Posted on

best cbd oil for alzheimer’s

Cannabis, CBD oil and dementia

Currently there is no evidence to show that cannabis or cannabis oil (CBD oil) can stop, reverse or prevent dementia.

Can cannabis or CBD oil treat dementia or its symptoms?

There are no research studies that prove cannabis, or products such as cannabis oil (CBD oil), can stop, slow, reverse or prevent the diseases that cause dementia.

Some studies suggest cannabis could help to manage a few behavioural symptoms of dementia, such as agitation and aggression.

But more research is needed to understand the long-term effects of taking cannabis, and whether it is an effective and safe way to tackle dementia symptoms.

If you have any questions or concerns about cannabis use and the risk of dementia or other brain disorders, please talk to your GP.

Read our advice to help reduce your risk of developing dementia.

What is cannabis?

Coconut oil and dementia

Cannabis, also known as marijuana, is a plant. The dried leaves, flowering parts or resin extracted from the plant is taken recreationally.

Cannabis is made up for two main components – Tetrahydrocannabinol and Cannabidiol.

What is Tetrahydrocannabinol (THC)?

THC is the main component of cannabis that invokes feelings of sociability, happiness or relaxation.

Products containing more than 0.2% THC are not legally available in the UK.

What is Cannabidiol (CBD)?

Cannabidiol or CBD does not cause any psychoactive or intoxicating effects.

Products that contain CBD are legal and can be bought on the high street or online.

Is there any evidence behind the cannabis and CBD oil claims?

There have been no clinical trials on the effects of cannabis or CBD oil in people living with dementia.

In the lab

A key hallmark of Alzheimer’s disease is the build up of clumps of a protein, called amyloid, in the brain. Some studies have shown that components of cannabis, including THC, appear to remove this protein from nerve cells grown in the lab.

Another study that gave both THC and CBD oil to mice with symptoms of Alzheimer’s disease showed an improved in learning and had less evidence of amyloid clumps in their bodies.

Research continues to better understand the effects of CBD oil on the brain. Some early evidence suggests that CBD oil may reduce inflammation in the brain, although this has yet to be proven in people.

The truth about clinical trials: 5 big myth busters

Dementia researchers Jason and Harri from UCL

Tackling the symptoms of dementia

Research does suggest that high concentrations of CBD oil could be useful for managing some of the symptoms of dementia such as agitation and anxiety.

A few small clinical trials have assessed the effects of cannabinoids (including THC and synthetic cannabinoids, such as nabilone) on behavioural symptoms of dementia. However, trials and studies so far have generally been small or low quality making it difficult to come to a conclusion.

It is also important to note that the researchers in these studies have used high concentrations of CBD oil that may not be available to buy. These studies have also been short term so we still don’t know what the long term effects of using CBD oil might be.

A study is currently underway at King’s College London that will look at whether a mouth spray containing cannabinoids could be used to reduce symptoms of agitation and aggression in a small group of people with Alzheimer’s disease.

Treating and preventing dementia

The jury is still out on whether cannabis or its by-products could be used to treat dementia. A lack of strong research studies mean that dubious and anecdotal reports have taken the place of hard evidence.

No studies or trials have looked into the effects of cannabis or its components on the underlying causes of Alzheimer’s disease in people.

Whilst the studies in the laboratory show some promise, we need to understand the wider effects that these components have before we can know whether they have any effect – positive or negative – on the development of Alzheimer’s in people.

There is some evidence that heavy, long-term use of cannabis could have a negative effect on our memory and thinking. Much more research needs to be done to tease apart any potential benefits and drawbacks.

It is also worth noting that many of these studies have involved a particular component of cannabis in isolation. Even if one component is found to influence dementia risk, it doesn’t necessarily mean that taking cannabis would have the same effect.

There is also a large amount of variation in the levels of THC and CBD oil in different strains of the plant so the effects could depend on the type of cannabis used.

Has Alzheimer’s Society ever funded research into cannabis and dementia?

