safe. What do we have to lose? Oh and a side note, the headaches and sleep issues are now a thing of the past.

After a lot of research, I personally believe in the brand formulated by Dr. Christopher Shade called Prime my Body.

  • It contains a broad spectrum of cannabinoids, not an isolate as in other oils.
  • It has strict standards for purification.
  • It uses the latest methods available for 5–10 times the absorption rate of other brands.
  • It is nano-enhanced, and uses liposomal delivery.

You take the oil by squirting a few pumps under the tongue so it’s absorbed into the bloodstream and delivered to the cells almost immediately. Do your own research, talk to your friends. That’s what I did and this is where we landed.

Here are some additional resources on CBD for your reference:

My 14 year old son has Crohn’s disease — with an extra bonus of severe anxiety on top. In the last 6 years he has had more procedures than I can count, and been on almost all of the meds available to…