Alzheimer’s Society has never funded research into cannabis and dementia risk, or into cannabis as a potential treatment for dementia symptoms.

This is because we have not received any high-quality applications from researchers intending to investigate these issues.

If we received a high-quality application into cannabis and dementia from a researcher based at a UK university, research institute or NHS trust, then we would certainly consider this for funding.

Currently there is no evidence to show that cannabis or cannabis oil (CBD oil) can stop, reverse or prevent dementia.

Best CBD Oil For Dementia 2021 – Top CBD Oil For Alzheimer’s

best cbd oil for dementia

As we get older, our bodies continue to change. Issues like stiff joints and chronic pain become an everyday reality and our bodies don’t recover as quickly as they once did. While some of the most noticeable consequences of aging are physical, there are mental effects as well. What many people don’t realize, however, is that deterioration in memory, thinking, and behavior isn’t a normal part of life. These are the hallmarks of dementia.

Dementia is a chronic, progressive syndrome characterized by deterioration in cognitive function. According to the World Health Organization (WHO), it affects as many as 50 million people [1] around the world and there are nearly 10 million new cases each year.

There is no cure for dementia and research is ongoing to better understand its underlying causes and risk factors. In this article, we’ll explore the different types of dementia and how alternative therapies like cannabidiol (CBD) oil may be able to help you or a loved one manage dementia. Find out more about the best cbd oil for dementia here in this article.

The Best CBD Oil For Alzheimer’s (April. 2021)

  • Spruce CBD – Editor’s Pick
  • Endoca – Best Quality
  • CBDfx – Best Value
  • Plus CBD – Best Flavor

CBD for Dementia

The cause of dementia is unknown which makes treatment difficult. There is no current treatment known to cure dementia or to alter its progressive course, but new treatments are constantly being developed and tested in clinical trials. For now, dementia treatment typically focuses on support measures to improve the quality of life for patients and their families.

Though CBD oil has not been proven to prevent, stop, or reverse dementia, the results of several research studies suggest it may provide benefits in managing certain behavioral issues. CBD also offers anti-inflammatory, antioxidant, and anxiety-relieving benefits [2] which could be helpful for patients with various forms of dementia.

Read on to learn more about CBD oil for Alzheimer’s disease and other forms of dementia. You’ll also see our top picks for the best CBD oil.

Take Spruce CBD

Spruce CBD

Why is it better?

  • 100% natural lab-grade CBD oils
  • Third-party tested for purity
  • Available in several concentrations

Free Shipping and 15% Off Coupon: HEALTHCANAL

The Lineup At A Glance

Most Affordable

  • Non-GMO organic hemp oil CBD
  • Third-party lab tested for safety and purity
  • Backed by 90-day money-back guarantee

Free Shipping and 15% Off Coupon: “HEALTHCANAL”

Best THC-Free

  • Organic broad-spectrum CBD oils
  • Available in several flavors (and unflavored)
  • Free shipping and money-back guarantee

20% Off Coupon: “HEALTHCANAL”

Best Variety

  • Available in several concentrations (up to 3,000mg)
  • Broad-spectrum formulas are free from THC
  • Wide variety of products to choose from

15% Off Coupon: “OFFER15”

Best Flavor

  • Available in several flavors (and unflavored)
  • High-quality full-spectrum hemp CBD
  • Choose from several different concentrations

15% Off Coupon: “HEALTHCANAL”

Top 5 best cBD oil for dementia Selections

Spruce CBD

Take Spruce CBD

When you need reliable relief, you need a high-quality product like Spruce CBD. Made with full-spectrum CBD oil, these products are pure and potent.

  • Made with lab-grade full-spectrum CBD
  • Third-party lab tested for purity and potency
  • Choose from 750mg or 2,400mg
  • Somewhat expensive compared to others
  • Limited variety of products to choose from

Free Shipping and 15% Off Coupon: HEALTHCANAL

Though Spruce CBD may only offer two standard CBD oils and one limited-edition flavor, you can trust their products to deliver on purity and potency. Choose from a 750mg or 2,400mg concentration and rest easy knowing you’re getting 100% natural, lab-grade CBD. These oils have a natural flavor and are completely free from THC. Receive free shipping and save 15% when you subscribe for regular monthly deliveries.


CBDPure CBD Oil_1

You and your loved ones don’t have to worry about any unnecessary ingredients or harmful additives with CBD Pure’s high-quality, organic CBD oil.

  • Non-GMO organic hemp oil CBD
  • Third-party lab tested for safety and purity
  • Backed by 90-day money-back guarantee
  • Limited variety of product choices

Free Shipping and 15% Off Coupon: “HEALTHCANAL”

While some companies fill their products with artificial flavors and other additives, CBD Pure keeps it pure and simple. Their cannabis products are made with certified non-GMO organically grown hemp right from Colorado and Washington. Their oils are free from contaminants and, just to be sure you’re satisfied, they’re backed by a 90-day money-back guarantee. Every product is lab-tested for quality, purity, and potency as well.

Joy organics

Joy Organics CBD Oil

Whether you’re new to CBD or not, it’s always nice to have the certainty that your product contains quality CBD oil and nothing more. That’s why you can trust Joy Organics.

  • Organic broad-spectrum CBD oils
  • Available in several flavors (and unflavored)
  • Free shipping and money-back guarantee
  • Some users may be confused by full vs broad spectrum
  • Can be a little pricey compared to others

20% Off Coupon: “HEALTHCANAL”

If you’re looking for a high-quality CBD oil, look no further than Joy Organics – especially if you want something completely free from THC. This company offers both full-spectrum and broad-spectrum CBD so you can get exactly what you want. Plus, their oils come in several different flavors, including an unflavored option. Everything is third-party lab tested and backed by a money-back guarantee. You’ll even get free shipping!


Medterra oil -2

Even if you’ve been using hemp products for a while and know what you like, it can always help to have a bit of variety when it comes time to shop. That’s where Medterra comes in.

  • Available in several concentrations (up to 3,000mg)
  • Broad-spectrum formulas are free from THC
  • Wide variety of products to choose from
  • Some may be confused about full vs broad spectrum

15% Off Coupon: “OFFER15”

Medterra offers a wide variety of hemp CBD products including highly concentrated tinctures with up to 3,000mg of CBD. Their products are made with GMO-free, organically grown CBD made in the USA and everything is free from THC as well. Medterra CBD products are lab tested for safety and you can find Certificates of Analysis directly on the website.

Plus CBD

Plus CBD Oil-1

Hemp oil has a distinct flavor that some people simply don’t like. If you’re looking for an unflavored option or something to mask the taste, go with Plus CBD.

  • Available in several flavors (and unflavored)
  • High-quality full-spectrum hemp CBD
  • Choose from several different concentrations
  • Can be a little pricey compared to others

15% Off Coupon: “HEALTHCANAL”

Whether you’re struggling with Alzheimer symptoms or another type of dementia, CBD products may help alleviate pain, inflammation, and more. If you’re not sure you like the flavor of hemp oil, you’ll be glad to know Plus CBD offers a variety of flavors like Peppermint and Goji Berry – they also offer unflavored options. Plus CBD oils come in drops as well as sprays for easy administration and you can choose from a variety of concentrations.

What is Dementia?

Dementia is a syndrome [3] rather than a disease. It is a general term for diseases that cause changes in cognition and memory severe enough to impact the individual’s daily function. Alzheimer’s disease (AD) is the most common form of dementia [4] – others include vascular dementia, Lewy body dementia (LBD), mixed dementia, and more.

The symptoms of dementia vary from one patient to another but most forms of the disease lead to a gradual worsening of symptoms over time. These changes are caused by progressive damage to the nerve cells in the brain known as neurodegeneration. For the most part, we can divide these symptoms into three stages:

  • Early Stage
  • Middle Stage
  • Late Stage

During the early stages of the disease, dementia patients typically experience a gradual onset of minor symptoms like forgetfulness or losing track of time. As the disease progresses, the symptoms become more noticeable and more restrictive. Dementia patients may become forgetful of names or recent events and may have increasing difficulty with communication and personal care. Some patients also experience behavioral changes like wandering.

In the late stages of dementia, patients often become totally dependent on others for care. Physical symptoms become more pronounced such as difficulty walking. Alzheimer’s patients and individuals with other forms of dementia eventually have difficulty recognizing friends and family, and may develop behavioral and psychological symptoms [5] such as agitation and aggression. In many cases, death in dementia patients may occur for another condition.

Types of Dementia

The term dementia refers to loss of memory and cognitive decline caused by physical changes in the brain tissue and cells. There are many different types of dementia, though Alzheimer’s is the most common form. Alzheimer’s disease affects as many as 5 million people [6] and symptoms typically appear after age 60 and increase with age. This condition is characterized by degeneration of brain cells linked to a microscopic protein fragment called beta-amyloid.

Some of the other common forms of dementia include:

  • Frontotemporal dementia
  • Vascular dementia
  • Huntington’s disease
  • Parkinson’s disease
  • Lewy body dementia
  • Korsakoff syndrome

Frontotemporal dementia is characterized by progressive nerve cell loss in the frontal lobes of the brain or in the temporal lobes. This condition typically causes progressive deficits in behavior [7] , language, or executive function. Vascular dementia, on the other hand, involves reduced or blocked blood flow to the brain [8] which causes a decline in cognition.

Huntington’s disease [9] is a progressive neurodegenerative disorder linked to a defective gene which causes changes in the central nervous system. Parkinson’s typically affects movement but eventually progresses to mental function. The brain changes linked to this disease are called Lewy bodies – they are microscopic deposits of abnormal protein [10] in the brain. Lewy body dementia also links to these brain abnormalities while Korsakoff syndrome is a disorder caused by severe deficiency of vitamin B1 (thiamine).

In addition to these forms of dementia, some patients experience mixed dementia – a condition in which changes in the brain are caused by multiple factors. The most common form of mixed dementia [11] combines the abnormal protein deposits associated with Alzheimer’s disease with the blood vessel issues associated with vascular dementia.

CBD Oil Benefits for Alzheimer’s and Dementia

To understand the potential of CBD oil for Alzheimer patients and other types of dementia, you need to know the basics about how this substance works. Cannabidiol (CBD) [12] is a nonintoxicating compound extracted from the cannabis plant – specifically Cannabis sativa. This compound might offer a wide range of benefits linked to its impact on the endocannabinoid system (ECS) in humans.

The ECS plays the role of a “master regulator” [13] in the body, impacting essential functions like metabolism and cellular communication while also helping the body maintain homeostasis. An increasing body of research suggests the ECS may regulate neurodegenerative processes [14] as well, including oxidative stress, glutamate production, and neuroinflammation. Because neurodegeneration is a common feature of dementia, it has led researchers to wonder whether cannabinoids like CBD may be beneficial in managing the effects of these diseases.

Reducing Oxidative Stress Damage

Cannabidiol is one of the primary active phytocannabinoids found in the cannabis plant. Though it doesn’t have the psychoactive effects of THC, it exerts a variety of beneficial pharmacological actions, namely anti-inflammatory and antioxidant properties. Though much of the scientific research conducted on the antioxidant effects of CBD has been related to cancer, scientists recognize its potential role in the prevention of neurodegenerative diseases [15] .

Oxidative stress [4] is a molecular mechanism shared among all types of dementia along with neuroinflammation and neurodegeneration. As such, the antioxidant properties of CBD could benefit Alzheimer patients and patients with other types of dementia. One study in particular [16] tested CBD’s ability to attenuate oxidative stress and reduce the generation of reactive oxygen species (ROS) in Alzheimer patients. CBD was found to suppress pro-inflammatory signaling in addition to reducing oxidative stress.

Reducing Inflammation

Cannabinoids like CBD and THC act directly on the endocannabinoid system and, in doing so, play a role in the release of neurotransmitters and impact various biological processes. One of these processes is the body’s inflammatory response. Specifically in regard to neurodegenerative diseases, CBD has been studied for its potential therapeutic applications in relieving neuroinflammation.

According to a review [17] published in the British Journal of Clinical Pharmacology, the anti-inflammatory benefits of cannabidiol make it an interesting option in the treatment of neuroinflammation. Furthermore, its combination of anti-inflammatory and antioxidant properties offers strong neuroprotective potential, particularly in regard to neurodegenerative disorders.

Promoting Brain Cell Growth (Neurogenesis)

Neurodegeneration is the hallmark of dementia and it is progressive. Though no cure for dementia has yet been found, scientists are studying potential treatments which may slow or even reverse neurodegeneration through the process of neurogenesis [18] . Neurogenesis is the process through which new neurons are formed in the brain. Generation of these brain cells is particularly important during embryonic development but continues in certain parts of the brain throughout life.

Two in-vitro studies in mice [19] support the use of CBD to stimulate neurogenesis. In these studies, CBD supported neurogenesis in the hippocampus, the part of the brain that plays a major role in learning and memory. In a scientific review published in 2016 [20] , researchers found support for the neuroprotective benefits of CBD in humans along with its potential to facilitate neurogenesis. More research is needed to study these effects.

Regimen for CBD Usage

If you’re considering CBD for yourself or a loved one, it’s important to find the right dose. There is no standard dose of CBD, however, so it can be tricky. Here are our recommendations:

Daily Maintenance

When using cannabidiol for daily symptom management, it’s generally best to start off at a low dosage. What constitutes a low dose is generally determined by your weight – about 10mg per 100 pounds of bodyweight is a good place to start. Pay attention to your symptoms over the first 7 days of taking the CBD then consider increasing the dose if you aren’t seeing the results you want. Increase by 1 to 2 mg every three days until you find the proper dose.

Managing Flare-Ups

With chronic and progressive conditions, flare-ups are always a possibility. Once you’ve established your ideal daily dosage of CBD, you may find you need to take a little more on some days to manage flare-ups. Again, you may want to keep the increase minimal until you are able to discern the effects on your body.

Finding the right dose of CBD is often a matter of trial and error, so be patient. Talk to your doctor about where to start and check in often about your symptoms until you find the right dose that works for you.

Does CBD Affect Memory?

If you’re considering using CBD products to manage symptoms of Alzheimer’s patients, you may be wondering about the risks. After all, marijuana use has been associated with short-term memory loss [21] and the last thing dementia and Alzheimer patients need is more loss of memory. Some researchers suggest this has more to do with the THC content, however, than CBD.

The good news is CBD hasn’t been associated with memory loss and its potential neuroprotective benefits could even improve various aspects of cognitive function including memory. In one study [22] researchers found that CBD treatment continued over 8 months helped prevent the development of social recognition memory deficits in mice. Whether these benefits translate to humans is unclear.

At this time, there isn’t sufficient scientific evidence to say whether CBD has a positive impact on memory. That being said, there also isn’t significant evidence to suggest that it has a negative impact either. Talk to your doctor before taking best CBD oil for dementia & Alzheimer symptoms like memory loss, just to be safe.

Frequently Asked Questions

No, there is currently no treatment for neurodegenerative diseases in this category that has been shown to stop or reverse the condition.

Numerous research studies show potential for CBD as a treatment to help manage various symptoms of Alzheimer’s but none have been shown to cure or prevent the disease.

There is no standard dosage for CBD, so talk to your doctor about the best dose to manage your symptoms. Be sure to check the concentration of the product and follow the dosing recommendations.

CBD has been shown to be safe in daily doses up to 1,500mg. Side effects are infrequent and mild, generally limited to nausea, drowsiness, and changes in weight or appetite.

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. World Health Organization: WHO (2020). Dementia. Available from:
  2. Blessing, E.M., Steenkamp, M.M., Manzanares, J. and Marmar, C.R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics, 12(4), 825–836. Available from:
  3. ‌Gale, S.A., Acar, D. and Daffner, K.R. (2018). Dementia. The American Journal of Medicine, 131(10), 1161–1169. Available from:‌.
  4. Raz, L., Knoefel, J. and Bhaskar, K. (2015). The neuropathology and cerebrovascular mechanisms of dementia. Journal of Cerebral Blood Flow & Metabolism, 36(1), 172–186. Available from:
  5. Cerejeira, J., Lagarto, L. and Mukaetova-Ladinska, E.B. (2012). Behavioral and Psychological Symptoms of Dementia. Frontiers in Neurology. Available from:
  6. Anon, (2020). What is Alzheimer’s Disease? Available from:
  7. Bang, J., Spina, S. and Miller, B.L. (2015). Frontotemporal dementia. The Lancet, 386(10004), 1672–1682. Available from:‌.
  8. Iadecola, C. (2013). The Pathobiology of Vascular Dementia. Neuron, 80(4), 844–866. Available from:
  9. Roos, R.A. (2010). Huntington’s disease: a clinical review. Orphanet Journal of Rare Diseases, 5(1). Available from:‌.
  10. Gomperts, S.N. (2016). Lewy Body Dementias. CONTINUUM: Lifelong Learning in Neurology, 22(2, Dementia), 435–463. Available from:
  11. ‌Langa, K.M., Foster, N.L. and Larson, E.B. (2004). Mixed Dementia. JAMA, 292(23), p.2901. Available from:
  12. ‌VanDolah, H.J., Bauer, B.A. and Mauck, K.F. (2019). Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clinic Proceedings, 94(9), 1840–1851. Available from:
  13. ‌Sallaberry, C.A. and Astern, L. (2018). Journal of Young Investigators. Journal of Young Investigators, 34(6). Available from:‌.
  14. Krishnan, S., Cairns, R. and Howard, R. (2009). Cannabinoids for the treatment of dementia. Cochrane Database of Systematic Reviews. Available from:‌
  15. Pellati, F., Borgonetti, V., Brighenti, V., Biagi, M., Benvenuti, S. and Corsi, L. (2018). Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. BioMed Research International, pp.1–15. Available from:
  16. ‌Vallée, A., Lecarpentier, Y., Guillevin, R. and Vallée, J.-N. (2017). Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease. Available from:
  17. ‌Fernández-Ruiz, J., Sagredo, O., Pazos, M.R., García, C., Pertwee, R., Mechoulam, R. and Martínez-Orgado, J. (2013). Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Available from:‌.
  18. Ming, G. and Song, H. (2011). Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions. Neuron, 70(4), pp.687–702. Available from:
  19. ‌Esposito, G., Scuderi, C., Valenza, M., Togna, G.I., et al. (2011). Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement. PLoS ONE, 6(12), p.e28668. Available from:
  20. ‌Campos, A.C., Fogaça, M.V., Sonego, A.B. and Guimarães, F.S. (2016). Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacological Research, 112, 119–127. Available from:
  21. Ranganathan, M. and D’Souza, D.C. (2006). The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology, 188(4), 425–444. Available from:‌.
  22. Cheng, D., Spiro, A.S., Jenner, A.M., Garner, B. and Karl, T. (2014). Long-Term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Alzheimer’s Disease Transgenic Mice. Journal of Alzheimer’s Disease, 42(4), 1383–1396. Available from:
Kate Barrington, Health Expert

Kate Barrington holds a Bachelor’s degree in English and is the published author of several self-help books and nutrition guides. Also an avid dog lover and adoring owner of three cats, Kate’s love for animals has led her to a successful career as a freelance writer specializing in pet care and nutrition. Kate holds a certificate in fitness nutrition and enjoys writing about health and wellness trends — she also enjoys crafting original recipes. In addition to her work as a ghostwriter and author, Kate is also a blogger for a number of organic and natural food companies as well as a columnist for several pet magazines.

Slowly losing the ability to remember is not only heartbreaking it's horrifying. We have the top three best CBD oil for dementia selections in 2021 for you!